Are Insulin and Metformin Really Protective on Amyotrophic Lateral Sclerosis by Blocking the Astrocytic Cx43 Channel? [PDF]
Chronic Dis Transl MedFinsterer J.
europepmc +1 more source
Viral Infection and Connexin Dysfunction in the Heart. [PDF]
Curr Cardiol RepPhillips CM, Smyth JW.
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Boldine as a neuroprotective agent against motor neuron degeneration in models of amyotrophic lateral sclerosis. [PDF]
Front Cell NeurosciToro CA +10 more
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Lens Biomechanics and Mechanotransduction Signaling: Dual Pillars of Age-Related Cataract Pathogenesis. [PDF]
Invest Ophthalmol Vis SciLi H, Hao S, Yu Y, Yao K, Fu Q.
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Structural determinants underlying permeant discrimination of the Cx43 hemichannel [PDF]
Journal of Biological Chemistry, 2019 Connexin (Cx) gap junction channels comprise two hemichannels in neighboring cells, and their permeability is well-described, but permeabilities of the single Cx hemichannel remain largely unresolved.
Francesco Zonta +2 more
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The contractile system as a negative regulator of the connexin 43 hemichannel [PDF]
Biology of the Cell, 2012 The molecular mechanisms underlying the regulation of gap junction (GJ) channels based on the 43-kDa connexin isoform (Cx43) have been studied extensively. GJ channels are formed by the docking of opposed hemichannels in adjacent cells.
Luc Leybaert, Geert Bultynck
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Collagen I Modifies Connexin-43 Hemichannel Activity via Integrin α2β1 Binding in TGFβ1-Evoked Renal Tubular Epithelial Cells [PDF]
International Journal of Molecular Sciences, 2021 Chronic Kidney Disease (CKD) is associated with sustained inflammation and progressive fibrosis, changes that have been linked to altered connexin hemichannel-mediated release of adenosine triphosphate (ATP).
Joe Potter +2 more
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Gap junction- and hemichannel-independent actions of connexins [PDF]
Biochimica Et Biophysica Acta - Biomembranes, 2005 Connexins have been known to be the protein building blocks of gap junctions and mediate cell–cell communication. In contrast to the conventional dogma, recent evidence suggests that in addition to forming gap junction channels, connexins possess gap ...
Jean Jiang, Sumin Gu
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Mechanical Stretch Activates TRPV4 and Hemichannel Responses in the Nonpigmented Ciliary Epithelium [PDF]
International Journal of Molecular Sciences, 2023 Previously, we reported a mechanosensitive ion channel, TRPV4, along with functional connexin hemichannels on the basolateral surface of the ocular nonpigmented ciliary epithelium (NPE).
Mohammad Shahidullah, Nick Delamere
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Connexin hemichannel and pannexin channel electrophysiology: How do they differ? [PDF]
FEBS Letters, 2014 Connexin hemichannels are postulated to form a cell permeabilization pore for the uptake of fluorescent dyes and release of cellular ATP. Connexin hemichannel activity is enhanced by low external [Ca2+]o, membrane depolarization, metabolic inhibition ...
Richard Veenstra, Dakshesh Patel
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