Fibronectin on extracellular vesicles from microvascular endothelial cells is involved in the vesicle uptake into oligodendrocyte precursor cells. [PDF]
, 2019 学位記番号 ...
Osawa, Sho +2 more
core
Engineering Bacteria as Living Therapeutics in Cancer Therapy
Advanced Science, EarlyView.Through synthetic biology approaches, natural bacteria can be genetically programmed into multifunctional living therapeutics. These engineered bacteria are capable of secreting anti‐tumor factors, displaying tumor‐associated antigens on their surface, or undergoing programmed self‐lysis to release therapeutic cargo.
Jiangfeng Chen +6 more
wiley +1 more source
Glycan Sulfation Modulates Dendritic Cell Biology and Tumor Growth
Neoplasia: An International Journal for Oncology Research, 2016 In cancer, proteoglycans have been found to play roles in facilitating the actions of growth factors, and effecting matrix invasion and remodeling. However, little is known regarding the genetic and functional importance of glycan chains displayed by ...
Roland El Ghazal +7 more
doaj +1 more source
The Extracellular and Cytoplasmic Domains of Syndecan Cooperate Postsynaptically to Promote Synapse Growth at the Drosophila Neuromuscular Junction. [PDF]
PLoS ONE, 2016 The heparan sulfate proteoglycan (HSPG) Syndecan (Sdc) is a crucial regulator of synapse development and growth in both vertebrates and invertebrates. In Drosophila, Sdc binds via its extracellular heparan sulfate (HS) sidechains to the receptor protein ...
Margaret U Nguyen +5 more
doaj +1 more source
Unraveling Heparan Sulfate Proteoglycan Binding Motif for Cancer Cell Selectivity
Frontiers in Oncology, 2019 Membrane heparan sulfate proteoglycans (HSPG) regulate cell proliferation, migration, and differentiation and are therefore considered key players in cancer cell development processes.
Jlenia Brunetti +9 more
doaj +1 more source
Cell Reports, 2018 Summary: Establishing synaptic contacts between neurons is paramount for nervous system function. This process involves transsynaptic interactions between a host of cell adhesion molecules that act in cooperation with the proteins of the extracellular ...
Cesare Orlandi +10 more
doaj +1 more source
Frontiers in Immunology, 2020 Sexually transmitted Hepatitis C virus (HCV) infections and high reinfections are a major concern amongst men who have sex with men (MSM) living with HIV-1 and HIV-negative MSM.
Bernadien M. Nijmeijer +8 more
doaj +1 more source
Heparan sulfate and control of cell division: adhesion and proliferation of mutant CHO-745 cells lacking xylosyl transferase [PDF]
, 2001 We have examined the role of cell surface glycosaminoglycans in cell division: adhesion and proliferation of Chinese hamster ovary (CHO) cells.
Dietrich, Carl Peter +7 more
core +2 more sources
Glycosaminoglycans as Polyelectrolytes: Charge, Interactions, and Applications
ChemBioChem, EarlyView.Glycosaminoglycans (GAGs) are linear, anionic biopolymers with their functions tightly linked to their charge. This review approaches GAGs from a polyelectrolyte perspective, shedding light on how the distribution of sulfate groups and, thus, negative charges, governs their interactions with other biomolecules.
Gergo Peter Szekeres +7 more
wiley +1 more source
Endorepellin remodels the endothelial transcriptome toward a pro-autophagic and pro-mitophagic gene signature. [PDF]
, 2018 Regulation of autophagy by proteolytically cleaved fragments of heparan sulfate proteoglycans is a novel and current research focus in tumor biology. Endorepellin is the C-terminal angiostatic fragment of the heparan sulfate proteoglycan perlecan and ...
Andreuzzi, Eva +5 more
core +1 more source