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Dendritic and Mitochondrial Changes During Glutamate Excitotoxicity
Neuropharmacology, 2007Glutamate is the predominant excitatory neurotransmitter in the mammalian central nervous system (CNS) and is normally stored intracellularly. However, in instances of CNS injury or disease, increased concentrations of extracellular glutamate can result in the over-activation of ionotropic glutamate receptors and trigger neuronal cell death (termed ...
Greenwood, Sam M. +1 more
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Role of astrocytes in glutamate homeostasis: Implications for excitotoxicity
Neurotoxicity Research, 2005Glutamate homeostasis in the brain is maintained by its well balanced release, uptake and metabolism. It appears that astrocytes play a prominent role in this context since they possess a very powerful battery of glutamate transporters. Thus, malfunction of astrocytic glutamate transporters will lead to an excessively high extracellular glutamate ...
Arne, Schousboe, Helle S, Waagepetersen
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ISCHEMIC STROKE INDUCTION BY GLUTAMATE EXCITOTOXICITY
Proceedings of the West Virginia Academy of Science, 2019One of the leading causes of epilepsy is cerebral ischemia, also known as ischemic stroke. The brain is particularly vulnerable to ischemia due to the high rate of oxidative metabolism, which requires a continuous supply of oxygen and glucose. By initiating an excitotoxic glutamate injury, it is hypothesized to induce ischemic epileptic discharges in ...
Cristal Anthony, Charles B Anthony
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Glutamate receptors and excitotoxicity.
Research publications - Association for Research in Nervous and Mental Disease, 1993The features of central glutamate synapses are well suited to the spectrum of functions these elements serve in brain function. However, receptor-mediated mechanisms are only one facet of phenomena such as excitotoxicity or long-term potentiation, which almost certainly involve other neuronal components, e.g., other transmitter systems, voltage-gated ...
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Excitotoxins, Glutamate Receptors, and Excitotoxicity
1994The increasing awareness in the various fields of the neurosciences of the dual role of glutamate (Glu) as a neurotransmitter and toxin justifies the inclusion of a chapter on excitotoxins and Glu receptors in a book devoted to neurotoxins. Recent reviews dealing with the topic are available particularly with regard to the involvement of Glu and Glu ...
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Neurochemistry International
This study aimed to investigate whether lupeol, a pentacyclic triterpenoid, affects glutamate release in isolated nerve terminals (synaptosomes) from the rat cerebral cortex and whether lupeol affects the excitotoxicity induced by kainic acid (KA) in rats.
Cheng-Wei Lu +6 more
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This study aimed to investigate whether lupeol, a pentacyclic triterpenoid, affects glutamate release in isolated nerve terminals (synaptosomes) from the rat cerebral cortex and whether lupeol affects the excitotoxicity induced by kainic acid (KA) in rats.
Cheng-Wei Lu +6 more
openaire +2 more sources
MFN2 Couples Glutamate Excitotoxicity and Mitochondrial Dysfunction in Motor Neurons *♦
Journal of Biological Chemistry, 2015Xinglong Wang +2 more
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