Results 161 to 170 of about 5,094 (206)

Astrocytes in Neurodegeneration: Spatial States, Crosstalk, and Emerging Therapies. [PDF]

Mol Neurobiol
Steger L, Rothhammer V, Zunke F.
europepmc   +1 more source

Molecular dynamics simulation of GJC2 mutants reveal pathogenic mechanisms of PMLD1 and SPG44. [PDF]

J Gen Physiol
Gong D, Orthmann-Murphy JL, Kumar D, Dungan GD, El-Hattab AW, Schiess N, Luo YL, Freidin MM, Abrams CK.   +8 more
europepmc   +1 more source

Connecting the dots on connexin function. [PDF]

J Gen Physiol
Short B.
europepmc   +1 more source

Endothelial TRPV4-Cx43 signalling complex regulates vasomotor tone in resistance arteries. [PDF]

J Physiol
Burboa PC, Gaete PS, Shu P, Araujo PA, Beuve AV, Durán WN, Contreras JE, Lillo MA.   +7 more
europepmc   +1 more source

The contractile system as a negative regulator of the connexin 43 hemichannel

Biology of the Cell, 2012
The molecular mechanisms underlying the regulation of gap junction (GJ) channels based on the 43-kDa connexin isoform (Cx43) have been studied extensively. GJ channels are formed by the docking of opposed hemichannels in adjacent cells.
Luc Leybaert, Geert Bultynck
exaly   +2 more sources

Structural determinants underlying permeant discrimination of the Cx43 hemichannel [PDF]

Journal of Biological Chemistry, 2019
Connexin (Cx) gap junction channels comprise two hemichannels in neighboring cells, and their permeability is well-described, but permeabilities of the single Cx hemichannel remain largely unresolved.
Francesco Zonta, Brian Skriver Nielsen, Thomas Litman   +2 more
exaly   +2 more sources

Non-Additive Effects of Delayed Connexin Hemichannel Blockade and Hypothermia after Cerebral Ischemia in Near-Term Fetal Sheep

Journal of Cerebral Blood Flow and Metabolism, 2015
Hypothermia is partially neuroprotective after neonatal hypoxic-ischemic encephalopathy. Blockade of connexin hemichannels can improve recovery of brain activity and cell survival after ischemia in near-term fetal sheep.
Laura Bennet, Guido Wassink, Joanne Davidson   +2 more
exaly   +2 more sources

Mechanical Stretch Activates TRPV4 and Hemichannel Responses in the Nonpigmented Ciliary Epithelium

International Journal of Molecular Sciences, 2023
Previously, we reported a mechanosensitive ion channel, TRPV4, along with functional connexin hemichannels on the basolateral surface of the ocular nonpigmented ciliary epithelium (NPE).
Mohammad Shahidullah, Nick Delamere
exaly   +2 more sources

Gap junction- and hemichannel-independent actions of connexins [PDF]

Biochimica Et Biophysica Acta - Biomembranes, 2005
Connexins have been known to be the protein building blocks of gap junctions and mediate cell–cell communication. In contrast to the conventional dogma, recent evidence suggests that in addition to forming gap junction channels, connexins possess gap ...
Jean Jiang, Sumin Gu
exaly   +2 more sources

Collagen I Modifies Connexin-43 Hemichannel Activity via Integrin α2β1 Binding in TGFβ1-Evoked Renal Tubular Epithelial Cells

International Journal of Molecular Sciences, 2021
Chronic Kidney Disease (CKD) is associated with sustained inflammation and progressive fibrosis, changes that have been linked to altered connexin hemichannel-mediated release of adenosine triphosphate (ATP).
Joe Potter, Claire Hills, Gareth Price   +2 more
exaly   +2 more sources