Results 1 to 10 of about 53,617 (156)

Severe hearing loss and outer hair cell death in homozygous Foxo3 knockout mice after moderate noise exposure [PDF]

Scientific Reports, 2017
Noise induced hearing loss (NIHL) is a disease that affects millions of Americans. Identifying genetic pathways that influence recovery from noise exposure is an important step forward in understanding NIHL.
Felicia Gilels, Stephen T. Paquette, Holly J. Beaulac, Anwen Bullen, Patricia M. White   +4 more
doaj   +2 more sources

Delayed structural maturation of inner hair cell ribbon synapses in a mouse model of fragile X syndrome [PDF]

Frontiers in Molecular Neuroscience
Clinical features of the fragile X syndrome (FXS) phenotype include intellectual disability, repetitive behaviors, social communication deficits, and, commonly, auditory hypersensitivity to acoustic stimuli.
M. Chojnacka, A. Skupien-Jaroszek, M. Dziembowska   +2 more
doaj   +2 more sources

Pvalb8, a Type of Oncomodulin, Regulates Neuromast Development and Auditory Function in Zebrafish [PDF]

Cells
Congenital hearing loss, frequently resulting from defective hair cells, remains poorly understood due to the incomplete identification of key pathogenic genes. Oncomodulin (OCM) is a kind of calcium-binding protein (CaBP) that regulates diverse cellular
Guiyi Zhang, Qianqian Li, Ying Xu, Hanmeng Zhao, Chao Yang, Dong Liu, Jie Gong   +6 more
doaj   +2 more sources

Kolliker’s Organ and Its Functional Role in the Development of Corti’s Organ and Auditory Systems [PDF]

Audiology Research
Background: Kölliker’s organ (KO), a transient structure in the cochlea, plays a critical role in the auditory maturation of mammals, particularly during embryonic and early postnatal development.
Valeria Caragli, Valerio M. Di Pasquale Fiasca, Elisabetta Genovese, Alessandro Martini   +3 more
doaj   +2 more sources

RIM-Binding Proteins Are Required for Normal Sound-Encoding at Afferent Inner Hair Cell Synapses

Frontiers in Molecular Neuroscience, 2021
The afferent synapses between inner hair cells (IHC) and spiral ganglion neurons are specialized to faithfully encode sound with sub-millisecond precision over prolonged periods of time.
Stefanie Krinner, Stefanie Krinner, Stefanie Krinner, Friederike Predoehl, Dinah Burfeind, Christian Vogl, Christian Vogl, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser   +10 more
doaj   +1 more source

Overloaded Adeno-Associated Virus as a Novel Gene Therapeutic Tool for Otoferlin-Related Deafness

Frontiers in Molecular Neuroscience, 2021
Hearing impairment is the most common sensory disorder in humans. So far, rehabilitation of profoundly deaf subjects relies on direct stimulation of the auditory nerve through cochlear implants.
Vladan Rankovic, Vladan Rankovic, Christian Vogl, Christian Vogl, Christian Vogl, Nele M. Dörje, Nele M. Dörje, Iman Bahader, Iman Bahader, Carlos J. Duque-Afonso, Carlos J. Duque-Afonso, Carlos J. Duque-Afonso, Anupriya Thirumalai, Thomas Weber, Kathrin Kusch, Kathrin Kusch, Nicola Strenzke, Nicola Strenzke, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser   +23 more
doaj   +1 more source

Hearing loss in mice with disruption of auditory epithelial patterning in the cochlea

Frontiers in Cell and Developmental Biology, 2022
In the cochlear auditory epithelia, sensory hair and supporting cells are arranged in a checkerboard-like mosaic pattern, which is conserved across a wide range of species.
Sayaka Katsunuma, Sayaka Katsunuma, Sayaka Katsunuma, Hideru Togashi, Hideru Togashi, Shuhei Kuno, Takeshi Fujita, Ken-Ichi Nibu   +7 more
doaj   +1 more source

Research Progress on the Mechanism of Cochlear Hair Cell Regeneration

Frontiers in Cellular Neuroscience, 2021
Mammalian inner ear hair cells do not have the ability to spontaneously regenerate, so their irreversible damage is the main cause of sensorineural hearing loss.
Shan Xu, Ning Yang
doaj   +1 more source

Hearing Recovery Induced by DNA Demethylation in a Chemically Deafened Adult Mouse Model

Frontiers in Cellular Neuroscience, 2022
Functional hair cell regeneration in the adult mammalian inner ear remains challenging. This study aimed to study the function of new hair cells induced by a DNA demethylating agent 5-azacytidine.
Xin Deng, Zhengqing Hu, Zhengqing Hu
doaj   +1 more source

Conserved and Divergent Principles of Planar Polarity Revealed by Hair Cell Development and Function

Frontiers in Neuroscience, 2021
Planar polarity describes the organization and orientation of polarized cells or cellular structures within the plane of an epithelium. The sensory receptor hair cells of the vertebrate inner ear have been recognized as a preeminent vertebrate model ...
Michael R. Deans, Michael R. Deans
doaj   +1 more source