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Hepatocyte transplantation [PDF]

Journal of Hepatology, 2004
Numerous laboratory studies have shown that hepatocyte transplantation may serve as an alternative to organ transplantation for patients with life-threatening liver disease. Because of the successes of experimental hepatocyte transplantation, institutions have attempted to use this therapy in the clinic for the treatment of a variety of hepatic ...
Ira J, Fox, Jayanta, Roy-Chowdhury
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Hepatocyte Transplantation [PDF]

Journal of Clinical and Experimental Hepatology, 2011
Hepatocyte transplantation (HTx) has been developed for use in liver-based metabolic disorders and in acute liver failure. Worldwide, there are around 80 patients that have been transplanted with hepatocytes. Almost all reported studies prove feasibility and safety of the procedure with short- to medium-term success.
Ragai R, Mitry, Robin D, Hughes, Anil, Dhawan   +2 more
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Hepatocyte transplantation

Revista Española de Enfermedades Digestivas, 2019
We have read with great interest the study by Vera MC et al. on the intrasplenic transplantation of hepatocytes from donors receiving the carcinogenic drugs diethylnitrosamine (DEN) and 2-actylaminofluorene (2-AAF). The most important conclusion of the study is that there were no signs of tumor progression in the recipient liver at seven and 60 days ...
Javier A, Cienfuegos, Fernando, Rotellar, Víctor, Valenti   +2 more
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Isolated Hepatocytes versus Hepatocyte Spheroids: In Vitro Culture of Rat Hepatocytes [PDF]

Cell Transplantation, 2005
The use of hepatocytes that express liver-specific functions to develop an artificial liver is promising. Unfortunately, the loss of specialized liver functions (dedifferentiation) is still a major problem. Different techniques, such as collagen entrapment, spherical multicellular aggregates (spheroids), and coculture of hepatocytes with extracellular
Giovanni Ambrosino, Stefano M. M. Basso, Sergio Varotto, Enrico Zardi, Antonio Picardi, Davide F. D'amico   +5 more
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Recent Advances in Models of Immune-Mediated Drug-Induced Liver Injury

Frontiers in Toxicology, 2021
Hepatic inflammation is a key feature of a variety of liver diseases including drug-induced liver injury (DILI), orchestrated by the innate immune response (Kupffer cells, monocytes, neutrophils, dendritic cells) and the adaptive immune system (T cells ...
Farah Tasnim, Farah Tasnim, Xiaozhong Huang, Xiaozhong Huang, Xiaozhong Huang, Christopher Zhe Wei Lee, Christopher Zhe Wei Lee, Christopher Zhe Wei Lee, Florent Ginhoux, Florent Ginhoux, Florent Ginhoux, Florent Ginhoux, Florent Ginhoux, Hanry Yu, Hanry Yu, Hanry Yu, Hanry Yu, Hanry Yu, Hanry Yu   +18 more
doaj   +1 more source

Development and characterization of a new human hepatic cell line [PDF]

, 2015
The increasing demand and hampered use of primary human hepatocytes for research purposes have urged scientists to search for alternative cell sources, such as immortalized hepatic cell lines.
Berx, Geert, De Craene, Bram, De Kock, Joey, Ramboer, Eva, Rogiers, Vera, Vanhaecke, Tamara, Vinken, Mathieu   +6 more
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Features of iron homeostasis in patients with steatohepatitis of alcoholic and non-alcoholic etiology and its correlation with the intensity of oxidative stress and apoptosis

Journal of Education, Health and Sport, 2021
Topicality. Comorbid course of alcoholic steatohepatitis (ASH) and non alcoholic steatohepatitis (NASH) with dysmetabolic iron overload syndrome (DIOS) is caused by the cascade of interload reactions, which may contribute to the progression of the ...
O. S. Khukhlina, T. M. Antofiichuk, M. P. Antofiichuk   +2 more
doaj   +1 more source

A fresh look at augmenter of liver regeneration in rats. [PDF]

, 1999
Augmenter of liver regeneration (ALR) is a hepatotrophic protein originally identified by bioassay in regenerating rat and canine livers following partial hepatectomy and in the hyperplastic livers of weanling rats, but not in resting adult livers.
Abyss, Armendariz-Borunda, Ascoli, Blomquist, Bucher, Bucher, Bucher, Dallman, Dallman, Davies, DeHemptinne, Earp, Evarts, Fausto, Fausto, Fausto, Francavilla, Francavilla, Francavilla, Francavilla, Francavilla, Francavilla, Francavilla, Francavilla, Francavilla, Gabriel, Gandhi, Gandhi, Geerts, Giorda, Grisham, Hagiya, Hagiya, Harding, Higgins, Hully, Itoh, Koch, LaBrecque, Lambotte, Leffert, Leffert, Makowka, Marchioro, Marchioro, Mars, Masumoto, Mazzaferro, McJunkin, Mead, Meyer, Michalopoulos, Michalopoulos, Naldini, Pause, Rilo, Rubin, Russell, Sakamoto, Sasaki, Schirmacher, Shaw, Siekierka, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Steer, Steiner, Steiner, Subbotin, Teir, Terblanche, Vujanovic, Wang, Wang, Webber, Webber, Yamate, Younger, Zindi   +86 more
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METABOLIC CHANGES IN HEPATOCYTES OF EXPERIMENTAL ANIMALS AFTER PROLONGED TREATMENT WITH SIMVASTATIN

Медицинский вестник Юга России, 2013
Purpose: To analyse the metabolic changes in the liver cells of experimental animals after prolonged treatment with simvastatin.Materials and Methods: Our experiment was taken on 40 rates (males) which were divided on two groups: 1-st (control) – 20 ...
Z. I. Mikashinovich, E. S. Belousova, E. G. Telesmanich   +2 more
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ABCC6 is a basolateral plasma membrane protein [PDF]

, 2013
RATIONALE:: ABCC6 plays a crucial role in ectopic calcification; mutations of the gene cause pseudoxanthoma elasticum and general arterial calcification of infancy.
Apana, A., Brampton, C., Ilias, A., Le Saux, O., Martin, L., Monostory, K., Paku, S., Pomozi, V., Sarkadi, B., Szakacs, G., Szeri, F., Varadi, A.   +11 more
core   +4 more sources