Results 41 to 50 of about 2,350 (202)
miR34a/GOLPH3 Axis abrogates Urothelial Bladder Cancer Chemoresistance via Reduced Cancer Stemness
Theranostics, 2017 Rationale: Chemoresistance and subsequent recurrence of human urothelial bladder cancer (UBC) is partially driven by a subpopulation of tumor initiating cells, namely cancer stem cells (CSCs). However, the underlying molecular mechanism in chemotherapy-induced CSCs enrichment and following chemoresistance and recurrence remains largely unclear. Methods:
Qing Zhang +10 more
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Sequential Targeting Chondroitin Sulfate-Bilirubin Nanomedicine Attenuates Osteoarthritis via Reprogramming Lipid Metabolism in M1 Macrophages. [PDF]
Adv Sci (Weinh)M1 macrophages are excessively infiltrated and activated in the development of osteoarthritis. Here, a self‐assembled nanocarrier (designated as CSBN) based on chondroitin sulfate (CS)‐bilirubin (BR) conjugate is developed to reprogram lipid metabolism in macrophage activation by targeting the Golgi apparatus.
Deng C +10 more
europepmc +2 more sources
Cell Death Discovery, 2022 In this study, we aimed to investigate whether and how Golgi phosphoprotein 3 (GOLPH3) facilitates colon cancer metastasis via the regulation of autophagy and epithelial–mesenchymal transition (EMT).
Li-Yun Gong +8 more
doaj +1 more source
Golgi Phosphoprotein 3 Promotes Colon Cancer Cell Metastasis Through STAT3 and Integrin α3 Pathways
Frontiers in Molecular Biosciences, 2022 Background: Golgi phosphoprotein 3 (GOLPH3) overexpression was recently reported to be associated with a poor clinical outcome in patients with colorectal cancer (CRC).
Anpei Huang +7 more
doaj +1 more source
GOLPH3 Links the Golgi, DNA Damage, and Cancer [PDF]
Cancer Research, 2015 Abstract GOLPH3 is the first example of an oncogene that functions in secretory trafficking at the Golgi. The discovery of GOLPH3′s roles in both cancer and Golgi trafficking raises questions about how GOLPH3 and the Golgi contribute to cancer.
Matthew D, Buschman +2 more
openaire +2 more sources
Increased Expression of GOLPH3 is Associated with the Proliferation of Prostate Cancer [PDF]
Journal of Cancer, 2015 Golgi phosphoprotein 3 (GOLPH3) is a metastasis-associated gene, however its role in cell proliferation of prostate cancer (PCa) has not yet been elucidated.The level of expression of GOLPH3 and other genes was examined by quantitative real-time PCR (QPCR) and western blot analysis.
Wenzhi Li +8 more
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GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer [PDF]
Nature, 2009 Genome-wide copy number analyses of human cancers identified a frequent 5p13 amplification in several solid tumour types, including lung (56%), ovarian (38%), breast (32%), prostate (37%) and melanoma (32%). Here, using integrative analysis of a genomic profile of the region, we identify a Golgi protein, GOLPH3, as a candidate targeted for ...
Scott, Kenneth L. +18 more
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Cell Death and Disease, 2021 Cancer metastasis is the main cause of mortality associated with non-small-cell lung cancer (NSCLC), accounting for up to 70% of deaths among patients. The mechanisms underlying distal metastasis remain largely unknown.
Jun-Wei Song +9 more
doaj +1 more source
Correlation of GOLPH3 Gene with Wnt Signaling Pathway in Human Colon Cancer Cells [PDF]
Journal of Cancer, 2016 Overexpression of GOLPH3 in colorectal cancer tissue may promote cell proliferation and activate the Wnt signaling pathway. We investigated the correlation between GOLPH3 gene expression and the Wnt signaling pathway to explore the mechanism of the overexpression of GOLPH3 gene which promotes proliferation in human colon cancer cells.We measured ...
Chengzhi Qiu +5 more
openalex +3 more sources
PLoS ONE, 2021 BackgroundGolgi Phosphoprotein 3 (GOLPH3) has been implicated in the development of colorectal cancer (CRC). Nevertheless, the clinicopathological and prognostic roles of GOLPH3 in CRC remain undefined.
Tao Wang, Jiandong Fei, Shuangfa Nie
doaj +1 more source