Results 21 to 30 of about 1,218 (144)
Cell Death and Disease, 2021 Cancer metastasis is the main cause of mortality associated with non-small-cell lung cancer (NSCLC), accounting for up to 70% of deaths among patients. The mechanisms underlying distal metastasis remain largely unknown.
Jun-Wei Song +9 more
doaj +1 more source
Golgi Phosphoprotein 3 Promotes Colon Cancer Cell Metastasis Through STAT3 and Integrin α3 Pathways
Frontiers in Molecular Biosciences, 2022 Background: Golgi phosphoprotein 3 (GOLPH3) overexpression was recently reported to be associated with a poor clinical outcome in patients with colorectal cancer (CRC).
Anpei Huang +7 more
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PLoS ONE, 2021 BackgroundGolgi Phosphoprotein 3 (GOLPH3) has been implicated in the development of colorectal cancer (CRC). Nevertheless, the clinicopathological and prognostic roles of GOLPH3 in CRC remain undefined.
Tao Wang, Jiandong Fei, Shuangfa Nie
doaj +1 more source
Mechanisms of GOLPH3 associated with the progression of gastric cancer: a preliminary study. [PDF]
PLoS ONE, 2014 STUDY DESIGN: To investigate the specific mechanisms by which Golgi phosphoprotein 3 (GOLPH3) affects the progression of gastric cancer and to explore its clinical significance.
Jinzhen Peng +7 more
doaj +1 more source
The FEBS Journal, Volume 290, Issue 23, Page 5456-5474, December 2023., 2023 Signal peptide peptidase (SPP) and signal peptide peptidase‐like (SPPL) proteases are intramembrane aspartyl proteases involved in various cellular functions. Despite lacking high‐resolution structures, bioinformatic and biochemical data have shed light on their structure, localization, substrate recognition, cleavage mechanism, and function. Recently,
Sabine Höppner +2 more
wiley +1 more source
Novel strategies to reverse chemoresistance in colorectal cancer
Cancer Medicine, Volume 12, Issue 10, Page 11073-11096, May 2023., 2023 Chemoresistance is the major cause of treatment failure and disease relapse in colorectal cancer (CRC). In addition to some common reversal measures, some novel strategies have sprouted in recent years, including drug repurposing, gene therapy, protein inhibitor, natural herbal compounds, new drug delivery system, and combination therapy, which promise
Shu‐Chang Ma +7 more
wiley +1 more source
The structure of COPI vesicles and regulation of vesicle turnover
FEBS Letters, Volume 597, Issue 6, Page 819-835, March 2023., 2023 COPI‐coated vesicles mediate transport within the Golgi and retrograde transport from the Golgi to the endoplasmic reticulum. This review discusses the assembly and disassembly of COPI‐coated vesicles with an emphasis on the structure of the COPI coat components and regulatory factors including coatomer, Arf GTPases, and ArfGAPs and ArfGEFs.
Rebecca J. Taylor +2 more
wiley +1 more source
PLoS Genetics, 2014 The highly conserved Golgi phosphoprotein 3 (GOLPH3) protein has been described as a Phosphatidylinositol 4-phosphate [PI(4)P] effector at the Golgi. GOLPH3 is also known as a potent oncogene, commonly amplified in several human tumors.
Stefano Sechi +7 more
doaj +1 more source
Biopharmaceutics &Drug Disposition, Volume 44, Issue 1, Page 26-47, February 2023., 2023 Oligonucleotide therapeutics (OTs) are the promising modality for treating central nervous system (CNS) diseases because of their promising mode of action. However, due to the tight barrier function and complex physiological structure of the CNS, the efficient delivery of OTs to target the brain has been a major challenge.
Akihiko Goto +2 more
wiley +1 more source
Traffic, Volume 24, Issue 2, Page 52-75, February 2023., 2023 The model depicts the effect of acute Conserved Oligomeric Golgi (COG) depletion on Golgi homeostasis and vesicular trafficking. Upon COG4 depletion, t‐SNAREs, t‐Tethers, and Rab proteins remained at the Golgi while vesicular coat protein, glycosylation enzymes, and other Golgi resident proteins dissociated from the Golgi in nontethered CCD vesicles ...
Farhana Taher Sumya +3 more
wiley +1 more source