High ALG1 Expression Is Correlated With Poor Prognosis and the Immune Microenvironment in Glioma
Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.ABSTRACT Glioma is the most prevalent primary tumour in the central nervous system. This study investigates ALG1 expression in glioma and its clinical significance. Using the TCGA and CGGA databases, a bioinformatics analysis examines ALG1 expression, its prognostic value, and its link to the immune microenvironment. Clinical samples are analysed using
Shuxiang Li +10 more
wiley +1 more source
Analyzing peptides and proteins by mass spectrometry: principles and applications in proteomics [PDF]
, 2012 Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32166The study of proteins has been a key element in biomedicine and biotechnology because of their important role in cell functions or enzymatic activity. Cells are the basic unit of living
Estanyol i Ullate, Josep Maria +3 more
core +1 more source
PDMSA: A Web‐Based Tool for Pan‐Cancer Survival Analysis Using DNA Methylation Levels as Biomarkers
Advanced Genetics, Volume 7, Issue 1, March 2026.PDMSA is a web‐based tool for exploring DNA methylation biomarkers across 39 cancer types. It integrates data from 8369 samples and performs survival analysis via Kaplan–Meier and Cox regression. With PDMSA, users can assess the impact of methylation on tumor survival outcomes, aiding the investigation of tumor development mechanisms.
Weiwei Guo +5 more
wiley +1 more source
Label-free quantitative comparison of cerebrospinal fluid glycoproteins and endogenous peptides in subjects with Alzheimer's disease, mild cognitive impairment, and healthy individuals [PDF]
, 2016 PURPOSE: The goal of this study is to investigate putative molecular dynamic changes in cerebrospinal fluids (CSFs) collected from individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD) as compared to healthy controls ...
Asthana, S +6 more
core +1 more source
Magnesium Deficiency Accelerates Gut Aging and Increases Susceptibility to Colitis
Aging Cell, Volume 25, Issue 3, March 2026.Aging is associated with a gut‐specific decline in magnesium (Mg), which accelerates intestinal aging and aggravates colitis in aged mice. Mechanistically, Mg deficiency reshapes the phosphoproteome and N‐glycoproteome, destabilizing adhesion complexes.
Rou Zhang +16 more
wiley +1 more source
Deciphering the functions of O-GlcNAc glycosylation in the brain: The role of site-specific quantitative O-GlcNAcomics [PDF]
, 2018 The dynamic posttranslational modification O-linked β-N-acetylglucosamine glycosylation (O-GlcNAcylation) is present on thousands of intracellular proteins in the brain.
Hsieh-Wilson, Linda C. +2 more
core
The GalNAc-type O-Glycoproteome of CHO Cells Characterized by the SimpleCell Strategy [PDF]
, 2014 The Chinese hamster ovary cell (CHO) is the major host cell factory for recombinant production of biological therapeutics primarily because of its “human-like” glycosylation features.
Alder Schulz, Morten +12 more
core +1 more source
eLife, 2020 UDP-glucose:glycoprotein glucosyltransferase (UGGT) 1 and 2 are central hubs in the chaperone network of the endoplasmic reticulum (ER), acting as gatekeepers to the early secretory pathway, yet little is known about their cellular clients.
Benjamin M Adams +4 more
doaj +1 more source