Results 81 to 90 of about 25,840 (267)

A pore-forming β-trefoil lectin with specificity for the tumor-related glycosphingolipid Gb3 [PDF]

, 2022
Simona Notová, François Bonnardel, Francesca Rosato, Lina Šiukštaitė, Jessica Schwaiger, Nicolai V. Bovin, Annabelle Varrot, Winfried Römer, Frédérique Lisacek, Anne Imberty   +9 more
openalex   +1 more source

Preclinical efficacy and safety of adeno-associated virus 5 alpha-galactosidase: A gene therapy for Fabry disease

Molecular Therapy: Methods & Clinical Development
We developed a novel adeno-associated virus 5 gene therapy (AAV5-GLA) expressing human alpha-galactosidase A (GLA) under the control of a novel, small and strong, liver-restricted promoter.
Jolanda M.P. Liefhebber, Giso Brasser, Elisabeth A. Spronck, Roelof Ottenhoff, Lieke Paerels, Maria J. Ferraz, Lukas K. Schwarz, Nikoleta Efthymiopoulou, Chi-Lin Kuo, Paula S. Montenegro-Miranda, Melvin M. Evers, Johannes M.F.G. Aerts, Ying Poi Liu   +12 more
doaj   +1 more source

Inhibition of Hypersialylation in Human Intervertebral Disc Degeneration Modulates Inflammation and Metabolism

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Glycosylation, specifically hypersialylation, is identified as a critical factor in human intervertebral disc (IVD) degeneration—a major cause of low back pain. This study demonstrates that inhibiting sialylation reduces inflammation and oxidative stress in IVD tissues, suggesting new therapeutic possibilities.
Kieran Joyce, Aert F. Scheper, Aung Myat Phyo, Roisin O’ Flaherty, Richard Drake, Aiden Devitt, Martina Marchetti‐Deschmann, Radka Saldova, Abhay Pandit   +8 more
wiley   +1 more source

Lysosomal storage diseases and the heat shock response: convergences and therapeutic opportunities

Journal of Lipid Research, 2014
Lysosomes play a vital role in the maintenance of cellular homeostasis through the recycling of cell constituents, a key metabolic function which is highly dependent on the correct function of the lysosomal hydrolases and membrane proteins, as well as ...
Linda Ingemann, Thomas Kirkegaard
doaj   +1 more source

Intestinal Neutral Ceramidase Deficiency Triggers Regulatory T Cell Response via Gd3 to Protect the Host from Intestinal Inflammation

Advanced Science, Volume 13, Issue 5, 27 January 2026.
Deletion of ASAH2 in intestinal epithelial cells induces the accumulation of ganglioside GD3 via regulating ST8SIA1. GD3 is identified as the glycolipid ligand for the inhibitory receptor Siglec‐E on macrophages. GD3/Siglec‐E ligation polarizes macrophages and promotes the proliferation of colonic ST2+ T regulatory cells via the induction of IL‐33. The
Zhishan Xu, Chao Lei, Mukesh K Sriwastva, Ting Wang, Amanguli Tuohongerbieke, Xiaotong Song, Collin Noud, Shannon Derkson, Yi Tan, Gerald Dryden, Craig J McClain, Zhongbin Deng   +11 more
wiley   +1 more source

Myriocin slows the progression of established atherosclerotic lesions in apolipoprotein E gene knockout mices⃞

Journal of Lipid Research, 2008
The serine palmitoyl transferase inhibitor myriocin potently suppresses the development of atherosclerosis in apolipoprotein E (apoE) gene knockout (apoE−/−) mice fed a high-fat diet.
Elias N. Glaros, Woojin S. Kim, Carmel M. Quinn, Wendy Jessup, Kerry-Anne Rye, Brett Garner   +5 more
doaj   +1 more source

GSK3β‐Regulated Lipolysis is Required for Histone Acetylation and Decidualization in Early Pregnancy

Advanced Science, Volume 13, Issue 5, 27 January 2026.
Uterine Gsk3b knockout impairs decidual cell terminal differentiation by causing lipid droplet accumulation. GSK3β phosphorylates RNF213 to promote its lysosomal degradation, thereby enhancing lipolysis. The released fatty acids undergo β‐oxidation to generate acetyl‐CoA, which modulates histone acetylation and regulates decidual cell terminal ...
Peiran Wang, Yedong Tang, Xueling Zhao, Yu Ni, Hualan Zhou, Enhao Zhang, Gaizhen Li, Han Cai, Yinan Wang, James R. Woodgett, Wenbo Deng, Haibin Wang, Zhongxian Lu, Haili Bao, Shuangbo Kong   +14 more
wiley   +1 more source

Investigations on Aberrant Glycosylation of Glycosphingolipids in Colorectal Cancer Tissues Using Liquid Chromatography and Matrix-Assisted Laser Desorption Time-of-Flight Mass Spectrometry (MALDI-TOF-MS)

Molecular & Cellular Proteomics, 2013
Cancer is a leading cause of death and alterations of glycosylation are characteristic features of malignant cells. Colorectal cancer is one of the most common cancers and its exact causes and biology are not yet well understood.
S. Holst, K. Stavenhagen, C. Balog, C. Koeleman, Liam M. McDonnell, O. Mayboroda, A. Verhoeven, W. Mesker, R. Tollenaar, A. Deelder, M. Wuhrer   +10 more
semanticscholar   +1 more source

Selection of Host Plasma Membrane Lipids by HIV‐1 Gag Protein

BioEssays, Volume 48, Issue 1, January 2026.
Enrichment of sphingomyelin in the HIV‐1 envelope arises from Gag binding to PI(4,5)P2, which triggers reorganization of plasma membrane sphingomyelin/cholesterol domains through unknown mechanisms. We propose that cholesterol‐mediated interleaflet coupling between sphingomyelin and PI(4,5)P2, rather than interdigitation, underlies Gag‐induced lipid ...
Nario Tomishige, Yves Mély, Toshihide Kobayashi   +2 more
wiley   +1 more source

Structural Insights into Escherichia coli Shiga Toxin (Stx) Glycosphingolipid Receptors of Porcine Renal Epithelial Cells and Inhibition of Stx-Mediated Cellular Injury Using Neoglycolipid-Spiked Glycovesicles

Microorganisms, 2019
Shiga toxin (Stx) producing Escherichia coli (STEC) cause the edema disease in pigs by releasing the swine-pathogenic Stx2e subtype as the key virulence factor.
Johanna Detzner, Caroline Gloerfeld, Gottfried Pohlentz, Nadine Legros, Hans-Ulrich Humpf, Alexander Mellmann, Helge Karch, Johannes Müthing   +7 more
doaj   +1 more source