Results 1 to 10 of about 22,089 (168)
RIM-Binding Proteins Are Required for Normal Sound-Encoding at Afferent Inner Hair Cell Synapses
Frontiers in Molecular Neuroscience, 2021 The afferent synapses between inner hair cells (IHC) and spiral ganglion neurons are specialized to faithfully encode sound with sub-millisecond precision over prolonged periods of time.
Stefanie Krinner +10 more
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Overloaded Adeno-Associated Virus as a Novel Gene Therapeutic Tool for Otoferlin-Related Deafness
Frontiers in Molecular Neuroscience, 2021 Hearing impairment is the most common sensory disorder in humans. So far, rehabilitation of profoundly deaf subjects relies on direct stimulation of the auditory nerve through cochlear implants.
Vladan Rankovic +23 more
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Hearing loss in mice with disruption of auditory epithelial patterning in the cochlea
Frontiers in Cell and Developmental Biology, 2022 In the cochlear auditory epithelia, sensory hair and supporting cells are arranged in a checkerboard-like mosaic pattern, which is conserved across a wide range of species.
Sayaka Katsunuma +7 more
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Survival of auditory hair cells [PDF]
Cell and Tissue Research, 2015 The inability of mammals to regenerate auditory hair cells creates a pressing need to understand the means of enhancing hair cell survival following insult or injury. Hair cells are easily damaged by noise exposure, by ototoxic medications and as a consequence of aging processes, all of which lead to progressive and permanent hearing impairment as hair
Michelle L, Seymour, Fred A, Pereira
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Research Progress on the Mechanism of Cochlear Hair Cell Regeneration
Frontiers in Cellular Neuroscience, 2021 Mammalian inner ear hair cells do not have the ability to spontaneously regenerate, so their irreversible damage is the main cause of sensorineural hearing loss.
Shan Xu, Ning Yang
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The developmental genetics of auditory hair cells [PDF]
Human Molecular Genetics, 2004 Loss of auditory hair cells (AHCs) is a major cause of human deafness. Considerable effort has been devoted to unraveling how these mechanotransducers of sound are specified, with a view to correcting hearing loss by gene or stem cell therapies. Recent work on signaling cascades, particularly lateral inhibition and planar cell polarity, has begun to ...
R David, Hawkins, Michael, Lovett
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Hearing Recovery Induced by DNA Demethylation in a Chemically Deafened Adult Mouse Model
Frontiers in Cellular Neuroscience, 2022 Functional hair cell regeneration in the adult mammalian inner ear remains challenging. This study aimed to study the function of new hair cells induced by a DNA demethylating agent 5-azacytidine.
Xin Deng, Zhengqing Hu, Zhengqing Hu
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Mechanisms of Active Hair Bundle Motion in Auditory Hair Cells [PDF]
The Journal of Neuroscience, 2002 Sound stimuli vibrate the hair bundles on auditory hair cells, but the resulting motion attributable to the mechanical stimulus may be modified by forces intrinsic to the bundle, which drive it actively. One category of active hair bundle motion has properties similar to fast adaptation of the mechanotransducer channels and is explicable if gating of ...
A J, Ricci, A C, Crawford, R, Fettiplace
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Conserved and Divergent Principles of Planar Polarity Revealed by Hair Cell Development and Function
Frontiers in Neuroscience, 2021 Planar polarity describes the organization and orientation of polarized cells or cellular structures within the plane of an epithelium. The sensory receptor hair cells of the vertebrate inner ear have been recognized as a preeminent vertebrate model ...
Michael R. Deans, Michael R. Deans
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Notch Signaling and the Emergence of Auditory Hair Cells [PDF]
Archives of Otolaryngology–Head & Neck Surgery, 2000 Recent insights into the mechanisms that determine a hair cell's fate have emerged from studies on invertebrate sensory organs and the avian inner ear. These mechanisms have important implications for our understanding of the possible therapeutic management of sensorineural deafness.
J, Weir, M N, Rivolta, M C, Holley
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