Results 31 to 40 of about 77,800,290 (253)

Genistein ameliorates hyperuricemia-associated nephropathy in hyperuricemic mice

Food and Agricultural Immunology, 2021
Hyperuricemia is a metabolic disease caused by excessive production of uric acid (UA), which can cause gout, hypertension, hyperlipidemia and other diseases.
Bi Wei-Yun, Zhu Cailin
doaj   +1 more source

Sucrose- and H+-dependent charge movements associated with the gating of sucrose transporter ZmSUT1 [PDF]

, 2010
Background: In contrast to man the majority of higher plants use sucrose as mobile carbohydrate. Accordingly proton-driven sucrose transporters are crucial for cell-to-cell and long-distance distribution within the plant body.
Koepsell H., Hedrich, Rainer Franz, Hermann Koepsell, Carpaneto, A., Geiger D., Geiger, D., Geiger, Dietmar, Hedrich, Rainer, Hedrich, R., Hedrich R., Bamberg E., Ernst Bamberg, Carpaneto A., Carpaneto, Armando, Armando Carpaneto, Koepsell, Hermann, Bamberg, Ernst, Koepsell, H., Dietmar Geiger, Bamberg, E., Rainer Hedrich, Carpaneto A, Koepsell H, Bamberg E, Hedrich R, Geiger D   +25 more
core   +2 more sources

Effect of Aerobic Treadmill Exercise Regulating Glucose Transporter 9 on Renal Function in Hyperuricemia Rats

康复学报, 2022
ObjectiveTo explore the possible mechanism of aerobic treadmill exercise in improving renal function in hyperuricemia (HUA) rats.MethodsA total of 24 male SD rats were randomly divided into the Control group, the Model group and the Exercise group ...
LIANG Jiarong, YANG Huan, CUN Yongdan, WANG Lihuan, LI Yijie, YE Bin   +5 more
doaj  

Chemical Constituents from Roots of Sophora davidii (Franch.) Skeels and Their Glucose Transporter 4 Translocation Activities

Molecules, 2021
Sophora davidii (Franch.) Skeels is a multi-purpose traditional medicine that has long been used for the treatment of various diseases. To discover the potential bioactive composition of S. davidii, a chemical investigation was thus performed.
Kangdi Li, Yuanren Ma, Tongxi Zhou, Xinzhou Yang, Ho-Young Choi   +4 more
doaj   +1 more source

Anti-Inflammatory and Anti-Hyperuricemic Effects of Chrysin on a High Fructose Corn Syrup-Induced Hyperuricemia Rat Model via the Amelioration of Urate Transporters and Inhibition of NLRP3 Inflammasome Signaling Pathway

Antioxidants, 2021
Hyperuricemia is the main cause of gout and involved in the occurrence of many other diseases such as hyperlipidemia and hypertension correlated with metabolic disorders.
Yi-Hsien Chang, Yi-Fen Chiang, Hsin-Yuan Chen, Yun-Ju Huang, Kai-Lee Wang, Yong-Han Hong, Mohamed Ali, Tzong-Ming Shieh, Shih-Min Hsia   +8 more
doaj   +1 more source

Oral metformin transiently lowers post-prandial glucose response by reducing the apical expression of sodium-glucose co-transporter 1 in enterocytes

, 2023
Summary: Metformin (MET) is the most prescribed antidiabetic drug, but its mechanisms of action remain elusive. Recent data point to the gut as MET’s primary target. Here, we explored the effect of MET on the gut glucose transport machinery.
Thevenet, Julien, Auger, F., Marciniak, Camille, Lestavel, Sophie, Mühlemann, Markus, Vantyghem, M.C., Bonner, Caroline, Markus Mühlemann, Caroline Bonner, Bart Staels, Kerr-Conte, J., François Pattou, Kerr-Conte, Julie, Auger, Florent, Thomas Hubert, Thorens, Bernard, Benoit Deprez, Mehdi Daoudi, Delzenne, Nathalie M., Hermann Koepsell, Vantyghem, Marie, C, Damien Huglo, Julie Kerr-Conte, Daniela Zdzieblo, Briand, Olivier, Laure B. Bindels, Daoudi, Mehdi, Daoudi, M., Delzenne, N.D., Hubert, T., Koepsell, H., Peschard, S., Laferrère, B., Pattou, F., Simon Peschard, Quenon, Audrey, Thevenet, J., Briand, O., Lorea Zubiaga, Gianni Pasquetti, Pattou, François, Marciniak, C., Zdzieblo, Daniela, Deprez, Benoit, Deprez, B., Raverdy, V., Laferrère, Blandine, Vantyghem, Marie C, Delzenne, Nathalie, D, Lestavel, S., Bindels, Laure B., Bernard Thorens, Bindels, Laure, B, Quenon, A., Touche, Veronique, Audrey Quenon, Mühlemann, M., Blandine Laferrère, Marie C. Vantyghem, Zubiaga, L., Touche, V., Staels, B., Pasquetti, G., Bonner, C., Zdzieblo, D., Raverdy, Violeta, Camille Marciniak, Veronique Touche, Peschard, Simon, Olivier Briand, Staels, Bart, Bindels, L.B., Pasquetti, Gianni, Koepsell, Hermann, Thorens, B., Nathalie D. Delzenne, Zubiaga, Lorea, Huglo, Damien, Julien Thevenet, Sophie Lestavel, Violeta Raverdy, Huglo, D., Florent Auger, Hubert, Thomas   +83 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Isomer-specific regulation of metabolism and PPARγ signaling by CLA in human preadipocytes

Journal of Lipid Research, 2003
Trans-10,cis-12 conjugated linoleic acid (CLA) has previously been shown to be the CLA isomer responsible for CLA-induced reductions in body fat in animal models, and we have shown that this isomer, but not the cis-9,trans-11 CLA isomer, specifically ...
J.Mark Brown, Maria Sandberg Boysen, Søren Skov Jensen, Ron F. Morrison, Jayne Storkson, Renee Lea-Currie, Michael Pariza, Susanne Mandrup, Michael K. McIntosh   +8 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Diversity, expression, and structural modeling of sugar transporters in Anisakis simplex s. s. L3 and L4 larvae: an in vitro and in silico study

Frontiers in Cellular and Infection Microbiology
IntroductionGlucose transporter (GLUT) research in parasitic nematodes focuses on identifying and characterizing developmentally regulated isoforms, elucidating their regulatory and structural properties, and evaluating their potential as drug targets ...
Iwona Polak, Robert Stryiński, Łukasz Paukszto, Jan Paweł Jastrzębski, Iwona Bogacka, Elżbieta Łopieńska-Biernat   +5 more
doaj   +1 more source