Results 121 to 130 of about 81,640 (295)

Glycosaminoglycans and Glycosaminoglycan Mimetics in Cancer and Inflammation [PDF]

, 2019
Glycosaminoglycans (GAGs) are a class of biomolecules expressed virtually on all mammalian cells and usually covalently attached to proteins, forming proteoglycans.
Morla, Shravan
core   +1 more source

From secretome analysis to immunology: chitosan induces major alterations in the activation of dendritic cells via a TLR4-dependent mechanism [PDF]

, 2009
Dendritic cells are known to be activated by a wide range of microbial products, leading to cytokine production and increased levels of membrane markers such as major histocompatibility complex class II molecules.
Arora, Behrens, Bellocchio, Berthier, Bittencourt, Chang, Chevallet, Chevallet, Chieppa, Curtsinger, de Saint-Vis, Dillon, Elliott, Faure, Gallucci, Gharahdaghi, Goetz, Johnson, Jørgensen, Kawai, Kennedy, Levitz, Luche, Maldonado-López, Murray, Owhashi, Peng, Perkins, Porporatto, Rabilloud, Rabilloud, Rabilloud, Richert, Romani, Seong, Shibata, Tada, Termeer, Underhill, Verhasselt, Wang, Yang, Young   +42 more
core   +5 more sources

Ontogeny of RSPO1, FOXL2, and RUNX1 during ovarian differentiation in the marsupial tammar wallaby

Developmental Dynamics, EarlyView.
Abstract Background RSPO1 and FOXL2 are female sex‐determining genes involved in the differentiation and organization of the ovary in some eutherian mammals. Mutations or loss of function of these genes are associated with partial to full sex reversal in mice, humans, and goats.
Monika R. Paranjpe, Yu Chen, Geoff Shaw, Marilyn B. Renfree   +3 more
wiley   +1 more source

Coxsackievirus A16 utilizes cell surface heparan sulfate glycosaminoglycans as its attachment receptor

Emerging Microbes and Infections, 2017
Coxsackievirus A16 (CVA16) is one of the major pathogens responsible for hand, foot and mouth disease, which affects more than two million children in the Asian-Pacific region annually.
Xueyang Zhang, Jinping Shi, Xiaohua Ye, Zhiqiang Ku, Chao Zhang, Qingwei Liu, Zhong Huang   +6 more
doaj   +1 more source

The heparanome—The enigma of encoding and decoding heparan sulfate sulfation

Journal of Biotechnology, 2007
Heparan sulfate (HS) is a cell surface carbohydrate polymer modified with sulfate moieties whose highly ordered composition is central to directing specific cell signaling events. The ability of the cell to generate these information rich glycans with such specificity has opened up a new field of "heparanomics" which seeks to understand the systems ...
Lamanna, William C., Kalus, Ina, Padva, Michael, Baldwin, Rebecca J., Merry, Catherine L. R., Dierks, Thomas   +5 more
openaire   +5 more sources

Strain-dependent porcine circovirus type 2 (PCV2) entry and replication in T-lymphoblasts [PDF]

, 2019
Porcine circovirus type 2 (PCV2) is the etiological agent of PCV2-associated diseases (PCVAD). PCV2 targets lymphoblasts, and pigs suffering from PCVAD display lymphocyte depletion in lymphoid tissues. PCV2 infection of lymphoblasts has not been studied.
Nauwynck, Hans, Van Renne, Nicolaas, Wei, Ruifang   +2 more
core   +1 more source

Bioactive polysaccharides and their potential health benefits in reducing the risks of metabolic syndrome: A review

Food Biomacromolecules, EarlyView.
Abstract Metabolic syndrome (MetS) is a complex noncommunicable condition characterized by central obesity, insulin resistance, hyperlipidemia, hypertension, and hyperglycemia. Epidemiological evidence shows that MetS affects a third of the global population; however, due to its complex pathogenesis and limited drug therapy options, the increasing ...
Josiah Owuor Oyalo, Evelyne Nkirote Gikundi, Mercy Adhiambo Ndiege, Kevin Omondi Aduol   +3 more
wiley   +1 more source

Role of Heparan Sulfate 2-O-Sulfotransferase in Prostate Cancer Cell Proliferation, Invasion, and Growth Factor Signaling

Prostate Cancer, 2011
Heparan-sulfate proteoglycans (HSPGs) are required for maximal growth factor signaling in prostate cancer progression. The degree of sulfate modification on the covalently attached heparan sulfate (HS) chains is one of the determining factors of growth ...
Brent W. Ferguson, Sumana Datta
doaj   +1 more source

Introduction to the Molecules Special Edition Entitled ‘Heparan Sulfate and Heparin: Challenges and Controversies’: Some Outstanding Questions in Heparan Sulfate and Heparin Research

Molecules, 2019
The scope of this article is to provide a brief general introduction to heparan sulfate (HS) and heparin, and attempt to identify some of the central challenges regarding research into the chemistry and biology of glycosaminoglycans (GAGs), some of which
Edwin A Yates, John T Gallagher, Marco Guerrini   +2 more
doaj   +1 more source

Investigating the bHLH transcription factor TSARL1 as marker and regulator of saponin biosynthesis in Chenopodium quinoa

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Quinoa (Chenopodium quinoa) is valued for its nutritional benefits and resilience to abiotic stresses. However, its commercial use is limited by bitter‐tasting saponins on the seeds, necessitating resource‐intensive removal processes.
Marius Kollmar, Katharina B. Böndel, Lukas John, Stefan Arold, Karl Schmid, David Jarvis, Sandra M Schmöckel, Sophie L Otterbach   +7 more
wiley   +1 more source