Results 91 to 100 of about 4,132 (206)

The Critical Role of GALNTs‐Regulated O‐GalNAc Glycosylation in Cancer Malignancy

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
The GALNT family initiates mucin‐type O‐GalNAc glycosylation in the Golgi apparatus and how regulatory mechanisms, including GALNT relocalization and microRNA control, modulate this process. Dysregulated O‐GalNAc glycosylation alters key cellular behaviors and promotes cancer malignancy, highlighting its relevance to tumor progression as well as its ...
Jiahao Liu, Sihan Wu, Ge Zhang, Jiehan Li, Yuhan Yin, Aman Uiiah, Sanfei Peng, Yang Fu   +7 more
wiley   +1 more source

Bioinformatics in Glycoproteomics – Challenges, Frontiers and Solutions

, 2011
The development of suitable bioinformatic tools has been a crucial step towards the success of proteomics workflows in the last decade. Software and workflows that allow for automated and reliable identification of proteins from complex mixtures have ...
Kolarich, D., Rapp, E., Packer, N.
core   +1 more source

Inhaled Angiopoietin‐Like 4 Antisense Oligonucleotide Therapy for Lung Injury and Fibrosis

Advanced Science, Volume 13, Issue 23, 23 April 2026.
Inhaled antisense oligonucleotides targeting ANGPTL4 attenuate inflammation, preserve barrier integrity, and reduce fibrosis in both infectious and sterile lung injury models. Integrated transcriptomic analysis reveals a conserved ANGPTL4‐regulated gene network coordinating hypoxic, inflammatory, apoptotic, and stress‐response pathways.
Haiyang Fan, Yuanyang Tan, Junhang Zhang, Xiaoya Liu, Jing Qu, Damien Chua, Hong Sheng Cheng, Joseph Han Sol Kim, Yu Xuan Liu, Changfei Qin, Yingzi Liu, Dezhi Li, Jikang Qiu, Mengshi Chi, Mingmin Bi, Qiwei Zhang, Yun Li, Masoumeh Motamedi Joibari, Stefan K Nilsson, Nguan Soon Tan, Yunping Fan, Liang Li   +21 more
wiley   +1 more source

Comparison of Three Glycoproteomic Methods for the Analysis of the Secretome of CHO Cells Treated with 1,3,4-O-Bu₃ManNAc

Bioengineering, 2020
Comprehensive analysis of the glycoproteome is critical due to the importance of glycosylation to many aspects of protein function. The tremendous complexity of this post-translational modification, however, makes it difficult to adequately characterize ...
Joseph L. Mertz, Shisheng Sun, Bojiao Yin, Yingwei Hu, Rahul Bhattacharya, Michael J. Bettenbaugh, Kevin J. Yarema, Hui Zhang   +7 more
doaj   +1 more source

B4GALNT4‐Mediated Glycosylation of PDK1 Activates the PI3K‐AKT Signaling Pathway to Promote Prostate Cancer Progression

Advanced Science, Volume 13, Issue 23, 23 April 2026.
This study identifies B4GALNT4 as a key driver of prostate cancer (PCa). It shows that B4GALNT4 glycosylates PDK1 protein at the N531 site, which stabilizes the PDK1 and constitutively activates the PI3K‐AKT pathway. This mechanism promotes tumor cell proliferation, migration, and invasion. The findings establish the B4GALNT4‐PDK1 glycosylation axis as
Shaoqin Jiang, Mengqiang Li, Qingfu Su, Ruiling Dou, Shaoshan Lin, Jili Zhang, Xiaochen Sun, Haolan Yu, Wei Bao, Min Qu, Yan Wang, Chenghua Yang, Xu Gao   +12 more
wiley   +1 more source

Glycoproteomics [PDF]

Nature Methods, 2011
Nachimuthu Saraswathy, Ponnusamy Ramalingam   +1 more
  +4 more sources

Toward Automated N‑Glycopeptide Identification in Glycoproteomics

, 2016
Advances in software-driven glycopeptide identification have facilitated N-glycoproteomics studies reporting thousands of intact N-glycopeptides, i.e., N-glycan-conjugated peptides, but the automated identification process remains to be scrutinized ...
Nicolle H. Packer (802996), Benjamin L. Parker (1874899), Edward S. X. Moh (3097038), Morten Thaysen-Andersen (1725427), Marshall Bern (802724), Ling Y. Lee (1342515)   +5 more
core   +2 more sources

Additional file 2 of Investigation of cell wall proteins of C. sinensis leaves by combining cell wall proteomics and N-glycoproteomics

, 2021
Additional file 2: Table S2. N-glycoproteins identified from C.
Ziming Gong (11308591), Linlong Ma (5328389), Jing Fan (149601), Hongju Hu (785455), Dan Cao (317933), Xiaofang Jin (11308594), Yanli Liu (198140)   +6 more
core   +1 more source

Quantitative Proteome-wide O-Glycoproteomics Analysis with FragPipe

<p>Processed search results and parameter files supporting the analyses presented in the publication "Quantitative Proteome-wide O-Glycoproteomics Analysis with FragPipe".</p ...
Polasky, Daniel
core   +2 more sources

Maturing glycoproteomics technologies provide unique structural insights into the N-glycoproteome and its regulation in health and disease

, 2016
The glycoproteome remains severely understudied because of significant analytical challenges associated with glycoproteomics, the system-wide analysis of intact glycopeptides. This review introduces important structural aspects of protein N-glycosylation
Packer, Nicolle H., Thaysen-Andersen, Morten, Schulz, Benjamin L.   +2 more
core   +1 more source