Results 171 to 180 of about 475,440 (346)

Chemoenzymatic synthesis of heparan sulfate and heparin.

open access: yesNatural product reports (Print), 2014
Heparan sulfate is a polysaccharide that plays essential physiological functions in the animal kingdom. Heparin, a highly sulfated form of heparan sulfate, is a widely prescribed anticoagulant drug worldwide. The heparan sulfate and heparin isolated from
Jian Liu, R. J. Linhardt
semanticscholar   +1 more source

The Role of Heparanase and Sulfatases in the Modification of Heparan Sulfate Proteoglycans within the Tumor Microenvironment and Opportunities for Novel Cancer Therapeutics

open access: yesFrontiers in Oncology, 2014
Heparan sulfate proteoglycans (HSPGs) are an integral and dynamic part of normal tissue architecture at the cell surface and within the extracellular matrix.
E. Hammond   +3 more
semanticscholar   +1 more source

Investigating the bHLH transcription factor TSARL1 as marker and regulator of saponin biosynthesis in Chenopodium quinoa

open access: yesJournal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Quinoa (Chenopodium quinoa) is valued for its nutritional benefits and resilience to abiotic stresses. However, its commercial use is limited by bitter‐tasting saponins on the seeds, necessitating resource‐intensive removal processes.
Marius Kollmar   +7 more
wiley   +1 more source

Protein glycosylation in lung cancer from a mass spectrometry perspective

open access: yesMass Spectrometry Reviews, EarlyView.
Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi   +2 more
wiley   +1 more source

Genomics and Histopathology in Interstitial Cystitis/Bladder Pain Syndrome

open access: yesNeurourology and Urodynamics, EarlyView.
ABSTRACT Aims In April of 2025, a Global Consensus meeting on IC/BPS was held in Winston‐Salem, NC. The goal of this meeting was to establish global consensus in diagnostic criteria, phenotyping, treatment outcome assessment, and possible etiopathology in interstitial cystitis/bladder pain syndrome (IC/BPS).
Hannah Ruetten   +4 more
wiley   +1 more source

Mitochondrial transfer as a novel therapeutic approach in ischemic stroke treatment: Current challenges and future perspectives

open access: yesNeuroprotection, EarlyView.
Cerebral ischemia is a serious neurological disease that mainly leads to pathological changes such as mitochondrial dysfunction, oxidative stress and iron death. Mitochondria play a key role in the regulation of cellular energy metabolism and oxidative stress, and their damage can lead to mitochondrial damage, reduced adenosine triphosphate production,
Shuchen Meng   +9 more
wiley   +1 more source

Concentration‐Based Analysis of Metal‐Induced Tau Fibrillar versus non‐fibrillar Aggregation: Implications for Neurotoxicity in Alzheimer's Disease

open access: yesChemistryOpen, EarlyView.
Tau protein aggregation and fibrillation have been examined in relationship to three metal ions in this study. The research was conducted to see the effects of Zn2+, Cu2+ and Fe3+ ions at different concentrations on tau′s conformation, cytotoxicity in SH‐SY5Y cells, and free thiol levels.
Mahzad Irandoust   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy