Results 111 to 120 of about 38,797 (256)

Estudo do efeito e do mecanismo de ação das sulfonamidas e acilhidrazonas sintéticas na homeostasia da glicose [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2014.Durante as últimas décadas, observou-se um aumento surpreendente na prevalência do diabetes melito (DM)
Frederico, Marisa Jádna Silva
core  

The Acute Effects of Interrupting Prolonged Sitting With Regular Activity Breaks on Postprandial Glucose and Insulin in Adults: A Systematic Review and Meta‐Analysis

Obesity Reviews, EarlyView.
ABSTRACT Background Regular activity breaks improve postprandial glycemia, but the effects across different population groups and modes of breaks remain unclear. This systematic review and meta‐analysis examined the impact of activity breaks on postprandial glucose and insulin response in adult populations.
Jennifer T. Gale, Hannah Martin, Jillian J. Haszard, Meredith C. Peddie   +3 more
wiley   +1 more source

Brain GLUT3 and GLUT4 levels.

, 2013
The levels of total GLUT3 and GLUT4 in whole brain from nonTg and 3xTg-AD mice +/- lipoic acid (young and old) were determined by western-blot analyses. Left panels (A, B, and C) correspond to data from young mice; right panels (D, E, and F) to data from
Fei Yin (179978), Enrique Cadenas (92522), Roberta D. Brinton (180782), Garnik Akopian (434302), Harsh Sancheti (434301), John P. Walsh (280331)   +5 more
core   +1 more source

Building GLUT4 vesilces: CHC22 clathrin's human touch [PDF]

, 2020
Insulin stimulates glucose transport by triggering regulated delivery of intracellular vesicles containing the GLUT4 glucose transporter to the plasma membrane. This process is defective in diseases such as type 2 diabetes (T2DM). While studies in rodent
Bryant, NJ, Brodsky, F, Gould, GW
core  

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Insulin stimulates fusion, but not tethering, of GLUT4 vesicles in skeletal muscle of HA-GLUT4-GFP transgenic mice

, 2012
Insulin stimulates fusion, but not tethering, of GLUT4 vesicles in skeletal muscle of HA-GLUT4-GFP transgenic mice. Am J Physiol Endocrinol Metab 302: E950-E960, 2012.
Chadt, Alexandra, Cushman, Samuel W., Al-Hasani, Hadi, Yver, Dena R., Stenkula, Karin, Lund University., Lisinski, Ivonne, Zimmerberg, Joshua, Lizunov, Vladimir A., Stenkula, Karin,, Gavrilova, Oksana   +10 more
core   +1 more source

Redox‐regulated signalling of adaptations to contractile activity in skeletal muscle: Implications for age‐related muscle weakness

Experimental Physiology, EarlyView.
Abstract Skeletal muscle adaptation to contractile activity is modulated by redox signalling, primarily through reactive oxygen species (ROS) such as hydrogen peroxide (H2O2). Early research framed ROS as deleterious byproducts of exercise, but subsequent studies have established their roles as signalling molecules involved in mitochondrial biogenesis,
Malcolm J. Jackson
wiley   +1 more source

In vitro muscle contraction: A technical review on electrical pulse stimulation in C2C12 cells

Experimental Physiology, EarlyView.
Abstract Electrical pulse stimulation (EPS) of skeletal muscle cells is increasingly used to model exercise In vitro. The murine C2C12 myotube system has become a common platform for such studies, yet wide variability in EPS protocols hampers reproducibility and cross‐study comparisons.
Mark R. C. van de Meene, Anita M. van den Hoek, Roeland Hanemaaijer, Lars Verschuren, Jelle C. B. C. de Jong   +4 more
wiley   +1 more source

Chloroquine Increases Glucose Uptake via Enhancing GLUT4 Translocation and Fusion with the Plasma Membrane in L6 Cells

Cellular Physiology and Biochemistry, 2016
Background/Aims: Chloroquine can induce an increase in the cellular uptake of glucose; however, the underlying mechanism is unclear. Methods: In this study, translocation of GLUT4 and intracellular Ca2+ changes were simultaneously observed by confocal ...
Qi Zhou, Xinzhou Yang, Mingrui Xiong, Xiaolan Xu, Li Zhen, Weiwei Chen, Yan Wang, Jinhua Shen, Ping Zhao, Qing-Hua Liu   +9 more
doaj   +1 more source

The effects of bed rest on cardiometabolic health: A systematic review and meta‐analysis

Experimental Physiology, EarlyView.
Abstract Horizontal bed rest (HBR) and head‐down tilt (HDT) are models of physical inactivity. In this systematic review and meta‐analysis, we aimed to quantify changes in cardiometabolic outcomes during HBR and HDT in healthy adults. Following the PRISMA guidelines, we searched PubMed, Scopus, Web of Science and Cochrane Library until 1 October 2025 ...
Konstantinos Prokopidis, Tyler Daubrah‐Scott, Alyssa Varanoske, Jordi Morwani‐Mangnani, David D. Church, Colleen S. Deane, Bethan E. Phillips, Emily J. Arentson‐Lantz   +7 more
wiley   +1 more source