Results 1 to 10 of about 105,366 (205)

Eps8 regulates hair bundle length and functional maturation of mammalian auditory hair cells [PDF]

PLoS Biology, 2011
Hair cells of the mammalian cochlea are specialized for the dynamic coding of sound stimuli. The transduction of sound waves into electrical signals depends upon mechanosensitive hair bundles that project from the cell's apical surface. Each stereocilium
V. Zampini, L. Rüttiger, Stuart L. Johnson, Christoph Franz, D. Furness, Jörg Waldhaus, Hao Xiong, C. Hackney, M. Holley, Nina Offenhauser, P. P. Di Fiore, M. Knipper, S. Masetto, W. Marcotti   +13 more
core   +8 more sources

The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells

EMBO Molecular Medicine, 2014
International audienceProtocadherin-15 (Pcdh15) is a component of the tip-links, the extracellular filaments that gate hair cell mechano-electrical transduction channels in the inner ear.
Bahloul, Amel, Makrelouf, Mohamed, Richard Goodyear, Muriel Holder, Petit, Christine, Michel, Vincent, Jean‐Pierre Hardelin, Hardelin, Jean-Pierre, Amel Bahloul, Guy Richardson, Pepermans, Elise, Holder, Muriel, Typhaine Dupont, Dupont, Typhaine, Elise Pepermans, Samia Abdi, Mohamed Makrelouf, Zenati, Akila, Marlin, Sandrine, Akila Zenati, Paul Avan, Gherbi, Souad, Vittot, Michel, Richardson, Guy, Sandrine Marlin, Abdi, Samia, Avan, Paul, Goodyear, Richard, Bonnet, Crystel, Souad Gherbi, Vincent Michel, Christine Petit, Crystel Bonnet   +32 more
core   +2 more sources

Recent Advancements in the Regeneration of Auditory Hair Cells and Hearing Restoration

Frontiers in Molecular Neuroscience, 2017
Neurosensory responses of hearing and balance are mediated by receptors in specialized neuroepithelial sensory cells. Any disruption of the biochemical and molecular pathways that facilitate these responses can result in severe deficits, including ...
Rahul Mittal, Desirée Nguyen, Amit P Patel   +2 more
exaly   +2 more sources

Hair Cell Mechanotransduction Regulates Spontaneous Activity and Spiral Ganglion Subtype Specification in the Auditory System

Cell, 2018
SUMMARY Type I spiral ganglion neurons (SGNs) transmit sound information from cochlear hair cells to the CNS. Using transcriptome analysis of thousands of single neurons, we demonstrate that murine type I SGNs consist of subclasses that are defined by ...
Shuohao Sun, Travis A Babola, Adam T Palermo   +2 more
exaly   +2 more sources

Autophagy protects auditory hair cells against neomycin-induced damage

Autophagy, 2017
Aminoglycosides are toxic to sensory hair cells (HCs). Macroautophagy/autophagy is an essential and highly conserved self-digestion pathway that plays important roles in the maintenance of cellular function and viability under stress.
Zuhong He, Yilai Shu, Yongze Liu
exaly   +2 more sources

Molecular regulation of auditory hair cell death and approaches to protect sensory receptor cells and/or stimulate repair following acoustic trauma

Frontiers in Cellular Neuroscience, 2015
Loss of auditory sensory hair cells (HCs) is the most common cause of hearing loss. This review addresses the signaling pathways that are involved in the programmed and necrotic cell death of auditory HCs that occur in response to ototoxic and traumatic ...
Christine T Dinh, Stefania Gonçalves, Esperanza Bas   +2 more
exaly   +2 more sources

Calcium action potentials in hair cells pattern auditory neuron activity before hearing onset

Nature Neuroscience, 2010
We found rat central auditory neurons to fire action potentials in a precise sequence of mini-bursts before the age of hearing onset. This stereotyped pattern was initiated by hair cells in the cochlea, which trigger brief bursts of action potentials in ...
Nicolas X Tritsch, Adrian Rodríguez-Contreras, J Gérard G Borst   +2 more
exaly   +2 more sources

Inner Hair Cell Loss Disrupts Hearing and Cochlear Function Leading to Sensory Deprivation and Enhanced Central Auditory Gain

Frontiers in Neuroscience, 2017
There are three times as many outer hair cells (OHC) as inner hair cells (IHC), yet IHC transmit virtually all acoustic information to the brain as they synapse with 90–95% of type I auditory nerve fibers.
Richard Salvi, Dalian Ding, Edward Lobarinas   +2 more
exaly   +2 more sources

1.3 channels in mouse auditory hair cells

Journal of Physiology, 2007
Sound coding at the auditory inner hair cell synapse requires graded changes in neurotransmitter release, triggered by sustained activation of presynaptic Ca(v)1.3 voltage-gated Ca2+ channels.
Meyer, Alexander C., Françoise Haeseleer, Guiying Cui, Irina Calin‐Jageman, Jakob Neef, Lee, Amy, Haeseleer, Francoise, Alexander C. Meyer, Cui, Guiying, Calin-Jageman, Irina E., Neef, Jakob, Amy Lee, Moser, Tobias, Tobias Moser   +13 more
core   +2 more sources

Survival of auditory hair cells [PDF]

Cell and Tissue Research, 2015
The inability of mammals to regenerate auditory hair cells creates a pressing need to understand the means of enhancing hair cell survival following insult or injury. Hair cells are easily damaged by noise exposure, by ototoxic medications and as a consequence of aging processes, all of which lead to progressive and permanent hearing impairment as hair
Michelle L, Seymour, Fred A, Pereira
openaire   +2 more sources