Results 71 to 80 of about 119,470 (327)

Electrical tuning and transduction in short hair cells of the chicken auditory papilla.

Journal of Neurophysiology, 2013
The avian auditory papilla contains two classes of sensory receptor, tall hair cells (THCs) and short hair cells (SHCs), the latter analogous to mammalian outer hair cells with large efferent but sparse afferent innervation.
Xiaodong Tan, M. Beurg, C. Hackney, S. Mahendrasingam, R. Fettiplace   +4 more
semanticscholar   +1 more source

The very large G-protein coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles [PDF]

, 2006
Sensory hair bundles in the inner ear are composed of stereocilia that can be interconnected by a variety of different link types, including tip links, horizontal top connectors, shaft connectors, and ankle links.
Birch, David G, Goodyear, Richard J, Holt, Jeffrey R, Legan, P Kevin, Locke, Kirsten G, McGee, JoAnn, McMillan, D Randy, Richardson, Guy P, Stauffer, Eric A, Walsh, Edward J, White, Perrin C   +10 more
core   +1 more source

C1ql1 is expressed in adult outer hair cells of the cochlea in a tonotopic gradient.

PLoS ONE, 2021
Hearing depends on the transduction of sounds into neural signals by the inner hair cells of the cochlea. Cochleae also have outer hair cells with unique electromotile properties that increase auditory sensitivity, but they are particularly susceptible ...
Joyshree Biswas, Robert S Pijewski, Rohit Makol, Tania G Miramontes, Brianna L Thompson, Lyndsay C Kresic, Alice L Burghard, Douglas L Oliver, David C Martinelli   +8 more
doaj   +1 more source

Molecular Remodeling of Tip Links Underlies Mechanosensory Regeneration in Auditory Hair Cells

PLoS Biology, 2013
Backscatter scanning electron microscopy and conventional whole cell patch-clamp experiments reveal a two-step mechanism for the regeneration of tip links, the crucial element of mechanotransduction machinery in the hair cells of the inner ear.
Artur A. Indzhykulian, R. Stepanyan, Anastasiia Nelina, K. Spinelli, Zubair M. Ahmed, I. Belyantseva, T. Friedman, Peter G. Barr-Gillespie, G. Frolenkov   +8 more
semanticscholar   +1 more source

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

Advanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong, You Zhou, Qingxiu Li, Wenyu Zhao, Sunyingyue Geng, Hangfei Li, Yan‐Bing Leng, Shirui Zhu, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Ye Zhou, Su‐Ting Han   +12 more
wiley   +1 more source

Imaging Stereocilia Links in Live Auditory Hair Cells [PDF]

Biophysical Journal, 2012
We previously imaged stereocilia links in glutaraldehyde-fixed mammalian auditory hair cells using hopping probe scanning ion conductance microcopy (HPSICM, Novak et al. Nat Methods, 2009). Due to the complex three-dimensional structure of the stereocilia bundle, achieving high-resolution images required a considerable amount of time (∼44 min/bundle ...
Artur A. Indzhykulian, Ghanshyam P. Sinha, A. Catalina Vélez-Ortega, Gregory I. Frolenkov   +3 more
openaire   +2 more sources

Approaches of auditory hair cells induction from stem cells [PDF]

, 2017
Hair cells are the sensory epithelial cells of both the auditory and the vestibular systems in the inner ear of all vertebrates. Auditory hair cells are located in the organ of corti on a thin layer of basement membrane in the cochlea of the inner ear ...
Ahmady Roozbahany, Navid, Khoshsirat, Shahrokh, Niknazar, Somayeh   +2 more
core   +2 more sources

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source

Resolution of subcomponents of synaptic release from post-synaptic currents in rat hair-cell/auditory-nerve fiber synapses

bioRxiv, 2020
The synapse between inner hair cells and auditory nerve fiber dendrites shows large EPSCs, which are either monophasic or multiphasic. Multiquantal or uniquantal flickering release have been proposed to underlie the unusual multiphasic waveforms.
E. Young, Jingjing Sherry Wu, Mamiko Niwa, E. Glowatzki   +3 more
semanticscholar   +1 more source

Cellular studies of auditory hair cell regeneration in birds [PDF]

Proceedings of the National Academy of Sciences, 2000
A decade ago it was discovered that mature birds are able to regenerate hair cells, the receptors for auditory perception. This surprising finding generated hope in the field of auditory neuroscience that new hair cells someday may be coaxed to form in another class of warm-blooded vertebrates, mammals.
Jennifer S. Stone, Edwin W. Rubel
openaire   +3 more sources