Results 1 to 10 of about 54,737 (229)

A Critical E-box in Barhl1 3′ Enhancer Is Essential for Auditory Hair Cell Differentiation

Cells, 2019
Barhl1, a mouse homologous gene of Drosophila BarH class homeobox genes, is highly expressed within the inner ear and crucial for the long-term maintenance of auditory hair cells that mediate hearing and balance, yet little is known about the molecular ...
Kun Hou, Hui Jiang, Md. Rezaul Karim, Chao Zhong, Zhouwen Xu, Lin Liu, Minxin Guan, Jianzhong Shao, Xiao Huang   +8 more
doaj   +1 more source

Vesicular glutamatergic transmission in noise-induced loss and repair of cochlear ribbon synapses [PDF]

, 2019
Noise-induced excitotoxicity is thought to depend on glutamate. However, the excitotoxic mechanisms are unknown, and the necessity of glutamate for synapse loss or regeneration is unclear. Despite absence of glutamatergic transmission from cochlear inner
Carlquist, Jason, Davis, Bethany, Fitzpatrick, James A.J., Gantz, Jay A, Hirose, Keiko, Kallogjeri, Dorina, Kim, Kyunghee X, Li, Song-Zhe, Ohlemiller, Kevin K, Payne, Shelby, Rutherford, Mark A, V-Ghaffari, Babak, Yang-Hood, Aizhen   +12 more
core   +1 more source

Evaluation of the Hair Cell Regeneration in Zebrafish Larvae by Measuring and Quantifying the Startle Responses

Neural Plasticity, 2017
The zebrafish has become an established model organism for the study of hearing and balance systems in the past two decades. The classical approach to examine hair cells is to use dye to conduct selective staining, which shows the number and morphology ...
Changquan Wang, Zhenmin Zhong, Peng Sun, Hanbing Zhong, Hongzhe Li, Fangyi Chen   +5 more
doaj   +1 more source

Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1

Scientific Reports, 2018
Recent work has demonstrated that transmembrane channel-like 1 protein (TMC1) is an essential component of the sensory transduction complex in hair cells of the inner ear.
Yukako Asai, Bifeng Pan, Carl Nist-Lund, Alice Galvin, Andrei N. Lukashkin, Victoria A. Lukashkina, Tianwen Chen, Wu Zhou, Hong Zhu, Ian J. Russell, Jeffrey R. Holt, Gwenaelle S. G. Géléoc   +11 more
doaj   +1 more source

The intensity JND comes from Poisson neural noise: Implications for image coding [PDF]

, 2000
While the problems of image coding and audio coding have frequently been assumed to have similarities, specific sets of relationships have remained vague.
Allen, Jont
core   +1 more source

Studies of intercellular Ca2+ signaling and gap-junction coupling in the developing cochlea of mouse models affected by congenital hearing loss [PDF]

, 2013
Connexin 26 (Cx26) and connexin 30 (Cx30) form gap junction channels that allow the intercellular diffusion of the Ca2+ mobilizing second messenger IP3.
Rodriguez Hernandez, Laura
core   +1 more source

The force-sensing GPCR LPHN2 is indispensable for normal auditory function

Cell Reports
Summary: The conversion of force sensation into electrical signals via mechano-electrical transduction (MET) is considered the key step in auditory perception. Here, we find that the G-protein-coupled receptor (GPCR) LPHN2/ADGRL2 is expressed at the tips
Shu-Hua Zhou, Ming-Wei Wang, Zhi-Chen Song, Zhao Yang, Kong-Kai Zhu, Xin Wen, Qi-Yue Zhang, Ying Guan, Jia-Rui Gao, Xiao-Hui Wang, Ya-Qi Wang, Wen-Wen Liu, Lei Xu, Wei Xiong, Ren-Jie Chai, Chuan Wang, Zhi-Gang Xu, Xiao Yu, Jin-Peng Sun   +18 more
doaj   +1 more source

Endolymphatic hydrops and cochlear synaptopathy after noise exposure are distinct sequelae of hair cell stereociliary bundle trauma

Scientific Reports
Endolymphatic hydrops, increased endolymphatic fluid within the cochlea, is the key pathologic finding in patients with Meniere’s disease, a disease of episodic vertigo, fluctuating hearing loss, tinnitus, and aural fullness.
Michelle L. Fong, Connie B. Paik, Patricia M. Quiñones, Clayton B. Walker, Michael J. Serafino, Dorothy W. Pan, Eduardo Martinez, Juemei Wang, Grady W. Phillips, Brian E. Applegate, Michael Anne Gratton, John S. Oghalai   +11 more
doaj   +1 more source

Therapeutic potential of stem cells in auditory hair cell repair

Journal of Stem Cells and Regenerative Medicine, 2009
The prevalence of acquired hearing loss is very high. About 10% of the total population and more than one third of the population over 65 years suffer from debilitating hearing loss.
Ryuji Hata
doaj  

Genetic and Environmental Factors Shaping Hearing Loss: Xenobiotics, Mechanisms and Translational Perspectives. [PDF]

J Xenobiot
Esteves F, Caria H.
europepmc   +1 more source