Results 171 to 180 of about 5,094 (206)

Hemichannels in Cerebral Ischemia

Current Molecular Medicine, 2009
Hemichannels are transmembrane channels that represent the functional subunits of gap junctions. Each hemichannel is composed of a connexin or pannexin hexamer and, after being transported to the membrane, remains unpaired until it is incorporated in a gap junction. Several studies have already provided evidence that gap junction-mediated intercellular
Panagiotis, Bargiotas, Hannah, Monyer, Markus, Schwaninger   +2 more
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Gap junctional hemichannels in the heart

Acta Physiologica Scandinavica, 2003
AbstractUpon contacting each other, cells form gap junctions, in which each cell contributes half of the channel linking their cytoplasms, enabling them to share their metabolome up to a molecular weight of 1000. Each hemichannel (or connexon) is randomly inserted into the plasma membrane and then migrates to the site of cell‐to‐cell contact before ...
S, John, D, Cesario, J N, Weiss
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Hemichannel-Mediated Inhibition in the Outer Retina

Science, 2001
An essential feature of the first synapse in the retina is a negative feedback pathway from horizontal cells to cones. Here we show that at this synapse, connexin26 forms hemichannels on horizontal cell dendrites near the glutamate release site of the cones. Blocking these hemichannels hyperpolarizes horizontal cells, modulates the Ca
Kamermans, M., Fahrenfort, I., Schultz, K., Janssen-Bienhold, U., Sjoerdsma, T., Weiler, R.   +5 more
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Biophysical characterization of zebrafish connexin35 hemichannels

American Journal of Physiology-Cell Physiology, 2004
A subset of connexins can form unopposed hemichannels in expression systems, providing an opportunity for comparison of hemichannel gating properties with those of intact gap junction channels. Zebrafish connexin35 (Cx35) is a member of the Cx35/Cx36 subgroup of connexins highly expressed in the retina and brain.
Virginijus, Valiunas, Rickie, Mui, Elizabeth, McLachlan, Gunnar, Valdimarsson, Peter R, Brink, Thomas W, White   +5 more
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Functional connexin “hemichannels”: A critical appraisal

Glia, 2006
Abstract“Hemichannels” are defined as the halves of gap junction channels (also termed connexons) that are contributed by one cell; “hemichannels” are considered to be functional if they are open in nonjunctional membranes in the absence of pairing with partners from adjacent cells.
David C, Spray, Zu-Cheng, Ye, Bruce R, Ransom   +2 more
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Gap junction and hemichannel functions in osteocytes

Bone, 2013
Cell-to-cell and cell-to-matrix communication in bone cells mediated by gap junctions and hemichannels, respectively, maintains bone homeostasis. Gap junctional communication between cells permits the passage of small molecules including calcium and cyclic AMP. This cell-to-cell communication occurs between bone cells including osteoblasts, osteoclasts
Alayna E, Loiselle, Jean X, Jiang, Henry J, Donahue   +2 more
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Severe neuropathy with leaky connexin32 hemichannels

Annals of Neurology, 2005
AbstractX‐linked Charcot‐Marie‐Tooth disease is one of a set of diseases caused by mutations in gap junction proteins called connexins. We identified a connexin32 missense mutation (F235C) in a girl with unusually severe neuropathy. The localization and trafficking of the mutant protein in cell culture was normal, but electrophysiological studies ...
Grace S Lin, Liang, Marta, de Miguel, Juan M, Gómez-Hernández, Jonathan D, Glass, Steven S, Scherer, Mark, Mintz, Luis C, Barrio, Kenneth H, Fischbeck   +7 more
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Connexin Hemichannel Inhibition and Human Genodermatoses

Journal of Investigative Dermatology
Pathogenic variants in genes encoding connexins that cause skin diseases, such as keratitis-ichthyosis-deafness (KID) syndrome and hidrotic ectodermal dysplasia (HED) or Clouston syndrome, display increased hemichannel activity. Mechanistic insights derived from biophysical studies of the variant connexins support the hypothesis that inhibition of the ...
Fabio Mammano, Amy S. Paller, Thomas W. White   +2 more
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Glial Cx43 hemichannels and neuronal Panx1 hemichannels and P2X7 receptors orchestrate presynaptic homeostatic plasticity

Cellular Signalling
The emerging role of glial cells in modulating neuronal excitability and synaptic strength is a growing field in neuroscience. In recent years, a pivotal role of gliotransmission in homeostatic presynaptic plasticity has been highlighted and glial-derived ATP arises as a key contributor.
Alberto, Rafael, Marina, Tizzoni, Cristian, Justet, Andrea, Cairus, Verónica, Abudara, Nathalia, Vitureira   +5 more
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Mechanisms Underlying Connexin Hemichannel Activation in Disease

International Journal of Molecular Sciences, 2021
Mathieu Vinken, Timo de Groof, Devoogdt Nick   +2 more
exaly