Results 1 to 10 of about 103,584 (208)

Molecular regulation of auditory hair cell death and approaches to protect sensory receptor cells and/or stimulate repair following acoustic trauma

Frontiers in Cellular Neuroscience, 2015
Loss of auditory sensory hair cells is the most common cause of hearing loss. This review addresses the signaling pathways that are involved in the programmed and necrotic cell death of auditory hair cells that occur in response to ototoxic and traumatic
Christine Dinh, Espe Bas, Thomas VAN DE WATER   +2 more
exaly   +4 more sources

Recent Advancements in the Regeneration of Auditory Hair Cells and Hearing Restoration

Frontiers in Molecular Neuroscience, 2017
Neurosensory responses of hearing and balance are mediated by receptors in specialized neuroepithelial sensory cells. Any disruption of the biochemical and molecular pathways that facilitate these responses can result in severe deficits, including ...
Adrien Eshraghi, Xue Zhong Liu, Thomas VAN DE WATER   +2 more
exaly   +2 more sources

Hair Cell Mechanotransduction Regulates Spontaneous Activity and Spiral Ganglion Subtype Specification in the Auditory System

Cell, 2018
SUMMARY Type I spiral ganglion neurons (SGNs) transmit sound information from cochlear hair cells to the CNS. Using transcriptome analysis of thousands of single neurons, we demonstrate that murine type I SGNs consist of subclasses that are defined by ...
Adam Palermo, Dwight Bergles, Ulrich Mueller   +2 more
exaly   +2 more sources

Inner Hair Cell Loss Disrupts Hearing and Cochlear Function Leading to Sensory Deprivation and Enhanced Central Auditory Gain

Frontiers in Neuroscience, 2017
There are three times as many outer hair cells (OHC) as inner hair cells (IHC), yet IHC transmit virtually all acoustic information to the brain as they synapse with 90–95% of type I auditory nerve fibers.
Benjamin Auerbach, Edward Lobarinas, Richard Salvi   +2 more
exaly   +2 more sources

Calcium action potentials in hair cells pattern auditory neuron activity before hearing onset

Nature Neuroscience, 2010
We found rat central auditory neurons to fire action potentials in a precise sequence of mini-bursts before the age of hearing onset. This stereotyped pattern was initiated by hair cells in the cochlea, which trigger brief bursts of action potentials in ...
Adrian Rodríguez-Contreras, Gérard Borst, Dwight Bergles   +2 more
exaly   +2 more sources

Eps8 Regulates Hair Bundle Length and Functional Maturation of Mammalian Auditory Hair Cells

PLoS Biology, 2011
Hair cells of the mammalian cochlea are specialized for the dynamic coding of sound stimuli. The transduction of sound waves into electrical signals depends upon mechanosensitive hair bundles that project from the cell's apical surface. Each stereocilium
V. Zampini, L. Rüttiger, Stuart L. Johnson, Christoph Franz, D. Furness, Jörg Waldhaus, Hao Xiong, C. Hackney, M. Holley, Nina Offenhauser, P. P. Di Fiore, M. Knipper, S. Masetto, W. Marcotti   +13 more
semanticscholar   +7 more sources

RIM-Binding Proteins Are Required for Normal Sound-Encoding at Afferent Inner Hair Cell Synapses

Frontiers in Molecular Neuroscience, 2021
The afferent synapses between inner hair cells (IHC) and spiral ganglion neurons are specialized to faithfully encode sound with sub-millisecond precision over prolonged periods of time.
Stefanie Krinner, Stefanie Krinner, Stefanie Krinner, Friederike Predoehl, Dinah Burfeind, Christian Vogl, Christian Vogl, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser   +10 more
doaj   +1 more source

Overloaded Adeno-Associated Virus as a Novel Gene Therapeutic Tool for Otoferlin-Related Deafness

Frontiers in Molecular Neuroscience, 2021
Hearing impairment is the most common sensory disorder in humans. So far, rehabilitation of profoundly deaf subjects relies on direct stimulation of the auditory nerve through cochlear implants.
Vladan Rankovic, Vladan Rankovic, Christian Vogl, Christian Vogl, Christian Vogl, Nele M. Dörje, Nele M. Dörje, Iman Bahader, Iman Bahader, Carlos J. Duque-Afonso, Carlos J. Duque-Afonso, Carlos J. Duque-Afonso, Anupriya Thirumalai, Thomas Weber, Kathrin Kusch, Kathrin Kusch, Nicola Strenzke, Nicola Strenzke, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser   +23 more
doaj   +1 more source

Hearing loss in mice with disruption of auditory epithelial patterning in the cochlea

Frontiers in Cell and Developmental Biology, 2022
In the cochlear auditory epithelia, sensory hair and supporting cells are arranged in a checkerboard-like mosaic pattern, which is conserved across a wide range of species.
Sayaka Katsunuma, Sayaka Katsunuma, Sayaka Katsunuma, Hideru Togashi, Hideru Togashi, Shuhei Kuno, Takeshi Fujita, Ken-Ichi Nibu   +7 more
doaj   +1 more source

Survival of auditory hair cells [PDF]

Cell and Tissue Research, 2015
The inability of mammals to regenerate auditory hair cells creates a pressing need to understand the means of enhancing hair cell survival following insult or injury. Hair cells are easily damaged by noise exposure, by ototoxic medications and as a consequence of aging processes, all of which lead to progressive and permanent hearing impairment as hair
Michelle L, Seymour, Fred A, Pereira
openaire   +2 more sources