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Glutamate-Mediated Excitotoxicity and Neurodegeneration in Alzheimer’s Disease
Neurochemistry International, 2004Alzheimer's disease (AD) is the most common form of dementia, accounting for 60-70% of cases in subjects over 65 years of age. Several postulates have been put forward that relate AD neuropathology to intellectual and functional impairment. These range from free-radical-induced damage, through cholinergic dysfunction, to beta-amyloid-induced toxicity ...
Peter R Dodd
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Glutamate-Mediated Excitotoxicity
1999Excitotoxicity — the ability of glutamate receptor activation to trigger neuronal cell death — has been recognized for more than four decades (Lucas and New-house 1957; Olney 1969; Choi 1988b). Over the last 10–15 years, there has been an accumulation of evidence that suggests that glutamate toxicity contributes to brain or spinal cord tissue damage in
G. A. Kerchner, A. H. Kim, D. W. Choi
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Glutamate excitotoxicity in a model of multiple sclerosis
Nature Medicine, 2000Glutamate excitotoxicity mediated by the AMPA/kainate type of glutamate receptors damages not only neurons but also the myelin-producing cell of the central nervous system, the oligodendrocyte. In multiple sclerosis, myelin, oligodendrocytes and some axons are lost as a result of an inflammatory attack on the central nervous system.
D, Pitt, P, Werner, C S, Raine
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European Journal of Neuroscience, 2019
AbstractTraumatic brain injury (TBI) is a leading major cause of morbidity and mortality in youth and individuals under 45 year age. A wide variety of cellular and molecular mechanisms have been identified contributing to the pathogenesis of TBI.
Joel Tehse, Changiz Taghibiglou
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AbstractTraumatic brain injury (TBI) is a leading major cause of morbidity and mortality in youth and individuals under 45 year age. A wide variety of cellular and molecular mechanisms have been identified contributing to the pathogenesis of TBI.
Joel Tehse, Changiz Taghibiglou
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Blockade of glutamate excitotoxicity and its clinical applications
Neurochemical Research, 1993Glutamate has long been known to play a vital role in the normal functioning of neurons, serving as the main excitatory neurotransmitter in the central nervous system. The normal function of glutamate, as a means of communication from one neuron to the next, breaks down in certain disease states.
K, Hirose, P H, Chan
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Glutamate Excitotoxicity in Multiple Sclerosis
2004Multiple sclerosis (MS) is a disease of central white matter with prominent demyelination and oligodendrocyte loss. Recent data on MS pathogenesis has implicated disruption of glutamate homeostasis as a disease mechanism, at the center of which, molecules of the glutamate clearance pathway are selectively downregulated on oligodendrocytes.
David Pitt, Cedric S. Raine
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Excitotoxic effects of glutamate on cochlear organotypic cultures
Journal of Huazhong University of Science and Technology [Medical Sciences], 2015Glutamate (Glu) is the major afferent excitatory neurotransmitter in the auditory system, and excessive Glu may play an important role in cochlear dysfunction. It is unclear how excessive Glu plays roles in cochlear dysfunction in cochlear organotypic cultures.
Yao, Hu +4 more
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Intracellular Signalling in Glutamate Excitotoxicity
1996The excitatory neurotransmitter glutamate is a potent and effective neurotoxin. When applied in vitro, a. brief exposure to a moderate concentration of glutamate is sufficient to kill neurons.1,2 In vivo, glutamate-induced neuronal injury probably contributes to damage that results from cerebrovascular accidents and trauma.2–4 A number of important ...
Ian J. Reynolds +3 more
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Dearth of glutamate transporters contributes to striatal excitotoxicity
Experimental Neurology, 2004Since excitotoxicity is hypothesized to contribute to cell death in Huntington's disease (HD), we examined the susceptibility of striatal and hippocampal neurons to glutamate-induced cell death. Striatal cultures were more susceptible to glutamate-triggered toxicity than sister hippocampal cultures.
Tatiana, Brustovetsky +4 more
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Glutamate Excitotoxicity Linked to Spermine Oxidase Overexpression
Molecular Neurobiology, 2018Excitotoxic stress has been associated with several different neurological disorders, and it is one of the main causes of neuronal degeneration and death. To identify new potential proteins that could represent key factors in excitotoxic stress and to study the relationship between polyamine catabolism and excitotoxic damage, a novel transgenic mouse ...
Pietropaoli S +11 more
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