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Virus adaptation to heparan sulfate comes with capsid stability tradeoff. [PDF]
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The heparitin sulfates (heparan sulfates)
Carbohydrate Research, 1973Heparitin sulfate has been isolated from several sources, namely: a commercial lung polysaccharide preparation, beef lung, beef aorta, human amyloid liver, human intestine, and urine of a patient with mucopolysaccharidosis. The polysaccharides isolated were extensively purified, fractionated, and characterized.
A, Linker, P, Hovingh
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Heparan Sulfate Proteoglycans in Diabetes
Seminars in Thrombosis and Hemostasis, 2021AbstractDiabetes is a complex disorder responsible for the mortality and morbidity of millions of individuals worldwide. Although many approaches have been used to understand and treat diabetes, the role of proteoglycans, in particular heparan sulfate proteoglycans (HSPGs), has only recently received attention.
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1999
Abstract Heparan sulfate proteoglycans (HSPGs)1 are highly charged macromolecules consisting of different core proteins with covalently linked heparan sulfate chains (HS) of varying monosaccharide sequence. These molecules are involved in a multitude of biologic processes including regulation of mesoderm induction, extension of neurites,
Nicholas W Shworak, Robert D Rosenberg
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Abstract Heparan sulfate proteoglycans (HSPGs)1 are highly charged macromolecules consisting of different core proteins with covalently linked heparan sulfate chains (HS) of varying monosaccharide sequence. These molecules are involved in a multitude of biologic processes including regulation of mesoderm induction, extension of neurites,
Nicholas W Shworak, Robert D Rosenberg
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Antithrombin, heparin, and heparan sulfate
Critical Care Medicine, 2002To review the experimental and clinical evidence that antithrombin has multiple mechanisms for both its anticoagulant and anti-inflammatory properties. The interaction between antithrombin and specific polysulfated, acidic oligosaccharide moieties found on heparin and related proteoglycan molecules within the circulation and on endothelial surfaces ...
Steven M, Opal +3 more
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Biological Activities of Heparan Sulfate
2014Heparan sulfate was isolated from two bivalve mollusks such as Tridacna maxima and Perna viridis. The isolated heparin was quantified in crude as well as purified samples and they were estimated as 2.72 and 2.2g/kg (crude) and 260 and 248 mg/g (purified) in T. maxima and P. viridis, respectively.
Muthuvel, Arumugam, Sadhasivam, Giji
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Heparan Sulfate Proteoglycans in Amyloidosis
2010Amyloidosis is a generic term for a group of diseases characterized by deposits in different organ systems of insoluble materials composed mainly of distinct fibrillar proteins named amyloid. Besides amyloid, heparan sulfate proteoglycan (HSPG), is commonly found in most amyloid deposits, suggesting that HS/HSPG may be functionally involved in the ...
Xiao, Zhang, Jin-Ping, Li
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