Results 81 to 90 of about 14,390 (160)

Intermittent Fasting‐Induced Orm2 Promotes Adipose Browning via the GP130/IL23R‐p38 Cascade

Advanced Science
Intermittent fasting (IF) plays a critical role in mitigating obesity, yet the precise biological mechanisms require further elucidation. Here Orosomucoid 2 (Orm2) is identified as an IF‐induced hepatokine that stimulates adipose browning.
Xuejuan Zhu, Xinran Wang, Jingang Wang, Lei Du, Zhen‐Ning Zhang, Donglei Zhou, Junfeng Han, Bing Luan   +7 more
doaj   +1 more source

Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency

Nature Communications
IL-11 and IL-6 activate signalling via assembly of the cell surface receptor gp130; however, it is unclear how signals are transmitted across the membrane to instruct cellular responses.
Scott Gardner, Yibo Jin, Paul K. Fyfe, Tomas B. Voisin, Junel Sotolongo Bellón, Elizabeth Pohler, Jacob Piehler, Ignacio Moraga, Doryen Bubeck   +8 more
doaj   +1 more source

Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth

EMBO Molecular Medicine, 2019
Excessive signaling through gp130, the shared receptor for the interleukin (IL)6 family of cytokines, is a common hallmark in solid malignancies and promotes their progression.
Pathum Thilakasiri, Jennifer Huynh, Ashleigh R Poh, Chin Wee Tan, Tracy L Nero, Kelly Tran, Adam C Parslow, Shoukat Afshar‐Sterle, David Baloyan, Natalie J Hannan, Michael Buchert, Andrew Mark Scott, Michael DW Griffin, Frederic Hollande, Michael W Parker, Tracy L Putoczki, Matthias Ernst, Ashwini L Chand   +17 more
doaj   +1 more source

Interleukin-6 family of cytokines and gp130 [PDF]

Blood, 1995
T, Kishimoto, S, Akira, M, Narazaki, T, Taga   +3 more
openaire   +2 more sources

Untersuchungen zur gp130/Jak1-Interaktion

, 2000
The common receptor subunit gp130 is essential for cellular responses following stimulation with IL-6-type cytokines. Signal transduction via gp130 occurs through activation of constitutively associated kinases of the Janus family (Jak1, Jak2 and Tyk2).
openaire   +1 more source

The role and mechanism of IL‑35 in myasthenia gravis (Review). [PDF]

Int J Mol Med
Mao J, Zhang LM, Zhu YL, Gao SJ, Liu MW.
europepmc   +1 more source

The role of IL-11 in chronic diseases. [PDF]

Front Immunol
Zhang J, Leng Y, Li W, Wang B, Yang B, Li W.   +5 more
europepmc   +1 more source

[Why C-reactive protein is (usually) not high in SLE]. [PDF]

Z Rheumatol
Klapproth E, Hempel M, Leuchten N, Rose-John S, Korb-Pap A, Aringer M.   +5 more
europepmc   +1 more source

iBody-mediated tuning of synthetic cytokine receptor activation via rational nanobody interface engineering. [PDF]

MAbs
Kunze R, Navratil F, Beichert J, Geyer F, Floss DM, Kolmar H, Scheller J, Pudewell S.   +7 more
europepmc   +1 more source

Regulation of immunological equilibrium by IL-6/STAT3 in glaucomatous irises and its effect on filtering bleb success. [PDF]

Indian J Ophthalmol
Sinha N, Dubey S, Pegu J, Sangwan VS, Tiwari A.   +4 more
europepmc   +1 more source