Results 61 to 70 of about 6,737,339 (379)

Beam effect on electromagnetic ion-cyclotron waves with general loss ? cone distribution function in an anisotropic plasma-particle aspect analysis [PDF]

open access: yes, 2007
International audienceThe effect of upgoing ion beam and temperature anisotropy on the dispersion relation, growth rate, parallel and perpendicular resonant energies, and marginal instability of the electromagnetic ion cyclotron (EMIC) waves, with ...
Ahirwar, G., Tiwari, M. S., Varma, P.
core   +2 more sources

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Roles of dual specificity tyrosine-phosphorylation-regulated kinase 2 in nervous system development and disease

open access: yesFrontiers in Neuroscience, 2022
Dual specificity tyrosine-phosphorylation-regulated kinases (DYRKs) are a group of conserved eukaryotic kinases phosphorylating tyrosine, serine, and threonine residues. The human DYRK family comprises 5 members (DYRK1A, DYRK1B, DYRK2, DYRK3, and DYRK4).
Gabriel Nicolás Santos-Durán   +1 more
doaj   +1 more source

Down Syndrome Cell Adhesion Molecule (DSCAM) Associates with Uncoordinated-5C (UNC5C) in Netrin-1-mediated Growth Cone Collapse*

open access: yesJournal of Biological Chemistry, 2012
Background: Coordination of the signaling cascades downstream of netrin receptors is essential in axon guidance. Results: DSCAM collaborates with UNC5C to mediate netrin-1-induced axon growth cone collapse through the assembly of a signaling complex ...
Anish A. Purohit   +6 more
semanticscholar   +1 more source

A conic manifold perspective of elliptic operators on graphs

open access: yes, 2007
We give a simple, explicit, sufficient condition for the existence of a sector of minimal growth for second order regular singular differential operators on graphs. We specifically consider operators with a singular potential of Coulomb type and base our
Birkhoff   +14 more
core   +1 more source

Retrograde Ret signaling controls sensory pioneer axon outgrowth

open access: yeseLife, 2019
The trafficking mechanisms and transcriptional targets downstream of long-range neurotrophic factor ligand/receptor signaling that promote axon growth are incompletely understood. Zebrafish carrying a null mutation in a neurotrophic factor receptor, Ret,
Adam Tuttle   +4 more
doaj   +1 more source

Much More Than a Scaffold: Cytoskeletal Proteins in Neurological Disorders

open access: yesCells, 2020
Recent observations related to the structure of the cytoskeleton in neurons and novel cytoskeletal abnormalities involved in the pathophysiology of some neurological diseases are changing our view on the function of the cytoskeletal proteins in the ...
Diana C. Muñoz-Lasso   +3 more
doaj   +1 more source

The Neuron Navigators: Structure, function, and evolutionary history

open access: yesFrontiers in Molecular Neuroscience, 2023
Neuron navigators (Navigators) are cytoskeletal-associated proteins important for neuron migration, neurite growth, and axon guidance, but they also function more widely in other tissues.
Regina M. Powers   +5 more
doaj   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

open access: yesFEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez   +5 more
wiley   +1 more source

Revisiting Netrin-1: One Who Guides (Axons)

open access: yesFrontiers in Cellular Neuroscience, 2018
Proper patterning of the nervous system requires that developing axons find appropriate postsynaptic partners; this entails microns to meters of extension through an extracellular milieu exhibiting a wide range of mechanical and chemical properties. Thus,
Nicholas P. Boyer   +2 more
doaj   +1 more source

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