Results 61 to 70 of about 1,835 (174)
APP/Aβ Signaling Orchestrates Reactive Astrocyte Networks in Alzheimer's Disease
Journal of Neurochemistry, Volume 170, Issue 7, July 2026.Stress increases astrocyte APP production, generating amyloid‐β (Aβ). Aβ then diffuses to neighboring astrocytes, stimulating further APP and Aβ production and creating a self‐reinforcing cycle. Over time, impaired Aβ clearance leads to its accumulation, chronic inflammation, and contributes to sporadic Alzheimer's disease. ABSTRACT Alzheimer's disease
Gretsen Velezmoro Jauregui +16 more
wiley +1 more source
Two modes of enteric gliotransmission differentially affect gut physiology [PDF]
Glia, 2017 AbstractEnteric glia (EG) in the enteric nervous system can modulate neuronally regulated gut functions. Using molecular genetics, we assessed the effects that molecular entities expressed in EG and otherwise mediating two distinct mechanisms of gliotransmitter release, connexin 43 (Cx43) hemichannel vs. Ca2+‐dependent exocytosis, have on gut function.
Vladimir, Grubišić, Vladimir, Parpura
openaire +2 more sources
Frontiers in Cellular Neuroscience, 2018 Astrocytes from the hippocampus of chronic epileptic rats exhibit an abnormal pattern of intracellular calcium oscillations, characterized by an augmented frequency of long lasting spontaneous Ca2+ transients, which are sensitive to purinergic receptor ...
Mario Wellmann +8 more
doaj +1 more source
Archiv der Pharmazie, Volume 359, Issue 6, June 2026.Modulation of K2P and Kv7 channels has the potential to reduce hyperexcitability and hypersynchronicity within the thalamocortical system. This offers a new avenue to suppress spike and wave discharges, the electrophysiological hallmark of absence epilepsy.
Anushka Takhi +3 more
wiley +1 more source
Frontiers in Computational Neuroscience, 2012 The complexity of the signaling network that underlies astrocyte-synapse interactions may seem discouraging when tackled from a theoretical perspective.
Maurizio eDe Pitta' +10 more
doaj +1 more source
Journal of Neurochemistry, Volume 170, Issue 6, June 2026.Components and properties of Ca2+ buffers in astrocytes, which should be considered for data interpretation and in computational modeling of astrocyte Ca2+ activity. ABSTRACT Astrocytic Ca2+ signaling is essential for maintaining physiological brain function, including the modulation of synaptic transmission, neurovascular coupling, and ion homeostasis.
Kerstin Lenk +2 more
wiley +1 more source
GABA release by hippocampal astrocytes
Frontiers in Computational Neuroscience, 2012 Astrocytes can directly influence neuronal activity through the release of various transmitters acting on membrane receptors expressed by neurons. However, in contrast to glutamate and ATP for instance, the release of GABA by astrocytes is still poorly ...
Karim eLe Meur +4 more
doaj +1 more source
Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.• Excitatory neurons and astrocytes show marked alterations in the single‐cell spatial transcriptomic atlas of epileptogenic cortex from patients with focal cortical dysplasia type I (FCDI). • The CBLN2high excitatory neuron subtype may be associated with neuronal hyperexcitability and cortical development in FCDI.
Yaqian Zhang +9 more
wiley +1 more source
About astroglia in the brain and pathology
Анналы клинической и экспериментальной неврологии, 2017 More than 140 years astrocytes were described as passive cellularelements of the brain, and their function was limited participationin providing trophic potential of neurons.
S. A. Goryaynov +5 more
doaj +1 more source
Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.1. Astrocytes are central integrators of neural circuit function through tripartite synapse modulation and neurovascular coupling. 2. Dysregulation of glutamate/GABA homeostasis and neuroinflammation represents shared mechanisms across diverse neuropsychiatric disorders. 3.
Xinyu Liu +10 more
wiley +1 more source