GOLPH3 inhibits glioma cell apoptosis through the JNK signaling pathway [PDF]
Frontiers in GeneticsBackgroundGlioma, a primary intracranial tumor, is marked by high rates of mortality and disability, making it a significant health concern. Understanding the molecular mechanisms underlying glioma initiation and progression and identifying potential ...
Shao Xie +5 more
doaj +4 more sources
ATF-3/miR-590/GOLPH3 signaling pathway regulates proliferation of breast cancer [PDF]
BMC Cancer, 2018 Background Breast cancer is one of the leading causes of death in women worldwide. Fast growth is the important character of breast cancer, which makes sure the subsequent metastasize and invasion breast cancer.
Qiong Song +8 more
doaj +4 more sources
Involvement of GTPases and vesicle adapter proteins in Heparan sulfate biosynthesis: role of Rab1A, Rab2A and GOLPH3. [PDF]
FEBS JVesicle trafficking governs the biosynthesis of heparan sulfate (HS) by controlling the positioning of HS‐modifying enzymes within Golgi compartments. The proteins Rab1A and Rab2A play dynamic, compensatory roles that affect HS levels by influencing the transport of these enzymes.
Meneghetti MCZ +4 more
europepmc +4 more sources
FAP-a and GOLPH3 Are Hallmarks of DCIS Progression to Invasive Breast Cancer [PDF]
Frontiers in Oncology, 2019 Biological markers that could predict the progression of ductal carcinoma in-situ (DCIS) to invasive breast cancer (IDC) are required urgently for personalized therapy for patients diagnosed with DCIS.
Li-Na Yu +10 more
doaj +4 more sources
GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila [PDF]
Cell Death and Disease, 2022 The oncoprotein GOLPH3 (Golgi phosphoprotein 3) is an evolutionarily conserved phosphatidylinositol 4-phosphate effector, mainly localized to the Golgi apparatus, where it supports organelle architecture and vesicular trafficking. Overexpression of human
Anna Frappaolo +6 more
doaj +4 more sources
GOLPH3 keeps the Golgi residents at home [PDF]
Journal of Cell Biology, 2021 In this issue of JCB, Welch et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202106115) show that GOLPH3 mediates the sorting of numerous Golgi proteins into recycling COPI transport vesicles.
Lowe, Martin
core +5 more sources
High expression of GOLPH3 in esophageal squamous cell carcinoma correlates with poor prognosis. [PDF]
PLoS ONE, 2012 BackgroundWhether the expression of Golgi phosphoprotein 3 (GOLPH3) correlates with esophageal cancer tumorigenesis is currently unclear. The aim of this study was to examine GOLPH3 expression in patients with esophageal squamous cell cancer (ESCC) and ...
Jian-Hua Wang +11 more
doaj +4 more sources
Upregulation of GOLPH3 mediated by Bisphenol a promotes colorectal cancer proliferation and migration: evidence based on integrated analysis [PDF]
Frontiers in PharmacologyBackgroundThe interaction between environmental endocrine-disrupting chemicals, such as Bisphenol A (BPA), and their influence on cancer progression, particularly regarding the GOLPH3 gene in colorectal cancer, remains unclear.MethodsWe performed an ...
Lihua Chen +11 more
doaj +2 more sources
Role of GOLPH3 and GOLPH3L in the proliferation of human rhabdomyosarcoma [PDF]
Oncology Reports, 2011 GOLPH3 was originally identified by proteomic analyses of Golgi proteins localized in the trans-Golgi network. Recently, it was reported that GOLPH3 is up-regulated in various types of malignancies, including melanoma, colon cancer and lung cancer ...
116754 +31 more
core +4 more sources
GOLPH3 induces epithelial–mesenchymal transition via Wnt/β‐catenin signaling pathway in epithelial ovarian cancer [PDF]
Cancer Medicine, 2017 Golgi phosphoprotein 3 (GOLPH3), a newly recognized oncogene, is associated with tumor growth, metastasis, and poor prognosis in several types of cancer.
Jing Sun +8 more
doaj +2 more sources