Results 1 to 10 of about 628,453 (389)

A surprising new hiding place for a dangerous pathogen [PDF]

eLife
The bacterium that causes TB can hide in liver cells called hepatocytes, and reprogram their metabolism for its own benefit.
Sheetal Gandotra, Yogendra Singh
doaj   +2 more sources

Hepatocyte transplantation [PDF]

Journal of Hepatology, 2004
Numerous laboratory studies have shown that hepatocyte transplantation may serve as an alternative to organ transplantation for patients with life-threatening liver disease. Because of the successes of experimental hepatocyte transplantation, institutions have attempted to use this therapy in the clinic for the treatment of a variety of hepatic ...
Ira J, Fox, Jayanta, Roy-Chowdhury
openaire   +7 more sources

Hepatocyte HSPA12A inhibits macrophage chemotaxis and activation to attenuate liver ischemia/reperfusion injury via suppressing glycolysis-mediated HMGB1 lactylation and secretion of hepatocytes

Theranostics, 2023
Rationale: Liver ischemia-reperfusion (LI/R) injury is characterized by two interconnected phases: local ischemia that causes hepatic cell damage to release damage-associated molecular pattern (DAMPs), and DAMPs that recruit immune cells to elicit ...
Shuya Du, Xiaojin Zhang, Yunxiao Jia, Peipei Peng, Qiuyue Kong, Surong Jiang, Yuehua Li, Chuanful Li, Zhengnian Ding, Li Liu   +9 more
semanticscholar   +1 more source

Health concerns of lambs fed cottonseed hulls combined with chitosan by examining the blood metabolic profile and histopathology of the kidney, liver, and rumen

Veterinární Medicína, 2021
This study analysed the effect of cottonseed hulls and chitosan in diets for lambs by determining the blood metabolite profile, and the histopathology of the kidney, liver, and rumen.
T Silva Magalhaes, Carvalho GGP, Santos EM, Lima AES, Freitas Junior JE, Pina DS, Santos SA, Pinto LFB, Mourao GB, Soares FDS, Pereira TCJ, Leite LC   +11 more
doaj   +1 more source

Hepatocytes: A key role in liver inflammation

Frontiers in Immunology, 2023
Hepatocytes, the major parenchymal cells in the liver, are responsible for a variety of cellular functions including carbohydrate, lipid and protein metabolism, detoxification and immune cell activation to maintain liver homeotasis.
Jin Gong, Wei Tu, Jingmei Liu, De-Lu Tian   +3 more
semanticscholar   +1 more source

Liver homeostasis is maintained by midlobular zone 2 hepatocytes

Science, 2021
Zoning in on liver growth For organ homeostasis or regrowth after injury or disease, one or more stem cell populations is needed to rebuild lost tissue. There is considerable debate about the source of new cells in the liver.
Yonglong Wei, Yunguan Wang, Yuemeng Jia, Lin Li, J. Yoon, Shuyuan Zhang, Zixi Wang, Yu Zhang, Min Zhu, Tripti Sharma, Yu-Hsuan Lin, Meng-Hsiung Hsieh, J. Albrecht, P. Le, C. Rosen, Tao Wang, Hao Zhu   +16 more
semanticscholar   +1 more source

Comparison of human hepatoma HepaRG cells with human and rat hepatocytes in uptake transport assays in order to predict drug induced hepatotoxicity [PDF]

, 2013
Human hepatocytes are the gold standard for toxicological studies but they have several drawbacks, like scarce availability, high inter-individual variability, a short lifetime, which limits their applicability.
Baranyai, Zsolt, Jakab, Ferenc, Jemnitz, Katalin, Szabo, Monika, Veres, Zsuzsa   +4 more
core   +10 more sources

Influence of Lavandula angustifolia on metabolic indicators and morphofunctional state of rat organs with a high-fat diet

Біологія тварин, 2022
Herbal preparations recommended in the treatment protocols for metabolic disorders are highly effective and less toxic than chemically synthesized ones.
M. A. Lieshchova, A. V. Oliyar, V. V. Evert   +2 more
doaj   +1 more source

A Quantitative Study on the Protective Effects of Resveratrol against Bisphenol A-induced Hepatotoxicity in Rats: A Stereological Study [PDF]

Iranian Journal of Medical Sciences, 2021
Background: Bisphenol A (BPA) is a widely used chemical with toxic effects on the liver. Resveratrol (RES) is an herbal compound with protective properties. This study aimed to investigate the protective effects of RES on the liver in rats exposed to BPA.
Hossein Bordbar, Fatemeh Soleymani, Elham Nadimi, Seyedeh-Saeedeh Yahyavi, Khatereh Fazelian-Dehkordi   +4 more
doaj   +1 more source

Hepatocyte Transplantation [PDF]

Journal of Clinical and Experimental Hepatology, 2011
Hepatocyte transplantation (HTx) has been developed for use in liver-based metabolic disorders and in acute liver failure. Worldwide, there are around 80 patients that have been transplanted with hepatocytes. Almost all reported studies prove feasibility and safety of the procedure with short- to medium-term success.
Ragai R, Mitry, Robin D, Hughes, Anil, Dhawan   +2 more
openaire   +2 more sources