Results 131 to 140 of about 15,174 (240)

Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock [PDF]

, 2019
Upon intravenous injection of tumour necrosis factor (TNF) in mice, a systemic inflammatory response syndrome (SIRS) is initiated, characterized by an acute cytokine storm and induction of vascular hyperpermeability.
Czekaj, Aleksandra, De Smet, Maarten, Declercq, Wim, Decrock, Elke, Delvaeye, Tinneke, Gonçalves, Amanda, Krysko, Dmitri, Lemeire, Kelly, Leybaert, Luc, Vandenabeele, Peter, Vandenbroucke, Roosmarijn, Verwaerde, Stijn   +11 more
core   +2 more sources

The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease

Journal of Tropical Medicine, Volume 2026, Issue 1, 2026.
Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease (NTD) that can lead to severe cardiac complications, including chronic Chagas cardiomyopathy. While NTDs are caused by a variety of pathogens—such as protozoa, bacteria, viruses, and helminths, Chagas disease remains underexplored, particularly regarding host immune responses.
Caroline de Souza Ferreira Pereira, Robson Xavier Faria, Wei Wang   +2 more
wiley   +1 more source

Paracrine signaling through plasma membrane hemichannels

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2013
Plasma membrane hemichannels composed of connexin (Cx) proteins are essential components of gap junction channels but accumulating evidence suggests functions of hemichannels beyond the communication provided by junctional channels. Hemichannels not incorporated into gap junctions, called unapposed hemichannels, can open in response to a variety of ...
Wang, Nan, De Bock, Marijke, Decrock, Elke, Bol, Melissa, Gadicherla, Ashish, Vinken, Mathieu, Rogiers, Vera, Bukauskas, Felix, Bultynck, Geert, Leybaert, Luc   +9 more
openaire   +3 more sources

Modulation of Cx46 hemichannels by nitric oxide

American Journal of Physiology-Cell Physiology, 2009
Gap-junction hemichannels are composed of six protein subunits (connexins). Undocked hemichannels contribute to physiological autocrine/paracrine cell signaling, including release of signaling molecules, cell-volume regulation, and glucose uptake.
Retamal, Mauricio A., Yin, ShengYong, Altenberg, Guillermo A., Reuss, Luis   +3 more
openaire   +5 more sources

Motifs in the permeation pathway of connexin channels mediate Ca2+ and voltage sensing.

Frontiers in Physiology, 2014
Connexin channels mediate electrical coupling, intercellular molecular signaling and extracellular release of signaling molecules. Connexin proteins assemble intracellularly as hexamers to form plasma membrane hemichannels.
Andrew L. Harris, Jorge E. Contreras
doaj   +1 more source

Connexins and pannexins in liver damage [PDF]

, 2016
Connexins and pannexins are key players in the control of cellular communication and thus in the maintenance of tissue homeostasis. Inherent to this function these proteins are frequently involved in pathological processes.
Cogliati, Bruno, Crespo Yanguas, Sara, da Silva, Tereza Cristina, Maes, Michaël, Veloso Alves Pereira, Isabel, Vinken, Mathieu, Willebrords, Joost, Zaidan Dagli, Maria Lucia   +7 more
core   +1 more source

Connexin-based gap junction hemichannels: Gating mechanisms

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2005
Connexins (Cxs) form hemichannels and gap junction channels. Each gap junction channel is composed of two hemichannels, also termed connexons, one from each of the coupled cells. Hemichannels are hexamers assembled in the ER, the Golgi, or a post Golgi compartment. They are transported to the cell surface in vesicles and inserted by vesicle fusion, and
Saez, JC, Retamal, MA, Basilio, D, Bukauskas, FF, Bennett, MVL   +4 more
openaire   +5 more sources

Antidepressants impact connexin 43 channel functions in astrocytes

Frontiers in Cellular Neuroscience, 2016
Glial cells, and in particular astrocytes, are crucial to maintain neuronal microenvironment by regulating energy metabolism, neurotransmitter uptake, gliotransmission and synaptic development.
Tiffany eJeanson, Tiffany eJeanson, Audrey ePondaven, Pascal eEzan, Franck eMouthon, Mathieu eCharveriat, Christian eGiaume   +6 more
doaj   +1 more source

Immunohistochemistry using an antibody to unphosphorylated connexin 43 to identify human myometrial interstitial cells [PDF]

, 2008
Background Myometrial smooth myocytes contract as a result of electrical signalling via a process called excitation-contraction coupling. This process is understood in great detail at the cellular level but the generation and coordination of electrical ...
Graham Hutchings, Thomas Gevaert, Jan Deprest, Tania Roskams, Alfons Van Lommel, Bernd Nilius, Dirk De Ridder   +6 more
core   +2 more sources

Electrophysiology of Single and Aggregate Cx43 Hemichannels

PLoS ONE, 2012
Connexin43 (Cx43) is the most ubiquitous gap junction protein in the human body and is essential for cell-to-cell communication in a variety of organs and organ systems. As a result, Cx43 is responsible for mediating both electrical and chemical signals, passing dissolved solutes and small signaling molecules between cells in a coordinated fashion ...
Cole Brokamp, Jacob Todd, Carlo Montemagno, David Wendell   +3 more
openaire   +3 more sources