Results 1 to 10 of about 135,772 (323)

Molecular Regulation of Auditory Hair Cell Death and Approaches to Protect Sensory Receptor Cells and/or Stimulate Repair Following Acoustic Trauma

Frontiers in Cellular Neuroscience, 2015
Loss of auditory sensory hair cells is the most common cause of hearing loss. This review addresses the signaling pathways that are involved in the programmed and necrotic cell death of auditory hair cells that occur in response to ototoxic and traumatic
Christine T DINH, Stefania eGONCALVES, Esperanza eBAS, Thomas R VAN DE WATER, Azel eZINE, Azel eZINE   +5 more
doaj   +2 more sources

Control of Exocytosis by Synaptotagmins and Otoferlin in Auditory Hair Cells [PDF]

The Journal of Neuroscience, 2010
In pre-hearing mice, vesicle exocytosis at cochlear inner hair cell (IHC) ribbon synapses is triggered by spontaneous Ca2+spikes. At the onset of hearing, IHC exocytosis is then exclusively driven by graded potentials, and is characterized by higher Ca2+efficiency and improved synchronization of vesicular release. The molecular players involved in this
Beurg, Maryline, Michalski, Nicolas, Safieddine, Saaid, Bouleau, Yohan, Schneggenburger, Ralf, Chapman, Edwin R, Petit, Christine, Dulon, Didier   +7 more
openaire   +8 more sources

The lhfpl5 Ohnologs lhfpl5a and lhfpl5b Are Required for Mechanotransduction in Distinct Populations of Sensory Hair Cells in Zebrafish

Frontiers in Molecular Neuroscience, 2020
Hair cells sense and transmit auditory, vestibular, and hydrodynamic information by converting mechanical stimuli into electrical signals. This process of mechano-electrical transduction (MET) requires a mechanically gated channel localized in the apical
Timothy Erickson, Timothy Erickson, Itallia V. Pacentine, Alexandra Venuto, Rachel Clemens, Teresa Nicolson   +5 more
doaj   +2 more sources

Endolymphatic hydrops and cochlear synaptopathy after noise exposure are distinct sequelae of hair cell stereociliary bundle trauma [PDF]

Scientific Reports
Endolymphatic hydrops, increased endolymphatic fluid within the cochlea, is the key pathologic finding in patients with Meniere’s disease, a disease of episodic vertigo, fluctuating hearing loss, tinnitus, and aural fullness.
Michelle L. Fong, Connie B. Paik, Patricia M. Quiñones, Clayton B. Walker, Michael J. Serafino, Dorothy W. Pan, Eduardo Martinez, Juemei Wang, Grady W. Phillips, Brian E. Applegate, Michael Anne Gratton, John S. Oghalai   +11 more
doaj   +2 more sources

RIM-Binding Proteins Are Required for Normal Sound-Encoding at Afferent Inner Hair Cell Synapses

Frontiers in Molecular Neuroscience, 2021
The afferent synapses between inner hair cells (IHC) and spiral ganglion neurons are specialized to faithfully encode sound with sub-millisecond precision over prolonged periods of time.
Stefanie Krinner, Stefanie Krinner, Stefanie Krinner, Friederike Predoehl, Dinah Burfeind, Christian Vogl, Christian Vogl, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser   +10 more
doaj   +1 more source

Overloaded Adeno-Associated Virus as a Novel Gene Therapeutic Tool for Otoferlin-Related Deafness

Frontiers in Molecular Neuroscience, 2021
Hearing impairment is the most common sensory disorder in humans. So far, rehabilitation of profoundly deaf subjects relies on direct stimulation of the auditory nerve through cochlear implants.
Vladan Rankovic, Vladan Rankovic, Christian Vogl, Christian Vogl, Christian Vogl, Nele M. Dörje, Nele M. Dörje, Iman Bahader, Iman Bahader, Carlos J. Duque-Afonso, Carlos J. Duque-Afonso, Carlos J. Duque-Afonso, Anupriya Thirumalai, Thomas Weber, Kathrin Kusch, Kathrin Kusch, Nicola Strenzke, Nicola Strenzke, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser   +23 more
doaj   +1 more source

Hearing loss in mice with disruption of auditory epithelial patterning in the cochlea

Frontiers in Cell and Developmental Biology, 2022
In the cochlear auditory epithelia, sensory hair and supporting cells are arranged in a checkerboard-like mosaic pattern, which is conserved across a wide range of species.
Sayaka Katsunuma, Sayaka Katsunuma, Sayaka Katsunuma, Hideru Togashi, Hideru Togashi, Shuhei Kuno, Takeshi Fujita, Ken-Ichi Nibu   +7 more
doaj   +1 more source

Research Progress on the Mechanism of Cochlear Hair Cell Regeneration

Frontiers in Cellular Neuroscience, 2021
Mammalian inner ear hair cells do not have the ability to spontaneously regenerate, so their irreversible damage is the main cause of sensorineural hearing loss.
Shan Xu, Ning Yang
doaj   +1 more source

Survival of auditory hair cells [PDF]

Cell and Tissue Research, 2015
The inability of mammals to regenerate auditory hair cells creates a pressing need to understand the means of enhancing hair cell survival following insult or injury. Hair cells are easily damaged by noise exposure, by ototoxic medications and as a consequence of aging processes, all of which lead to progressive and permanent hearing impairment as hair
Michelle L. Seymour, Fred A. Pereira
openaire   +3 more sources

The developmental genetics of auditory hair cells [PDF]

Human Molecular Genetics, 2004
Loss of auditory hair cells (AHCs) is a major cause of human deafness. Considerable effort has been devoted to unraveling how these mechanotransducers of sound are specified, with a view to correcting hearing loss by gene or stem cell therapies. Recent work on signaling cascades, particularly lateral inhibition and planar cell polarity, has begun to ...
Michael Lovett, R. David Hawkins
openaire   +3 more sources