Results 51 to 60 of about 1,218 (144)
Phosphoinositide Metabolism: Biochemistry, Physiology and Genetic Disorders
Journal of Inherited Metabolic Disease, Volume 48, Issue 2, March 2025.ABSTRACT Phosphatidylinositol, a glycerophospholipid with a myo‐inositol head group, can form seven different phosphoinositides (PItds) by phosphorylation at inositol carbons 3, 4 and/or 5. Over 50 kinases and phosphatases participate in PItd metabolism, creating an interconnected PItd network that allows for precise temporal and spatial regulation of ...
Francis Rossignol +2 more
wiley +1 more source
Diagnostic Pathology, 2012 Background To investigate the expression of Golgi phosphoprotein-3 (GOLPH3) in prostate cancer and determine its prognostic value. Methods Immunohistochemical staining for GOLPH3 was performed on tissue microarrays of 342 prostate patients.
Hua Xing +7 more
doaj +1 more source
Organelle‐Targeting Nanoparticles
Advanced Science, Volume 12, Issue 7, February 17, 2025.This review examines nanoparticle‐based therapies targeting organelles like the nucleus, mitochondria, and lysosomes. Nanoparticle design, targeting strategies, and their applications in treating diseases linked to organelle dysfunction are discussed, highlighting the potential for improved treatment outcomes and reduced off‐target effects.
John Soukar +2 more
wiley +1 more source
Genetic Markers of Postmortem Brain Iron
Journal of Neurochemistry, Volume 169, Issue 2, February 2025.Iron is essential for neural development and physiology but also catalyzes oxidative damage implicated in neurodegeneration. We performed a genome‐wide association study of postmortem brain iron. Promising loci were followed up for replication and mapped to genes for cortical transcriptomic and epigenetic analysis.
Marilyn C. Cornelis +4 more
wiley +1 more source
Journal of Translational Medicine, 2012 Background Overexpression of GOLPH3 (Golgi phosphoprotein 3, 34 kDa) is associated with the progression of many solid tumor types leading to an unfavorable clinical outcome.
Li Huan +7 more
doaj +1 more source
CAAI Transactions on Intelligence Technology, Volume 9, Issue 6, Page 1572-1586, December 2024.Abstract The prevalence of digestive system tumours (DST) poses a significant challenge in the global crusade against cancer. These neoplasms constitute 20% of all documented cancer diagnoses and contribute to 22.5% of cancer‐related fatalities. The accurate diagnosis of DST is paramount for vigilant patient monitoring and the judicious selection of ...
Lin Zhou +6 more
wiley +1 more source
Rab1 interacts with GOLPH3 and controls Golgi structure and contractile ring constriction during cytokinesis in Drosophila melanogaster [PDF]
Open Biology, 2017 Cytokinesis requires a tight coordination between actomyosin ring constriction and new membrane addition along the ingressing cleavage furrow. However, the molecular mechanisms underlying vesicle trafficking to the equatorial site and how this process is
Stefano Sechi +8 more
doaj +1 more source
The role of gastric mucins and mucin‐related glycans in gastric cancers
Cancer Science, Volume 115, Issue 9, Page 2853-2861, September 2024.Gastric mucins shield the stomach lining from acid and bacteria, with alterations seen in Helicobacter pylori infection and gastric cancer. The review explores this relationship, potential mechanisms in carcinogenesis, and challenges in targeting tumor‐specific glycans for treatment, offering insights into novel approaches for gastric cancer therapy ...
Junya Arai +5 more
wiley +1 more source
Journal of Lipid Research, 2019 GOLPH3 is a peripheral membrane protein localized to the Golgi and its vesicles, but its purpose had been unclear. We found that GOLPH3 binds specifically to the phosphoinositide phosphatidylinositol(4)phosphate [PtdIns(4)P], which functions at the Golgi
Ramya S. Kuna, Seth J. Field
doaj
Luteolin: A promising multifunctional natural flavonoid for human diseases
Phytotherapy Research, Volume 38, Issue 7, Page 3417-3443, July 2024.Luteolin, a flavonoid polyphenolic compound, has the ability to target multiple targets and pathways of the complex pathogenesis of related diseases, showing unique characteristics and benefits in the prevention or treatment of human diseases. Abstract Natural products are closely associated with human health.
Mingtao Zhu +9 more
wiley +1 more source