Hair cells, auditory - Open Access .click

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Therapeutic potential of stem cells in auditory hair cell repair

Journal of Stem Cells and Regenerative Medicine, 2009
The prevalence of acquired hearing loss is very high. About 10% of the total population and more than one third of the population over 65 years suffer from debilitating hearing loss.
Ryuji Hata
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Spiking Pattern of the Mouse Developing Inner Hair Cells Is Mostly Invariant Along the Tonotopic Axis

Frontiers in Cellular Neuroscience, 2018
During development, the sensory cells of the cochlea, the inner hair cells (IHCs), fire spontaneous calcium action potentials. This activity at the pre-hearing stage allows the IHCs to autonomously excite the auditory nerve fibers and hence, represents ...
Anne-Gabrielle Harrus +5 more
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It takes two

eLife, 2015
Two forms of an unconventional myosin motor protein have separate functions in the growth and maintenance of hair bundles in auditory hair cells.
Teresa Nicolson
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Pvalb8, a Type of Oncomodulin, Regulates Neuromast Development and Auditory Function in Zebrafish

Cells
Congenital hearing loss, frequently resulting from defective hair cells, remains poorly understood due to the incomplete identification of key pathogenic genes. Oncomodulin (OCM) is a kind of calcium-binding protein (CaBP) that regulates diverse cellular
Guiyi Zhang +6 more
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GPR156 is required in sensory hair cells for proper auditory and vestibular function

Scientific Reports
Proper orientation of the apical cytoskeleton in auditory and vestibular hair cells is essential for their sensory function. A recently identified regulator of hair cell orientation is the G protein-coupled receptor GPR156, which signals through ...
Amandine Jarysta +4 more
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A Critical E-box in Barhl1 3′ Enhancer Is Essential for Auditory Hair Cell Differentiation

Cells, 2019
Barhl1, a mouse homologous gene of Drosophila BarH class homeobox genes, is highly expressed within the inner ear and crucial for the long-term maintenance of auditory hair cells that mediate hearing and balance, yet little is known about the molecular ...
Kun Hou +8 more
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Evaluation of the Hair Cell Regeneration in Zebrafish Larvae by Measuring and Quantifying the Startle Responses

Neural Plasticity, 2017
The zebrafish has become an established model organism for the study of hearing and balance systems in the past two decades. The classical approach to examine hair cells is to use dye to conduct selective staining, which shows the number and morphology ...
Changquan Wang +5 more
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Efferent control of hair cells mechanically coupled by artificial membranes

Scientific Reports
The efferent system has been proposed to play a vital function in auditory and vestibular systems, by protecting the sensory hair cells from injury and preserving signal detection sensitivity.
Martín A. Toderi +3 more
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The force-sensing GPCR LPHN2 is indispensable for normal auditory function

Cell Reports
Summary: The conversion of force sensation into electrical signals via mechano-electrical transduction (MET) is considered the key step in auditory perception. Here, we find that the G-protein-coupled receptor (GPCR) LPHN2/ADGRL2 is expressed at the tips
Shu-Hua Zhou +18 more
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Endolymphatic hydrops and cochlear synaptopathy after noise exposure are distinct sequelae of hair cell stereociliary bundle trauma

Scientific Reports
Endolymphatic hydrops, increased endolymphatic fluid within the cochlea, is the key pathologic finding in patients with Meniere’s disease, a disease of episodic vertigo, fluctuating hearing loss, tinnitus, and aural fullness.
Michelle L. Fong +11 more
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medicine
cochlea
hair cell

hair cells
inner ear
hearing

regeneration
auditory