Results 1 to 10 of about 55,191 (266)

Severe hearing loss and outer hair cell death in homozygous Foxo3 knockout mice after moderate noise exposure [PDF]

Scientific Reports, 2017
Noise induced hearing loss (NIHL) is a disease that affects millions of Americans. Identifying genetic pathways that influence recovery from noise exposure is an important step forward in understanding NIHL.
Felicia Gilels, Stephen T. Paquette, Holly J. Beaulac, Anwen Bullen, Patricia M. White   +4 more
doaj   +2 more sources

GPR156 is required in sensory hair cells for proper auditory and vestibular function [PDF]

Scientific Reports
Proper orientation of the apical cytoskeleton in auditory and vestibular hair cells is essential for their sensory function. A recently identified regulator of hair cell orientation is the G protein-coupled receptor GPR156, which signals through ...
Amandine Jarysta, Brandie Morris Verdone, Elli I. Hartig, Kathleen E. Cullen, Basile Tarchini   +4 more
doaj   +2 more sources

Pvalb8, a Type of Oncomodulin, Regulates Neuromast Development and Auditory Function in Zebrafish [PDF]

Cells
Congenital hearing loss, frequently resulting from defective hair cells, remains poorly understood due to the incomplete identification of key pathogenic genes. Oncomodulin (OCM) is a kind of calcium-binding protein (CaBP) that regulates diverse cellular
Guiyi Zhang, Qianqian Li, Ying Xu, Hanmeng Zhao, Chao Yang, Dong Liu, Jie Gong   +6 more
doaj   +2 more sources

Delayed structural maturation of inner hair cell ribbon synapses in a mouse model of fragile X syndrome [PDF]

Frontiers in Molecular Neuroscience
Clinical features of the fragile X syndrome (FXS) phenotype include intellectual disability, repetitive behaviors, social communication deficits, and, commonly, auditory hypersensitivity to acoustic stimuli.
M. Chojnacka, A. Skupien-Jaroszek, M. Dziembowska   +2 more
doaj   +2 more sources

Efferent control of hair cells mechanically coupled by artificial membranes [PDF]

Scientific Reports
The efferent system has been proposed to play a vital function in auditory and vestibular systems, by protecting the sensory hair cells from injury and preserving signal detection sensitivity.
Martín A. Toderi, Gabriela Muñoz-Hernandez, Justin Faber, Dolores Bozovic   +3 more
doaj   +2 more sources

RIM-Binding Proteins Are Required for Normal Sound-Encoding at Afferent Inner Hair Cell Synapses

Frontiers in Molecular Neuroscience, 2021
The afferent synapses between inner hair cells (IHC) and spiral ganglion neurons are specialized to faithfully encode sound with sub-millisecond precision over prolonged periods of time.
Stefanie Krinner, Stefanie Krinner, Stefanie Krinner, Friederike Predoehl, Dinah Burfeind, Christian Vogl, Christian Vogl, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser   +10 more
doaj   +1 more source

Overloaded Adeno-Associated Virus as a Novel Gene Therapeutic Tool for Otoferlin-Related Deafness

Frontiers in Molecular Neuroscience, 2021
Hearing impairment is the most common sensory disorder in humans. So far, rehabilitation of profoundly deaf subjects relies on direct stimulation of the auditory nerve through cochlear implants.
Vladan Rankovic, Vladan Rankovic, Christian Vogl, Christian Vogl, Christian Vogl, Nele M. Dörje, Nele M. Dörje, Iman Bahader, Iman Bahader, Carlos J. Duque-Afonso, Carlos J. Duque-Afonso, Carlos J. Duque-Afonso, Anupriya Thirumalai, Thomas Weber, Kathrin Kusch, Kathrin Kusch, Nicola Strenzke, Nicola Strenzke, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser   +23 more
doaj   +1 more source

Hearing loss in mice with disruption of auditory epithelial patterning in the cochlea

Frontiers in Cell and Developmental Biology, 2022
In the cochlear auditory epithelia, sensory hair and supporting cells are arranged in a checkerboard-like mosaic pattern, which is conserved across a wide range of species.
Sayaka Katsunuma, Sayaka Katsunuma, Sayaka Katsunuma, Hideru Togashi, Hideru Togashi, Shuhei Kuno, Takeshi Fujita, Ken-Ichi Nibu   +7 more
doaj   +1 more source

Survival of auditory hair cells [PDF]

Cell and Tissue Research, 2015
The inability of mammals to regenerate auditory hair cells creates a pressing need to understand the means of enhancing hair cell survival following insult or injury. Hair cells are easily damaged by noise exposure, by ototoxic medications and as a consequence of aging processes, all of which lead to progressive and permanent hearing impairment as hair
Michelle L, Seymour, Fred A, Pereira
openaire   +2 more sources

Research Progress on the Mechanism of Cochlear Hair Cell Regeneration

Frontiers in Cellular Neuroscience, 2021
Mammalian inner ear hair cells do not have the ability to spontaneously regenerate, so their irreversible damage is the main cause of sensorineural hearing loss.
Shan Xu, Ning Yang
doaj   +1 more source