Results 121 to 130 of about 15,174 (240)

Neuronal involvement in muscular atrophy

Frontiers in Cellular Neuroscience, 2014
The innervation of skeletal myofibers exerts a crucial influence on the maintenance of muscle tone and normal operation. Consequently, denervated myofibers manifest atrophy, which is preceded by an increase in sarcolemma permeability.
Bruno Alejandro Cisterna, Christopher eCardozo, Christopher eCardozo, Juan C Saez, Juan C Saez   +4 more
doaj   +1 more source

Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in mice [PDF]

, 2017
While gap junctions mediate intercellular communication and support liver homeostasis, connexin hemichannels are preferentially opened by pathological stimuli, including inflammation and oxidative stress.
Cogliati, Bruno, Crespo Yanguas, Sara, da Silva, Tereza Cristina, de Castro, Inar Alves, Decrock, Elke, Felisbino, Daniele Aparecida, Govoni, Veronica Mollica, Leclercq, Isabelle, Leybaert, Luc, Lima, Andressa, Maes, Michaël, Nogueira, Marina Sayuri, Pereira, Isabel Veloso Alves, Rodrigues, Robim Marcelino, Vinken, Mathieu, Willebrords, Joost   +15 more
core   +2 more sources

De Novo Gene Transcription of Connexin Mediates Cytoplasmic Fluid Exchange and Flocking Transitions in Physiological and Cancerous Epithelial Systems

Advanced Science, Volume 13, Issue 6, 30 January 2026.
EGF‐induced de novo transcription of connexins Cx26 and Cx31 promotes flocking behavior that fluidizes epithelia and enables coordinated collective migration. Connexin‐driven cytoplasmic exchange mechanistically links growth‐factor signaling to invasive dynamics.
Hind Abdo, Leonardo Barzaghi, Yuan Shen, Edoardo Bellini, Emanuele Martini, Serena Magni, Sara Barozzi, Fabrizio Orsenigo, Dario Parazzoli, Galina V. Beznoussenko, Jasmin Di Franco, Fabian Krautgasser, Jasmin Kaivola, Mario Cinquanta, Alessandro Lazzarin, Sara Sigismund, Johanna Ivaska, Roberto Cerbino, Giorgio Scita   +18 more
wiley   +1 more source

Inhibition of astroglial hemichannels prevents synaptic transmission decline during spreading depression

Biological Research
Background Spreading depression (SD) is an intriguing phenomenon characterized by massive slow brain depolarizations that affect neurons and glial cells.
Juan E. Tichauer, Matías Lira, Waldo Cerpa, Juan A. Orellana, Juan C. Sáez, Maximiliano Rovegno   +5 more
doaj   +1 more source

GLIAL HEMICHANNELS: A NEW ROUTE FOR CHEMICAL COMMUNICATION IN BRAIN [PDF]

, 2008
The extracellular neurochemistry determines normal brain function and the faith of neurons after insults such as stroke. This thesis concerns the effect of extracellular events related to intense neuronal stimulation and stroke, i.e.
Stridh, Malin
core   +1 more source

Electrical Synapses Contribute to Sleep‐Dependent Declarative Memory Retention

European Journal of Neuroscience, Volume 63, Issue 2, January 2026.
Blocking electrical synapses (gap junctions) in healthy humans by mefloquine impaired the sleep‐dependent retention of verbal declarative memory and improved sensorimotor memory consolidation irrespective of sleep. Mefloquine also disrupted the coupling of sleep spindles to EEG slow oscillations in humans but did not affect hippocampal sharp‐wave ...
Gordon B. Feld, Niels Niethard, Jianfeng Liu, Sandra Gebhardt, Lisa Kleist, Kerstin Brugger, Andreas Fritsche, Jan Born, Hong‐Viet V. Ngo, Manfred Hallschmid   +9 more
wiley   +1 more source

From Cells to Animals: Connexin43 Suppression Enhances Autophagic Flux to Restore Odontogenesis in Inflamed Dental Pulp

International Endodontic Journal, Volume 59, Issue 1, Page 134-152, January 2026.
ABSTRACT Aim Under certain conditions, infection‐induced inflammation may activate reparative processes to form a hard tissue barrier against microbial invasion. Autophagy participates in odontogenic differentiation during inflammation in vitro, but its role in pulp repair remains unclear.
Peiling Hu, Yingqing Chen, Ping Long, Anni Zhang, Xiaorong Lan, Yuanpei He, Guangwen Li, Shiting Li   +7 more
wiley   +1 more source

The p.Cys169Tyr variant of connexin 26 is not a polymorphism [PDF]

, 2015
Mutations in the GJB2 gene, which encodes the gap junction protein connexin 26 (Cx26), are the primary cause of hereditary prelingual hearing impairment. Here, the p.Cys169Tyr missense mutation of Cx26 (Cx26C169Y), previously classified as a polymorphism,
Abdulhadi, Khalid, Alkowari, Moza, Badii, Ramin, Buratto, Damiano, Crispino, Giulia, Gasparini, Paolo, Girotto, Giorgia, Mammano, Fabio, Morgan, Anna, Zonta, Francesco   +9 more
core   +1 more source

Treatment of Epidermal Pathology in a Pediatric Patient With Keratitis–Ichthyosis–Deafness (KID) Syndrome With Topical Mefenamic Acid

Pediatric Dermatology, Volume 43, Issue 1, Page 145-148, January/February 2026.
ABSTRACT Keratitis–ichthyosis–deafness (KID) syndrome is a rare genetic condition typically presenting at birth with ichthyosiform erythroderma and bilateral hearing loss and later progressing to diffuse keratodermatous plaques with scaling. The condition is associated with mutations in the GJB2 gene, which lead to aberrant activation of connexin ...
Radhika Gupta, Alisa Ho, Lars Brichta, Albert C. Yan   +3 more
wiley   +1 more source

Dye-uptake Experiment through Connexin Hemichannels

Bio-Protocol, 2014
Connexins (Cxs) are integral membrane proteins of vertebrates that associate to form hexameric transmembrane channels, named hemichannels. Twenty-one Cx types have been described, which are named according to their molecular weight.
Andrea Puhar, Philippe Sansonetti
doaj   +1 more source