Results 61 to 70 of about 1,125 (150)

Formate Reduces Ischemic Injury in Female Hearts Lacking Alcohol Dehydrogenase 5

FASEB BioAdvances, Volume 7, Issue 12, December 2025.
Exogenous formate administration reduces myocardial ischemic injury in intact alcohol dehydrogenase 5 knockout (ADH5−/−) female mice, but not in intact or ovariectomized wild‐type female mice. One‐carbon metabolism may play an intermediate role. This graphic was generated using BioRender.
Haley Garbus‐Grant, Obialunanma V. Ebenebe‐Kasonde, Raihan Kabir, Mark J. Kohr   +3 more
wiley   +1 more source

Meta‐Analysis of Iron Excess Stress in Rice: Genes and Mechanisms of Tolerance to Acidic Soil

Physiologia Plantarum, Volume 177, Issue 5, September/October 2025.
ABSTRACT Iron toxicity, predominantly stemming from excessive levels of ferrous iron (Fe2+) in acidic soils, poses a considerable challenge for crop production. Hypoxic conditions induced by waterlogging can exacerbate Fe2+ availability, which significantly impacts the cultivation and productivity of rice (Oryza sativa), a staple food for millions ...
Divya Gupta, Sanjib Kumar Panda, Petra Bauer   +2 more
wiley   +1 more source

The Role of Protein S-Nitrosylation in Protein Misfolding-Associated Diseases

Life, 2021
Abnormal and excessive nitrosative stress contributes to neurodegenerative disease associated with the production of pathological levels of misfolded proteins.
Yun-Jin Ju, Hye-Won Lee, Ji-Woong Choi, Min-Sik Choi   +3 more
doaj   +1 more source

Two Subunits of the Rpd3 Histone Deacetylase Complex of Cochliobolus heterostrophus Are Essential for Nitrosative Stress Response and Virulence, and Interact With Stress‐Response Regulators ChHog1 and ChCrz1

Molecular Plant Pathology, Volume 26, Issue 8, August 2025.
ChPho23 and ChSds3, two components of the Rpd3 histone deacetylase complex associated with ChHog1, regulate the transcription factor ChCrz1 and modulate the nitrosative stress response and virulence in Cochliobolus heterostrophus. ABSTRACT Southern corn leaf blight (SCLB), caused by Cochliobolus heterostrophus, is a destructive disease in maize‐growing
Jinyu Fan, Jun Hu, Dan Li, Yuanyuan Tian, Mengjiao Jia, Tianye Liang, Hongyu Pan, Xianghui Zhang   +7 more
wiley   +1 more source

Comparative Transcriptome Reveals ART1‐Dependent Regulatory Pathways for Fe Toxicity Response in Rice Roots

Physiologia Plantarum, Volume 177, Issue 4, July/August 2025.
ABSTRACT Iron (Fe) is an essential element for plants, but an excess supply can have detrimental effects. Fe toxicity induces complex physiological and genetic responses, and due to this complexity, the knowledge of transcriptional regulatory mechanisms under Fe toxicity is very limited.
Yoshiaki Ueda, Naoki Yamaji, Matthias Wissuwa   +2 more
wiley   +1 more source

Data from Hepatocarcinogenesis Driven by GSNOR Deficiency Is Prevented by iNOS Inhibition

, 2023
<div>Abstract<p>Hepatocellular carcinoma (HCC) is one of the most common and deadly human cancers and it remains poorly managed. Human HCC development is often associated both with elevated expression of inducible nitric oxide synthase (iNOS) and with genetic deletion of the major denitrosylase <i>S</i>-nitrosoglutathione ...
Limin Liu, Martha A. Hanes, Wei Wei, Chi-Hui Tang   +3 more
openaire   +1 more source

V‐ATPases and amino acid catabolism are strongly disturbed in the roots of autophagy mutants in Arabidopsis, impacting water use efficiency and tricarboxylic acid metabolism

The Plant Journal, Volume 123, Issue 2, July 2025.
Significance Statement This study reveals that V‐ATPases were less abundant in the roots of autophagy mutants than in wild type. This V‐ATPases deficit, associated with lower root water contents and lower nitrate, magnesium, and potassium concentrations, indicates that disturbance of cellular ion and water management in autophagy mutants was likely ...
Maxence James, Jacques Trouverie, Benoit Bernay, Anne Marmagne, Fabien Chardon, Marin‐Pierre Gemin, Philippe Etienne, Céline Masclaux‐Daubresse   +7 more
wiley   +1 more source

Flavonoid-Deficient Mutants in Grass Pea (Lathyrus sativus L.): Genetic Control, Linkage Relationships, and Mapping with Aconitase and S-Nitrosoglutathione Reductase Isozyme Loci

The Scientific World Journal, 2012
Two flavonoid-deficient mutants, designated as fldL-1 and fldL-2, were isolated in EMS-mutagenized (0.15%, 10 h) M2 progeny of grass pea (Lathyrus sativus L.).
Dibyendu Talukdar
doaj   +1 more source

The Ever‐Expanding Influence of the Endothelial Nitric Oxide Synthase

Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 5, May 2025.
ABSTRACT Nitric oxide (NO) generated by the endothelial NO synthase (eNOS) plays an essential role in the maintenance of vascular homeostasis and the prevention of vascular inflammation. There are a myriad of mechanisms that regulate the activity of the enzyme that may prove to represent interesting therapeutic opportunities.
Riham Rafea, Mauro Siragusa, Ingrid Fleming   +2 more
wiley   +1 more source

Promoting Roles of Melatonin in Adventitious Root Development of Solanum lycopersicum L. by Regulating Auxin and Nitric Oxide Signaling

Frontiers in Plant Science, 2016
Melatonin (MT) plays integral roles in regulating several biological processes including plant growth, seed germination, flowering, senescence and stress responses.
Dan eWen, Biao eGong, Shasha eSun, Shiqi eLiu, Xiufeng eWang, Min eWei, Fengjuan eYang, Yan eLi, Qinghua eShi   +8 more
doaj   +1 more source