Results 71 to 80 of about 89,289 (243)

NOX2 Contributes to High‐Frequency Outer Hair Cell Vulnerability in the Cochlea

Advanced Science, EarlyView.
This study first identifies NOX2 as a differentially expressed gene related to oxidative damage in the apical and basal turns through single‐cell RNA sequencing. NOX2 gene knockout mitigates OHCs damage caused by neomycin and noise and enhances Nrf2 expression and nuclear translocation.
Meihao Qi, Zejun Gao, Yang Qiu, Renfeng Wang, Keyong Tian, Bo Yue, Xinyu Zhang, Peng Zhang, Ziqi Wu, Qingwen Zhu, Zhenzhen Liu, Zhuoyao Ma, Xueying Zhou, Yu Han, Jun Chen, Jianhua Qiu, DingJun Zha   +16 more
wiley   +1 more source

Viscoelastic relaxation in the membrane of the auditory outer hair cell

Biophysical Journal, 1996
The outer hair cell (OHC) in the mammalian ear has a unique membrane potential-dependent motility, which is considered to be important for frequency discrimination (tuning). The OHC motile mechanism is located at the cell membrane and is strongly influenced by its passive mechanical properties.
Kuni H. Iwasa, David Ehrenstein
openaire   +3 more sources

LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing

Advanced Science, EarlyView.
This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang, Yuehui Xi, Qiaojun Fang, Sai Shi, Fei Wang, Fuyu Xian, Zhongyang Zhang, Yuxin Yang, Xishuo Jin, Xiaomin Wang, Chen Cao, Hailin Zhang, Nikita Gamper, Zhigang Xu, Haitao Shen, Ping Lv   +15 more
wiley   +1 more source

Delayed structural maturation of inner hair cell ribbon synapses in a mouse model of fragile X syndrome

Frontiers in Molecular Neuroscience
Clinical features of the fragile X syndrome (FXS) phenotype include intellectual disability, repetitive behaviors, social communication deficits, and, commonly, auditory hypersensitivity to acoustic stimuli.
M. Chojnacka, A. Skupien-Jaroszek, M. Dziembowska   +2 more
doaj   +1 more source

Severe hearing loss and outer hair cell death in homozygous Foxo3 knockout mice after moderate noise exposure

Scientific Reports, 2017
Noise induced hearing loss (NIHL) is a disease that affects millions of Americans. Identifying genetic pathways that influence recovery from noise exposure is an important step forward in understanding NIHL.
Felicia Gilels, Stephen T. Paquette, Holly J. Beaulac, Anwen Bullen, Patricia M. White   +4 more
doaj   +1 more source

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation

Nature Communications, 2018
In the adult auditory organ, mechanoelectrical transducer (MET) channels are essential for transducing acoustic stimuli into electrical signals. In the absence of incoming sound, a fraction of the MET channels on top of the sensory hair cells are open ...
Laura F. Corns, Stuart L. Johnson, Terri Roberts, K. M. Ranatunga, Aenea C. Hendry, F. Ceriani, S. Safieddine, K. Steel, A. Forge, C. Petit, D. Furness, C. Kros, W. Marcotti   +12 more
semanticscholar   +1 more source

Brain‐Wide Spatiotemporally Distinct Traveling Waves Drive Anxiety‐Like Behaviors in Mice

Advanced Science, EarlyView.
J.Liu et al. reveal the complete propagation dynamics of cortical traveling waves, from local circuitry initiation to long‐range propagation, and identify their functional relevance in modulating anxiety‐like behaviors and underlying cellular neuroplasticity in mice.
Jiaming Liu, Jia‐Wen Mo, Xunda Wang, Yinuo Ma, Shile Tian, Qi Wang, Peng‐Li Kong, Ziqi An, Li Ding, Jing Ren, Cheng‐Lin Lu, Chuanjun Tong, Ed X. Wu, Qiu‐gen Hu, Xiong Cao, Yanqiu Feng   +15 more
wiley   +1 more source

Stem-cell therapy for hearing loss: are we there yet?

Brazilian Journal of Otorhinolaryngology, 2019
Introduction: Mammalian hair cells and auditory neurons do not show regenerative capacity. Hence, damage to these cell types is permanent and leads to hearing loss. However, there is no treatment that re-establishes auditory function.
Luiz Gustavo Dufner-Almeida, Dayane Bernardino da Cruz, Regina Célia Mingroni Netto, Ana Carla Batissoco, Jeanne Oiticica, Rodrigo Salazar-Silva   +5 more
doaj   +1 more source

Conductive Nanocomposite Hydrogels for Neural Tissue Engineering: A Systematic Scoping Review of Recent Trends

Advanced Science, EarlyView.
This systematic scoping review explores conductive nanocomposite hydrogels for neural tissue engineering(NTE), focusing on composition, cellular interactions, and neural differentiation capabilities. The review synthesizes data from 125 studies, examining important features including commonly used materials, cell types, and differentiation strategies ...
Mohammad Moghaddasi, Busra Oktay, Ayse Betul Bingol, Reyhan Yanikoglu, Meryem Muslu, Ibrahim T Ozbolat, Cem Bulent Ustundag   +6 more
wiley   +1 more source

Gata3 is required for the functional maturation of inner hair cells and their innervation in the mouse cochlea

Journal of Physiology, 2019
The physiological maturation of auditory hair cells and their innervation requires precise temporal and spatial control of cell differentiation. The transcription factor gata3 is essential for the earliest stages of auditory system development and for ...
Tanaya Bardhan, J. Jeng, Marco Waldmann, F. Ceriani, Stuart L. Johnson, J. Olt, L. Rüttiger, W. Marcotti, M. Holley   +8 more
semanticscholar   +1 more source