Results 21 to 30 of about 14,390 (160)
Research in Cardiovascular Medicine, 2023 Context: Interleukin-6 (IL-6), a pro-inflammatory cytokine, plays an important role in the pathogenesis of myocardial hypertrophy. By integrating its membrane receptor complex (gp80), IL-6 activates the signal guidance components (gp130) and activates ...
Ahad Nikkholgh +3 more
doaj +1 more source
Roads to Stat3 Paved with Cadherins
Cells, 2022 The engagement of cadherins, cell-to-cell adhesion proteins, triggers a dramatic increase in the levels and activity of the Rac/Cdc42 GTPases, through the inhibition of proteasomal degradation.
Hanad Adan, Juliet Daniel, Leda Raptis
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gp130 Controls Cardiomyocyte Proliferation and Heart Regeneration [PDF]
Circulation, 2020 Background: A key cause of the high mortality of cardiovascular diseases is the cardiomyocyte inability to renew after cardiac injury. As a promising strategy to supplement functional myocytes for cardiac repair, there is a pressing need to understand the cellular and molecular mechanisms of heart regeneration.
Yandong Li +11 more
openaire +2 more sources
Cross-talk among gp130 Cytokines in Adipocytes [PDF]
Journal of Biological Chemistry, 2005 The interleukin-6 (IL-6) family of cytokines is a family of structurally and functionally related proteins, including IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), and cardiotrophin-1 (CT-1). These proteins are also known as gp130 cytokines because they all share gp130 as a common transducer ...
Sanjin, Zvonic +4 more
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GP130 Cytokines in Breast Cancer and Bone [PDF]
Cancers, 2020 Breast cancer cells have a high predilection for skeletal homing, where they may either induce osteolytic bone destruction or enter a latency period in which they remain quiescent. Breast cancer cells produce and encounter autocrine and paracrine cytokine signals in the bone microenvironment, which can influence their behavior in multiple ways.
Tolu Omokehinde, Rachelle W. Johnson
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Frontiers in Immunology, 2018 gp130 cytokines are differentially involved in regulating the T helper (H) 17-driven pathogenesis of experimental autoimmune encephalomyelitis (EAE), the animal model of human multiple sclerosis.
Kristian Holz +11 more
doaj +1 more source
Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting
Journal of Cachexia, Sarcopenia and Muscle, 2022 Background Sepsis and inflammation can cause intensive care unit‐acquired weakness (ICUAW). Increased interleukin‐6 (IL‐6) plasma levels are a risk factor for ICUAW. IL‐6 signalling involves the glycoprotein 130 (gp130) receptor and the JAK/STAT‐pathway,
Lukas Zanders +13 more
doaj +1 more source
CD9 exacerbates pathological cardiac hypertrophy through regulating GP130/STAT3 signaling pathway
iScience, 2023 Summary: CD9 is a member of the tetraspanin protein family, which has been widely studied in inflammation and cancer, but not in pathological cardiac hypertrophy.
Yue Li +12 more
doaj +1 more source
Signaling Through gp130 Compromises Suppressive Function in Human FOXP3+ Regulatory T Cells
Frontiers in Immunology, 2019 The CD4+FOXP3+ regulatory T cell (Treg) subset is an indispensable mediator of immune tolerance. While high and stable expression of the transcription factor FOXP3 is considered a hallmark feature of Treg cells, our previous studies have demonstrated ...
Khalid Bin Dhuban +9 more
doaj +1 more source
The role of cytokines in ovarian cancer drug resistance. [PDF]
Int J CancerAbstract Ovarian cancer is the leading cause of death among women diagnosed with female reproductive system cancers. While significant advances have been made in treating various types of cancer, progress in ovarian cancer treatment over the past 20 years has been minimal, and the treatment course of ovarian cancer is not linear. Although many patients
Wang L +7 more
europepmc +2 more sources