Results 41 to 50 of about 22,677 (167)

Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells. [PDF]

PLoS ONE, 2014
To determine whether activated Notch can promote a supporting cell fate during sensory cell differentiation in the inner ear.An activated form of the Notch1 receptor (NICD) was expressed in early differentiating hair cells using a Gfi1-Cre mouse allele ...
Grace Savoy-Burke, Felicia A Gilels, Wei Pan, Diana Pratt, Jianwen Que, Lin Gan, Patricia M White, Amy E Kiernan   +7 more
doaj   +1 more source

PIN1 protects auditory hair cells from senescence via autophagy

PeerJ, 2022
Background Age-related hearing loss is an increasing sensorineural hearing loss. But the pathogenesis of ARHL has not been clarified. Herein, we studied the role and significance of PIN1 in regulating autophagy activity in senescence HEI-OC1cells and HCs. Methods and Results
Zhe Lv, Yanzhuo Zhang, Huan Cao, Qingjuan Liu, Xiaojuan Feng, Huan Yin, BaoShan Wang   +6 more
openaire   +3 more sources

Insights into the regulation of hearing regeneration

Frontiers in Audiology and Otology
Our perception of sound is mediated by sound-sensitive hair cells in the inner ear, located in a specialized neuro-epithelium that transmits information to the auditory cortex via the auditory pathway.
Lama Khalaily, Karen B. Avraham
doaj   +1 more source

Specific Influences of Early Acoustic Environments on Cochlear Hair Cells in Postnatal Mice

Neural Plasticity, 2018
The auditory function develops and matures after birth in many mammalian species. After hearing onset, environmental sounds exert profound and long-term effects on auditory functions.
Aoshuang Chang, Peng Chen, Shasha Guo, Nana Xu, Wenlu Pan, Hongzheng Zhang, Cuixian Li, Jie Tang   +7 more
doaj   +1 more source

Dexamethasone uptake in the murine organ of Corti with transtympanic versus systemic administration

Journal of Otolaryngology - Head and Neck Surgery, 2013
Objective To investigate glucocorticoid uptake in auditory hair cells following transtympanic versus systemic administration of dexamethasone. Study design Controlled experimental study. Setting Translational science experimental laboratory.
Amandeep S Grewal, Julian M Nedzelski, Joseph M Chen, Vincent YW Lin   +3 more
doaj   +1 more source

The lhfpl5 Ohnologs lhfpl5a and lhfpl5b Are Required for Mechanotransduction in Distinct Populations of Sensory Hair Cells in Zebrafish

Frontiers in Molecular Neuroscience, 2020
Hair cells sense and transmit auditory, vestibular, and hydrodynamic information by converting mechanical stimuli into electrical signals. This process of mechano-electrical transduction (MET) requires a mechanically gated channel localized in the apical
Timothy Erickson, Timothy Erickson, Itallia V. Pacentine, Alexandra Venuto, Rachel Clemens, Teresa Nicolson   +5 more
doaj   +1 more source

Regenerated Synapses Between Postnatal Hair Cells and Auditory Neurons [PDF]

Journal of the Association for Research in Otolaryngology, 2013
Regeneration of synaptic connections between hair cells and spiral ganglion neurons would be required to restore hearing after neural loss. Here we demonstrate by immunohistochemistry the appearance of afferent-like cochlear synapses in vitro after co-culture of de-afferented organ of Corti with spiral ganglion neurons from newborn mice.
Mingjie, Tong, Aurore, Brugeaud, Albert S B, Edge   +2 more
openaire   +2 more sources

C1ql1 is expressed in adult outer hair cells of the cochlea in a tonotopic gradient.

PLoS ONE, 2021
Hearing depends on the transduction of sounds into neural signals by the inner hair cells of the cochlea. Cochleae also have outer hair cells with unique electromotile properties that increase auditory sensitivity, but they are particularly susceptible ...
Joyshree Biswas, Robert S Pijewski, Rohit Makol, Tania G Miramontes, Brianna L Thompson, Lyndsay C Kresic, Alice L Burghard, Douglas L Oliver, David C Martinelli   +8 more
doaj   +1 more source

Artificial induction of Sox21 regulates sensory cell formation in the embryonic chicken inner ear.

PLoS ONE, 2012
During embryonic development, hair cells and support cells in the sensory epithelia of the inner ear derive from progenitors that express Sox2, a member of the SoxB1 family of transcription factors.
Stephen D Freeman, Nicolas Daudet
doaj   +1 more source

Molecular mechanisms governing development of the hindbrain choroid plexus and auditory projection: A validation of the seminal observations of Wilhelm His

IBRO Neuroscience Reports, 2022
Studies by His from 1868 to 1904 delineated the critical role of the dorsal roof plate in the development of the hindbrain choroid plexus, and of the rhombic lips in the development of hindbrain auditory centers.
Joel C. Glover, Bernd Fritzsch
doaj   +1 more source