Results 81 to 90 of about 465,990 (261)

Bioengineering Strategies for Treating Neointimal Hyperplasia in Peripheral Vasculature: Innovations and Challenges

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
This review highlights emerging bioengineering strategies for treating neointimal hyperplasia in the peripheral vasculature, focusing on approaches that promote re‐endothelialization, modulate smooth muscle cell phenotype, reduce inflammation, mitigate oxidative stress, and optimize biomechanical compliance.
Nikita Wilson John   +5 more
wiley   +1 more source

Mutations in the E2 Glycoprotein of Venezuelan Equine Encephalitis Virus Confer Heparan Sulfate Interaction, Low Morbidity, and Rapid Clearance from Blood of Mice [PDF]

open access: yes, 2000
The arbovirus, Venezuelan equine encephalitis virus (VEE), causes disease in humans and equines during periodic outbreaks. A murine model, which closely mimics the encephalitic form of the disease, was used to study mechanisms of attenuation. Molecularly
Bernard, Kristen A.   +2 more
core   +2 more sources

Alterations in heparan sulfate proteoglycan synthesis and sulfation and the impact on vascular endothelial function

open access: yesMatrix Biology Plus, 2022
The glycocalyx attached to the apical surface of vascular endothelial cells is a rich network of proteoglycans, glycosaminoglycans, and glycoproteins with instrumental roles in vascular homeostasis.
Danielle Pretorius   +4 more
doaj  

Isolation and Characterization of a Chinese Hamster Ovary Heparan Sulfate Cell Mutant Defective in Both Met Receptor Binding and Hepatocyte Growth Factor NK1/Met Signaling

open access: yesCellular Physiology and Biochemistry, 2018
Background/Aims: The up-regulation of hepatocyte growth factor/receptor, HGF/Met, signal transduction is observed in most of human cancers. Specific heparan sulfate structures enhance the HGF/Met signaling at both cell and animal-based model systems ...
Tong Cao   +11 more
doaj   +1 more source

Damage in porous media due to salt crystallization [PDF]

open access: yesPhysical Review E: Statistical, Nonlinear, and Soft Matter Physics 81 (2010) 066110, 2010
We investigate the origins of salt damage in sandstones for the two most common salts: sodium chloride and sulfate. The results show that the observed difference in damage between the two salts is directly related to the kinetics of crystallization and the interfacial properties of the salt solutions and crystals with respect to the stone. We show that,
arxiv   +1 more source

Heparan sulfate proteoglycans present PCSK9 to the LDL receptor

open access: yesNature Communications, 2017
Coronary artery disease is the main cause of death worldwide and accelerated by increased plasma levels of cholesterol-rich low-density lipoprotein particles (LDL).
Camilla Gustafsen   +13 more
semanticscholar   +1 more source

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

open access: yesAdvanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray   +2 more
wiley   +1 more source

A Genome-Wide CRISPR/Cas9-Based Screen Identifies Heparan Sulfate Proteoglycans as Ligands of Killer-Cell Immunoglobulin-Like Receptors

open access: yesFrontiers in Immunology, 2021
While human leukocyte antigen (HLA) and HLA-like proteins comprise an overwhelming majority of known ligands for NK-cell receptors, the interactions of NK-cell receptors with non-conventional ligands, particularly carbohydrate antigens, is less well ...
Klara Klein   +16 more
doaj   +1 more source

Geochemistry constrains global hydrology on Early Mars [PDF]

open access: yes, 2019
Ancient hydrology is recorded by sedimentary rocks on Mars. The most voluminous sedimentary rocks that formed during Mars' Hesperian period are sulfate-rich rocks, explored by the $Opportunity$ rover from 2004-2012 and soon to be investigated by the $Curiosity$ rover at Gale crater.
arxiv   +1 more source

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

open access: yesAdvanced Science, EarlyView.
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu   +8 more
wiley   +1 more source

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