Results 1 to 10 of about 91,097 (243)

Molecular Regulation of Auditory Hair Cell Death and Approaches to Protect Sensory Receptor Cells and/or Stimulate Repair Following Acoustic Trauma

Frontiers in Cellular Neuroscience, 2015
Loss of auditory sensory hair cells is the most common cause of hearing loss. This review addresses the signaling pathways that are involved in the programmed and necrotic cell death of auditory hair cells that occur in response to ototoxic and traumatic
Christine T DINH, Stefania eGONCALVES, Esperanza eBAS, Thomas R VAN DE WATER, Azel eZINE, Azel eZINE   +5 more
doaj   +2 more sources

The lhfpl5 Ohnologs lhfpl5a and lhfpl5b Are Required for Mechanotransduction in Distinct Populations of Sensory Hair Cells in Zebrafish

Frontiers in Molecular Neuroscience, 2020
Hair cells sense and transmit auditory, vestibular, and hydrodynamic information by converting mechanical stimuli into electrical signals. This process of mechano-electrical transduction (MET) requires a mechanically gated channel localized in the apical
Timothy Erickson, Timothy Erickson, Itallia V. Pacentine, Alexandra Venuto, Rachel Clemens, Teresa Nicolson   +5 more
doaj   +2 more sources

Pvalb8, a Type of Oncomodulin, Regulates Neuromast Development and Auditory Function in Zebrafish [PDF]

Cells
Congenital hearing loss, frequently resulting from defective hair cells, remains poorly understood due to the incomplete identification of key pathogenic genes. Oncomodulin (OCM) is a kind of calcium-binding protein (CaBP) that regulates diverse cellular
Guiyi Zhang, Qianqian Li, Ying Xu, Hanmeng Zhao, Chao Yang, Dong Liu, Jie Gong   +6 more
doaj   +2 more sources

Delayed structural maturation of inner hair cell ribbon synapses in a mouse model of fragile X syndrome [PDF]

Frontiers in Molecular Neuroscience
Clinical features of the fragile X syndrome (FXS) phenotype include intellectual disability, repetitive behaviors, social communication deficits, and, commonly, auditory hypersensitivity to acoustic stimuli.
M. Chojnacka, A. Skupien-Jaroszek, M. Dziembowska   +2 more
doaj   +2 more sources

Efferent control of hair cells mechanically coupled by artificial membranes [PDF]

Scientific Reports
The efferent system has been proposed to play a vital function in auditory and vestibular systems, by protecting the sensory hair cells from injury and preserving signal detection sensitivity.
Martín A. Toderi, Gabriela Muñoz-Hernandez, Justin Faber, Dolores Bozovic   +3 more
doaj   +2 more sources

RIM-Binding Proteins Are Required for Normal Sound-Encoding at Afferent Inner Hair Cell Synapses

Frontiers in Molecular Neuroscience, 2021
The afferent synapses between inner hair cells (IHC) and spiral ganglion neurons are specialized to faithfully encode sound with sub-millisecond precision over prolonged periods of time.
Stefanie Krinner, Stefanie Krinner, Stefanie Krinner, Friederike Predoehl, Dinah Burfeind, Christian Vogl, Christian Vogl, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser   +10 more
doaj   +1 more source

Overloaded Adeno-Associated Virus as a Novel Gene Therapeutic Tool for Otoferlin-Related Deafness

Frontiers in Molecular Neuroscience, 2021
Hearing impairment is the most common sensory disorder in humans. So far, rehabilitation of profoundly deaf subjects relies on direct stimulation of the auditory nerve through cochlear implants.
Vladan Rankovic, Vladan Rankovic, Christian Vogl, Christian Vogl, Christian Vogl, Nele M. Dörje, Nele M. Dörje, Iman Bahader, Iman Bahader, Carlos J. Duque-Afonso, Carlos J. Duque-Afonso, Carlos J. Duque-Afonso, Anupriya Thirumalai, Thomas Weber, Kathrin Kusch, Kathrin Kusch, Nicola Strenzke, Nicola Strenzke, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser   +23 more
doaj   +1 more source

PIN1 Protects Hair Cells and Auditory HEI-OC1 Cells against Senescence by Inhibiting the PI3K/Akt/mTOR Pathway

Oxidative Medicine and Cellular Longevity, 2021
A growing amount of evidence has confirmed the crucial role of the prolyl isomerase PIN1 in aging and age-related diseases. However, the mechanism of PIN1 in age-related hearing loss (ARHL) remains unclear.
Yanzhuo Zhang, Zhe Lv, Yudong Liu, H. Cao, Jianwang Yang, Baoshan Wang   +5 more
semanticscholar   +1 more source

Hearing loss in mice with disruption of auditory epithelial patterning in the cochlea

Frontiers in Cell and Developmental Biology, 2022
In the cochlear auditory epithelia, sensory hair and supporting cells are arranged in a checkerboard-like mosaic pattern, which is conserved across a wide range of species.
Sayaka Katsunuma, Sayaka Katsunuma, Sayaka Katsunuma, Hideru Togashi, Hideru Togashi, Shuhei Kuno, Takeshi Fujita, Ken-Ichi Nibu   +7 more
doaj   +1 more source

Research Progress on the Mechanism of Cochlear Hair Cell Regeneration

Frontiers in Cellular Neuroscience, 2021
Mammalian inner ear hair cells do not have the ability to spontaneously regenerate, so their irreversible damage is the main cause of sensorineural hearing loss.
Shan Xu, Ning Yang
doaj   +1 more source