Sequential Targeting Chondroitin Sulfate-Bilirubin Nanomedicine Attenuates Osteoarthritis via Reprogramming Lipid Metabolism in M1 Macrophages. [PDF]
Adv Sci (Weinh)M1 macrophages are excessively infiltrated and activated in the development of osteoarthritis. Here, a self‐assembled nanocarrier (designated as CSBN) based on chondroitin sulfate (CS)‐bilirubin (BR) conjugate is developed to reprogram lipid metabolism in macrophage activation by targeting the Golgi apparatus.
Deng C +10 more
europepmc +2 more sources
Golgi Apparatus Target Proteins in Gastroenterological Cancers: A Comprehensive Review of GOLPH3 and GOLGA Proteins [PDF]
Cells, 2023 The Golgi apparatus plays a central role in protein sorting, modification and trafficking within cells; its dysregulation has been implicated in various cancers including those affecting the GI tract.
Sandica Bucurica +4 more
doaj +2 more sources
GOLPH3 Participates in Mitochondrial Fission and Is Necessary to Sustain Bioenergetic Function in MDA-MB-231 Breast Cancer Cells [PDF]
CellsIn this study, we investigated the inter-organelle communication between the Golgi apparatus (GA) and mitochondria. Previous observations suggest that GA-derived vesicles containing phosphatidylinositol 4-phosphate (PI(4)P) play a role in mitochondrial ...
Catalina M. Polanco +9 more
doaj +2 more sources
GOLPH3 promotes endotoxemia-induced liver and kidney injury through Golgi stress-mediated apoptosis and inflammatory response [PDF]
Cell Death and Disease, 2023 Sepsis is a serious clinical condition characterized by a systemic inflammatory response, a leading cause of acute liver and kidney injury, and is associated with a high morbidity and mortality. Understanding the molecular mechanisms underlying the acute
Theodomir Dusabimana +5 more
doaj +2 more sources
Cancer Medicine, 2017 Golgi phosphoprotein 3 (GOLPH3), a newly recognized oncogene, is associated with tumor growth, metastasis, and poor prognosis in several types of cancer.
Jing Sun +8 more
doaj +2 more sources
The highly expressed <i>GOLPH3</i> in colorectal cancer cells activates smoothened to drive glycolysis and promote cancer cell growth and radiotherapy resistance. [PDF]
J Gastrointest OncolZhu K +6 more
europepmc +2 more sources
Frontiers in Oncology, 2021 BackgroundGolgi phosphoprotein 3 (GOLPH3) is an oncoprotein localized in the Golgi apparatus. Abnormal GOLPH3 expression is potentially related to carcinogenesis. However, the potential biological regulation network of GOLPH3 in lung adenocarcinoma (LUAD)
Tong Zhang +6 more
doaj +1 more source
Distinct Biochemical Pools of Golgi Phosphoprotein 3 in the Human Breast Cancer Cell Lines MCF7 and MDA-MB-231. [PDF]
PLoS ONE, 2016 Golgi phosphoprotein 3 (GOLPH3) has been implicated in the development of carcinomas in many human tissues, and is currently considered a bona fide oncoprotein.
María J Tenorio +10 more
doaj +1 more source
High expression of GOLPH3 in esophageal squamous cell carcinoma correlates with poor prognosis. [PDF]
PLoS ONE, 2012 BackgroundWhether the expression of Golgi phosphoprotein 3 (GOLPH3) correlates with esophageal cancer tumorigenesis is currently unclear. The aim of this study was to examine GOLPH3 expression in patients with esophageal squamous cell cancer (ESCC) and ...
Jian-Hua Wang +11 more
doaj +1 more source
Cell Death Discovery, 2022 In this study, we aimed to investigate whether and how Golgi phosphoprotein 3 (GOLPH3) facilitates colon cancer metastasis via the regulation of autophagy and epithelial–mesenchymal transition (EMT).
Li-Yun Gong +8 more
doaj +1 more source