GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila
Cell Death and Disease, 2022 The oncoprotein GOLPH3 (Golgi phosphoprotein 3) is an evolutionarily conserved phosphatidylinositol 4-phosphate effector, mainly localized to the Golgi apparatus, where it supports organelle architecture and vesicular trafficking. Overexpression of human
Anna Frappaolo +6 more
doaj +4 more sources
GOLPH3 modulates expression and alternative splicing of transcription factors associated with endometrial decidualization in human endometrial stromal cells [PDF]
PeerJ, 2023 Endometrial decidualization is a decidual tissue formed by the proliferation and re-differentiation of endometrial stroma stimulated by decidualization inducing factors. It is very important for the proper maintenance of pregnancy.
Suqin Zhu +7 more
doaj +3 more sources
Golgicide A induces pyroptosis of lung cancer stem cells by regulating dTGN formation via GOLPH3/MYO18A complex. [PDF]
Stem Cell Res TherLung cancer is a common malignant neoplasm, one of the leading causes of death worldwide. Cancer stem cells (CSCs) drive tumor recurrence, progression, and therapeutic resistance.
Zhang F +10 more
europepmc +2 more sources
The highly expressed <i>GOLPH3</i> in colorectal cancer cells activates smoothened to drive glycolysis and promote cancer cell growth and radiotherapy resistance. [PDF]
J Gastrointest OncolBackground Colorectal cancer (CRC) is a frequently diagnosed cancer across the world and has increased in prevalence over the last decade. This study aimed to assess the biological roles, influences on radiosensitivity, and possible molecular mechanism ...
Zhu K +6 more
europepmc +2 more sources
Cell Death and Disease, 2021 Cancer metastasis is the main cause of mortality associated with non-small-cell lung cancer (NSCLC), accounting for up to 70% of deaths among patients. The mechanisms underlying distal metastasis remain largely unknown.
Jun-Wei Song +9 more
doaj +2 more sources
GOLPH3 inhibition overcomes cisplatin resistance by restoring the glutathione/reactive oxygen species balance in the A549 non‑small cell lung cancer cell line. [PDF]
Oncol RepCisplatin resistance is common in non-small cell lung cancer (NSCLC); however, the molecular mechanisms remain unclear. The present study aimed to identify a new function of Golgi phosphoprotein 3 (GOLPH3) in NSCLC-associated cisplatin resistance.
Wei Q +6 more
europepmc +2 more sources
High expression of GOLPH3 in esophageal squamous cell carcinoma correlates with poor prognosis. [PDF]
PLoS ONE, 2012 BackgroundWhether the expression of Golgi phosphoprotein 3 (GOLPH3) correlates with esophageal cancer tumorigenesis is currently unclear. The aim of this study was to examine GOLPH3 expression in patients with esophageal squamous cell cancer (ESCC) and ...
Jian-Hua Wang +11 more
doaj +4 more sources
Technology in Cancer Research & Treatment, 2022 Golgi phosphoprotein 3 (GOLPH3), a highly conserved phosphatidylinositol 4-phosphate effector, is required for maintenance of Golgi architecture, vesicle trafficking, and Golgi glycosylation. GOLPH3 overexpression has been reported in several human solid
Maria Grazia Giansanti PhD +1 more
doaj +2 more sources
Addressing Heterogeneity in Genetic Studies of Cognitive Function: Insights from the ADSP‐PHC [PDF]
Alzheimers DementAbstract Background The Alzheimer's Disease Sequencing Project Phenotype Harmonization Consortium (ADSP‐PHC) released harmonized longitudinal cognition data across 12 studies enabling genomic analyses of AD related endophenotypes (ng00067.v11 via NIAGADS). We conducted genome‐wide analyses of common and rare variants using whole genome sequencing (WGS)
Yang J +6 more
europepmc +2 more sources
The EMBO Journal, 2021 Glycosphingolipids are important components of the plasma membrane where they modulate the activities of membrane proteins including signalling receptors.
Riccardo Rizzo +30 more
semanticscholar +7 more sources