Results 181 to 190 of about 4,743 (216)

Hemichannels in Cerebral Ischemia

Current Molecular Medicine, 2009
Hemichannels are transmembrane channels that represent the functional subunits of gap junctions. Each hemichannel is composed of a connexin or pannexin hexamer and, after being transported to the membrane, remains unpaired until it is incorporated in a gap junction. Several studies have already provided evidence that gap junction-mediated intercellular
Panagiotis, Bargiotas, Hannah, Monyer, Markus, Schwaninger   +2 more
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Gap junctional hemichannels in the heart

Acta Physiologica Scandinavica, 2003
AbstractUpon contacting each other, cells form gap junctions, in which each cell contributes half of the channel linking their cytoplasms, enabling them to share their metabolome up to a molecular weight of 1000. Each hemichannel (or connexon) is randomly inserted into the plasma membrane and then migrates to the site of cell‐to‐cell contact before ...
S, John, D, Cesario, J N, Weiss
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Connexin hemichannel inhibitors with a focus on aminoglycosides

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2021
Connexins are membrane proteins involved directly in cell-to-cell communication through the formation of gap-junctional channels. These channels result from the head-to-head docking of two hemichannels, one from each of two adjacent cells. Undocked hemichannels are also present at the plasma membrane where they mediate the efflux of molecules that ...
Cristina M, Natha, Varun, Vemulapalli, Mariana C, Fiori, Cheng-Wei T, Chang, Guillermo A, Altenberg   +4 more
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Connexin43 Hemichannel Targeting With TAT-Gap19 Alleviates Radiation-Induced Endothelial Cell Damage [PDF]

Frontiers in Pharmacology, 2020
: Background Emerging evidence indicates an excess risk of late occurring cardiovascular diseases, especially atherosclerosis, after thoracic cancer radiotherapy.
Dornatien Chuo Anang, Luc Leybaert, Elke Decrock   +2 more
exaly   +3 more sources

Hemichannel-Mediated Inhibition in the Outer Retina

Science, 2001
An essential feature of the first synapse in the retina is a negative feedback pathway from horizontal cells to cones. Here we show that at this synapse, connexin26 forms hemichannels on horizontal cell dendrites near the glutamate release site of the cones. Blocking these hemichannels hyperpolarizes horizontal cells, modulates the Ca
Kamermans, M., Fahrenfort, I., Schultz, K., Janssen-Bienhold, U., Sjoerdsma, T., Weiler, R.   +5 more
openaire   +2 more sources

Biophysical characterization of zebrafish connexin35 hemichannels

American Journal of Physiology-Cell Physiology, 2004
A subset of connexins can form unopposed hemichannels in expression systems, providing an opportunity for comparison of hemichannel gating properties with those of intact gap junction channels. Zebrafish connexin35 (Cx35) is a member of the Cx35/Cx36 subgroup of connexins highly expressed in the retina and brain.
Virginijus, Valiunas, Rickie, Mui, Elizabeth, McLachlan, Gunnar, Valdimarsson, Peter R, Brink, Thomas W, White   +5 more
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Hemichannels: New pathways for gliotransmitter release

Neuroscience, 2015
Growing evidence suggests that glial cells express virtually all known types of neurotransmitter receptors, enabling them to sense neuronal activity and microenvironment changes by responding locally via the Ca(2+)-dependent release of bioactive molecules, known as "gliotransmitters".
Montero, T.D., Orellana Roca, Juan Andrés   +1 more
openaire   +3 more sources

Gap junction and hemichannel functions in osteocytes

Bone, 2013
Cell-to-cell and cell-to-matrix communication in bone cells mediated by gap junctions and hemichannels, respectively, maintains bone homeostasis. Gap junctional communication between cells permits the passage of small molecules including calcium and cyclic AMP. This cell-to-cell communication occurs between bone cells including osteoblasts, osteoclasts
Alayna E, Loiselle, Jean X, Jiang, Henry J, Donahue   +2 more
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Functional connexin “hemichannels”: A critical appraisal

Glia, 2006
Abstract“Hemichannels” are defined as the halves of gap junction channels (also termed connexons) that are contributed by one cell; “hemichannels” are considered to be functional if they are open in nonjunctional membranes in the absence of pairing with partners from adjacent cells.
David C, Spray, Zu-Cheng, Ye, Bruce R, Ransom   +2 more
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Connexin Hemichannel Inhibition and Human Genodermatoses

Journal of Investigative Dermatology
Pathogenic variants in genes encoding connexins that cause skin diseases, such as keratitis-ichthyosis-deafness (KID) syndrome and hidrotic ectodermal dysplasia (HED) or Clouston syndrome, display increased hemichannel activity. Mechanistic insights derived from biophysical studies of the variant connexins support the hypothesis that inhibition of the ...
Fabio Mammano, Amy S. Paller, Thomas W. White   +2 more
openaire   +2 more sources