Results 91 to 100 of about 36,633 (265)

Proteomic profile of CSF obtained at the time of diagnosis determines amyotrophic lateral sclerosis progression and survival: CXCL7 levels in disease prognosis and survival

Brain Pathology, EarlyView.
Untargeted multiomic profiling of cerebrospinal fluid reveals that proteomic, but not lipidomic, signatures robustly distinguish ALS patients from controls and stratify individuals by survival, highlighting marked molecular differences between short survival and long survival disease.
Sergio Roca‐Pereira, Yaiza López‐Sampere, Pol Mengod‐Soler, Mario Peña‐Fonteboa, Carla Marco, Alejandro Caravaca‐Puchades, Raúl Domínguez, Juan Francisco Vázquez‐Costa, Enrique Santamaría, Joaquín Fernández‐Irigoyen, María J. Colomina, Isabel León Moreno, Antonio Martínez Yélamos, Sergio Martínez Yélamos, Gabriel Santpere, Elia Obis, Manuel Portero‐Otín, Gerard Piñol‐Ripoll, Mónica Povedano, Pol Andrés‐Benito   +19 more
wiley   +1 more source

Biological Roles of Aberrantly Expressed Glycosphingolipids and Related Enzymes in Human Cancer Development and Progression

Frontiers in Physiology, 2018
Glycosphingolipids (GSLs), which consist of a hydrophobic ceramide backbone and a hydrophilic carbohydrate residue, are an important type of glycolipid expressed in surface membranes of all animal cells. GSLs play essential roles in maintenance of plasma
Dinghao Zhuo, Xiang Li, Feng Guan
doaj   +1 more source

Glucosylsphingosine Is a Highly Sensitive and Specific Biomarker for Primary Diagnostic and Follow-Up Monitoring in Gaucher Disease in a Non-Jewish, Caucasian Cohort of Gaucher Disease Patients [PDF]

, 2013
Gaucher disease (GD) is the most common lysosomal storage disorder (LSD). Based on a deficient β-glucocerebrosidase it leads to an accumulation of glucosylceramide. Standard diagnostic procedures include measurement of enzyme activity, genetic testing as
A Zimran, AC Vedder, Ales Dudesek, Andrea Dardis, Anja Röhle, Anne-Katrin Giese, Ari Zimran, Arndt Rolfs, B Rosengren, C Auray-Blais, CE Hollak, CE Hollak, CE Metz, Daniel Mascher, Deborah Elstein, E Lloyd-Evans, E Schutyser, E Schutyser, ER Delong, GM Pastores, Hermann Mascher, I Kurt, I Maire, J Wittmann, Jan Lukas, JE Groener, JE Groener, JM Aerts, K Nakamura, KL Chang, L van Dussen, Matthias Wittstock, MH Zweig, N Dekker, O Nilsson, OA Bodamer, PJ Orchard, PJ Seeman, Rayk Hübner, RG Boot, RY Wang, S Atsumi, S Aviner, S Struyf, T Taketomi, Tobias Böttcher, U Finckh, Ulrike Grittner, Uta Gölnitz, Wolfgang Meyer, XY Mao, Y Sun   +51 more
core   +3 more sources

Comprehensive Genome Analysis on the Novel Species Sphingomonas panacis DCY99(T) Reveals Insights into Iron Tolerance of Ginseng [PDF]

, 2020
Plant growth-promoting rhizobacteria play vital roles not only in plant growth, but also in reducing biotic/abiotic stress. Sphingomonas panacis DCY99(T) is isolated from soil and root of Panax ginseng with rusty root disease, characterized by raised ...
Balusamy, Sri Renukadevi, Huo, Yue, Kim, Donghyuk, Kim, Yeon-Ju, Le, Hoa Thi, Nong, Linh Khanh, Park, Joon Young, Yang, Deok Chun   +7 more
core   +1 more source

Untargeted Metabolomic and Lipidomic Profiles of Gingival Crevicular Fluid in the Context of Periodontitis

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim(s) This cross‐sectional clinical study aimed to explore the untargeted metabolomic and lipidomic profiles in gingival crevicular fluid (GCF) obtained from healthy individuals and patients with periodontitis. Materials and Methods GCF was collected from 17 periodontally healthy and 19 periodontitis patients.
Caroline H. Henderzahs, Chiaki Yamada, Alexandr Morozov, Thelmalane Yalartai, Vanchit John, Hawra AlQallaf, Alexandru Movila   +6 more
wiley   +1 more source

Glycosphingolipids and drug resistance

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2006
Drug resistance, an all too frequent characteristic of cancer, represents a serious barrier to successful treatment. Although many resistance mechanisms have been described, those that involve membrane-resident proteins belonging to the ABC (ATP binding cassette) transporter superfamily are of particular interest.
Gouaze-Andersson, Valerie, Cabot, Myles C.   +1 more
openaire   +2 more sources

Transcriptional Regulation of T-Cell Lipid Metabolism: Implications for Plasma Membrane Lipid Rafts and T-Cell Function

Frontiers in Immunology, 2017
It is well established that cholesterol and glycosphingolipids are enriched in the plasma membrane (PM) and form signaling platforms called lipid rafts, essential for T-cell activation and function.
George A. Robinson, Kirsty E. Waddington, Kirsty E. Waddington, Ines Pineda-Torra, Elizabeth C. Jury   +4 more
doaj   +1 more source

Porcine iGb3s gene silencing provides minimal benefit for clinical xenotransplantation [PDF]

, 2016
Background The Galα(1,3)Gal epitope (α-GAL), created by α-1,3-glycosyltransferase-1 (GGTA1), is a major xenoantigen causing hyperacute rejection in pig-to-primate and pig-to-human xenotransplantation.
Butler, James R., Estrada, Jose L., Ladowski, Joseph M., Li, Ping, Martens, Gregory R., Platt, Frances, Priestman, David, Skill, Nicholas J., Tector, A. Joseph, Tector, Matthew   +9 more
core   +1 more source

WRKY27‐RAP2.7 Regulatory Module Promotes Cold Tolerance via Modulation of Lignin Biosynthesis and Redox Homeostasis by Regulating Cinnamyl Alcohol Dehydrogenase 7 and Glutathione S‐Transferase F6

Plant Biotechnology Journal, EarlyView.
ABSTRACT Cold stress adversely affects plant growth and development, significantly limiting fruit yield and quality in citrus. Ichang papeda (Citrus ichangensis), a cold‐tolerant citrus species, serves as a valuable genetic resource for studying cold adaptation, yet the key genes and their modes of action underlying the cold stress response remain ...
Jing Qu, Peng Xiao, Yilei Wang, Tian Fang, Haowei Chen, Chunlong Li, Ji‐Hong Liu   +6 more
wiley   +1 more source

The Enigmatic Role of GBA2 in Controlling Locomotor Function

Frontiers in Molecular Neuroscience, 2017
The non-lysosomal glucosylceramidase GBA2 catalyzes the hydrolysis of glucosylceramide to glucose and ceramide. Loss of GBA2 function results in accumulation of glucosylceramide.
Marina A. Woeste, Dagmar Wachten, Dagmar Wachten   +2 more
doaj   +1 more source