Results 11 to 20 of about 628,453 (389)

Direct lysosome-based autophagy of lipid droplets in hepatocytes

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Lipid droplets (LDs) are specialized fat-storage organelles that can be used as a fuel source by many types of cells when nutrients are scarce. One mechanism used by hepatocytes (the functional cells of the liver) for the catabolism of these
Ryan J. Schulze, E. Krueger, S. Weller, Katherine M. Johnson, C. Casey, Micah B. Schott, M. McNiven   +6 more
semanticscholar   +1 more source

Hepatocyte Stress Increases Expression of Yes‐Associated Protein and Transcriptional Coactivator With PDZ‐Binding Motif in Hepatocytes to Promote Parenchymal Inflammation and Fibrosis

Hepatology, 2020
Activated hepatocytes are hypothesized to be a major source of signals that drive cirrhosis, but the biochemical pathways that convert hepatocytes into such a state are unclear.
M. Mooring, Brendan H. Fowl, S. Z. Lum, Ye Liu, Kangning Yao, S. Softic, Rory D. Kirchner, Aaron S. Bernstein, A. Singhi, Daniel G. Jay, C. R. Kahn, Fernando D. Camargo, Dean Yimlamai   +12 more
semanticscholar   +1 more source

Different response to epidermal growth factor of hepatocytes in cultures isolated from male or female rat liver. Inhibitor effect of estrogen on binding and mitogenic effect of epidermal growth factor [PDF]

, 1987
Deoxyribonucleic acid (DNA) synthesis in hepatocytes isolated from the livers of male and female rats has been compared in monolayer culture. Plating efficiency, DNA and protein content, viability, and morphologic appearance were the same in cultures ...
Coetzee, M, Francavilla, A, Kam, I, Ove, P, Pellici, R, Polimeno, L, Sciascia, C, Starzl, TE, Todo, S   +8 more
core   +1 more source

Autophagy: A cyto-protective mechanism which prevents primary human hepatocyte apoptosis during oxidative stress [PDF]

, 2012
The role of autophagy in the response of human hepatocytes to oxidative stress remains unknown. Understanding this process may have important implications for the understanding of basic liver epithelial cell biology and the responses of hepatocytes ...
Biederbick A, Christopher J. Weston, David H. Adams, Munafo´ DB, Ricky H. Bhogal, Schroedl C, Simon C. Afford, Stuart M. Curbishley   +7 more
core   +1 more source

Hepatocyte-derived IL-10 plays a crucial role in attenuating pathogenicity during the chronic phase of T. congolense infection [PDF]

, 2020
Bovine African Trypanosomosis is an infectious parasitic disease affecting livestock productivity and thereby impairing the economic development of Sub-Saharan Africa. The most important trypanosome species implicated is T.
Brys, Lea, De Baetselier, Patrick, De Trez, Carl, Korf, Hannelie, Magez, Stefan, Stijlemans, Benoit, Van Ginderachter, Jo A   +6 more
core   +1 more source

Hepatocyte transplantation

Revista Española de Enfermedades Digestivas, 2019
We have read with great interest the study by Vera MC et al. on the intrasplenic transplantation of hepatocytes from donors receiving the carcinogenic drugs diethylnitrosamine (DEN) and 2-actylaminofluorene (2-AAF). The most important conclusion of the study is that there were no signs of tumor progression in the recipient liver at seven and 60 days ...
Javier A, Cienfuegos, Fernando, Rotellar, Víctor, Valenti   +2 more
openaire   +2 more sources

Wharton’s Jelly Mesenchymal Stem Cell: Various Protocols for Isolation and Differentiation of Hepatocyte-Like Cells; Narrative Review [PDF]

Iranian Journal of Medical Sciences, 2019
There are several differentiation methods for mesenchymal stem cells (MSCs) into hepatocyte-like cell. Investigators reported various hepatic differentiation protocols such as modifying culturing conditions or using various growth factors/cytokines.
Negar Varaa, Saeed Azandeh, Zahra Khodabandeh, Anneh Mohammad Gharravi   +3 more
doaj   +1 more source

Modeling hepatitis C virus kinetics during liver transplantation reveals the role of the liver in virus clearance

eLife, 2021
While the liver, specifically hepatocytes, are widely accepted as the main source of hepatitis C virus (HCV) production, the role of the liver/hepatocytes in clearance of circulating HCV remains unknown.
Louis Shekhtman, Miquel Navasa, Natasha Sansone, Gonzalo Crespo, Gitanjali Subramanya, Tje Lin Chung, E Fabian Cardozo-Ojeda, Sofía Pérez-del-Pulgar, Alan S Perelson, Scott J Cotler, Xavier Forns, Susan L Uprichard, Harel Dahari   +12 more
doaj   +1 more source

Isolated Hepatocytes versus Hepatocyte Spheroids: In Vitro Culture of Rat Hepatocytes [PDF]

Cell Transplantation, 2005
The use of hepatocytes that express liver-specific functions to develop an artificial liver is promising. Unfortunately, the loss of specialized liver functions (dedifferentiation) is still a major problem. Different techniques, such as collagen entrapment, spherical multicellular aggregates (spheroids), and coculture of hepatocytes with extracellular
Giovanni Ambrosino, Stefano M. M. Basso, Sergio Varotto, Enrico Zardi, Antonio Picardi, Davide F. D'amico   +5 more
openaire   +4 more sources

Hepatocytes direct the formation of a pro-metastatic niche in the liver.

Nature, 2019
The liver is the most common site of metastatic disease1. Although this metastatic tropism may reflect the mechanical trapping of circulating tumour cells, liver metastasis is also dependent, at least in part, on the formation of a ‘pro-metastatic’ niche
Jae W Lee, M. Stone, P. Porrett, Stacy K. Thomas, Chad A. Komar, Joey H. Li, D. Delman, Kathleen Graham, W. Gladney, Xianxian Hua, Taylor A. Black, Austin L. Chien, Krishna S. Majmundar, Jeffrey C. Thompson, S. Yee, M. O'Hara, C. Aggarwal, Dong Xin, A. Shaked, Mingming Gao, Dexi Liu, M. Borad, R. Ramanathan, E. Carpenter, A. Ji, M. de Beer, F. C. de Beer, N. Webb, G. Beatty   +28 more
semanticscholar   +1 more source