Results 51 to 60 of about 1,450 (167)

GOLPH3 Overexpression is Closely Correlated with Poor Prognosis in Human Non-Small Cell Lung Cancer and Mediates its Metastasis Through Upregulating MMP-2 and MMP-9

Cellular Physiology and Biochemistry, 2015
Background/Aims: Golgi phosphoprotein 3 (GOLPH3) is a newly reported oncogene that plays a significant role in regulating cell growth. Recent research has shown that overexpression of GOLPH3 is correlated with patient survival and M classification in ...
Ran Wang, Zun-fu Ke, Fen Wang, Wen-hui Zhang, Yue-feng Wang, Shu-hua Li, Lian-tang Wang   +6 more
doaj   +1 more source

The knocking down of the oncoprotein Golgi phosphoprotein 3 in T98G cells of glioblastoma multiforme disrupts cell migration by affecting focal adhesion dynamics in a focal adhesion kinase-dependent manner.

PLoS ONE, 2019
Golgi phosphoprotein 3 (GOLPH3) is a conserved protein of the Golgi apparatus that in humans has been implicated in tumorigenesis. However, the precise function of GOLPH3 in malignant transformation is still unknown.
Cecilia Arriagada, Charlotte Luchsinger, Alexis E González, Tomás Schwenke, Gloria Arriagada, Hugo Folch, Pamela Ehrenfeld, Patricia V Burgos, Gonzalo A Mardones   +8 more
doaj   +1 more source

Human Golgi phosphoprotein 3 is an effector of RAB1A and RAB1B.

PLoS ONE, 2020
Golgi phosphoprotein 3 (GOLPH3) is a peripheral membrane protein localized at the trans-Golgi network that is also distributed in a large cytosolic pool.
Viviana A Cavieres, Cristóbal Cerda-Troncoso, Andrés Rivera-Dictter, Rodrigo I Castro, Charlotte Luchsinger, Natacha Santibañez, Patricia V Burgos, Gonzalo A Mardones   +7 more
doaj   +1 more source

Golgi Phosphoprotein 3 Promotes Wls Recycling and Wnt Secretion in Glioma Progression

Cellular Physiology and Biochemistry, 2018
Background/Aims: Golgi phosphoprotein 3 (GOLPH3) plays pro-malignancy roles in several types of cancer. However, the molecular mechanism underlying GOLPH3 promoting tumor progression remains poorly understood.
Dong Lu, Hao Zhang, Jiale Fu, Yanhua Qi, Xu Wang, Shishuang Wu, Xiuping Zhou, Rutong Yu   +7 more
doaj   +1 more source

Golgi Phosphoprotein 3 Mediates Radiation-Induced Bystander Effect via ERK/EGR1/TNF-α Signal Axis

Antioxidants, 2022
The radiation-induced bystander effect (RIBE), an important non-targeted effect of radiation, has been proposed to be associated with irradiation-caused secondary cancers and reproductive damage beyond the irradiation-treated area after radiotherapy ...
Feng Qin, Guodong Chen, Kwan Ngok Yu, Miaomiao Yang, Wei Cao, Peizhong Kong, Shengjie Peng, Mingyu Sun, Lili Nie, Wei Han   +9 more
doaj   +1 more source

GOLPH3 and GOLPH3L are broad-spectrum COPI adaptors for sorting into intra-Golgi transport vesicles

bioRxiv, 2021
Glycosylation is a diverse and abundant modification of proteins, lipids and RNA. The fidelity of glycosylation is, in part, assured by the correct compartmentalisation of Golgi-resident glycosylation enzymes within the Golgi stack.
Lawrence G. Welch, S. Peak-Chew, Farida Begum, T. Stevens, S. Munro   +4 more
semanticscholar   +1 more source

Role of GOLPH3 and GOLPH3L in the proliferation of human rhabdomyosarcoma

Oncology Reports, 2011
GOLPH3 was originally identified by proteomic analyses of Golgi proteins localized in the trans-Golgi network. Recently, it was reported that GOLPH3 is up-regulated in various types of malignancies, including melanoma, colon cancer and lung cancer. However, the mechanism through which GOLPH3 is involved in the pathogenesis of rhabdomyosarcoma remains ...
Osamu, Kunigou, Hiroko, Nagao, Naoya, Kawabata, Yasuhiro, Ishidou, Satoshi, Nagano, Shingo, Maeda, Setsuro, Komiya, Takao, Setoguchi   +7 more
openaire   +3 more sources

Increased Expression of GOLPH3 is Associated with the Proliferation of Prostate Cancer [PDF]

Journal of Cancer, 2015
Golgi phosphoprotein 3 (GOLPH3) is a metastasis-associated gene, however its role in cell proliferation of prostate cancer (PCa) has not yet been elucidated.The level of expression of GOLPH3 and other genes was examined by quantitative real-time PCR (QPCR) and western blot analysis.
Li, Wenzhi, Guo, Fengfu, Gu, Meng, Wang, Guangjian, He, Xiangfei, Zhou, Juan, Peng, Yubing, Wang, Zhong, Wang, Xiang   +8 more
openaire   +2 more sources

The GOLPH3 pathway regulates Golgi shape and function and is activated by DNA damage

Frontiers in Neuroscience, 2015
The Golgi protein GOLPH3 binds to PtdIns(4)P and MYO18A, linking the Golgi to the actin cytoskeleton. The GOLPH3 pathway is essential for vesicular trafficking from the Golgi to the plasma membrane.
Matthew D. Buschman, Mengke eXing, Seth J Field   +2 more
doaj   +1 more source

GOLPH3 Promotes Cancer Growth by Interacting With STIP1 and Regulating Telomerase Activity in Pancreatic Ductal Adenocarcinoma

Frontiers in Oncology, 2020
Overexpression of Golgi phosphoprotein 3 (GOLPH3) predicts poor prognosis and is a potential therapeutic target in pancreatic ductal adenocarcinoma (PDAC).
Kebing Wang, Shuai Jiang, Anpei Huang, Ying Gao, Baogang Peng, Zhi Li, Wenbin Ma, Zhou Songyang, Shihong Zhang, Meifang He, Wen Li   +10 more
doaj   +1 more source