Results 21 to 30 of about 406,566 (292)
Hepatocyte Differentiation [PDF]
, 2010 Increasingly, research suggests that for certain systems, animal models are insufficient for human toxicology testing. The development of robust, in vitro models of human toxicity is required to decrease our dependence on potentially misleading in vivo animal studies.
Katy M, Olsavsky Goyak +2 more
openaire +2 more sources
Cell Reports, 2021 Summary: Chronic injury to hepatocytes results in inflammation, steatohepatitis, fibrosis, and nonalcoholic fatty liver disease (NAFLD). The tetraspanin TM4SF5 is implicated in fibrosis and cancer.
Eunmi Kim +10 more
doaj +1 more source
Mechanisms of transcriptional control of glucose metabolism in hepatocytes
Сахарный диабет, 2016 The hepatic tissue plays a key role in the regulation and maintenance of stable blood glucose levels. The liver is the main gluconeogenesis organ of the body and is under constant hormonal control to determine the metabolic activity of hepatocytes ...
Konstantin Y. Kulebyakin +3 more
doaj +1 more source
Deficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arrest [PDF]
, 2015 TGFbeta is critical to control hepatocyte proliferation by inducing G1-growth arrest through multiple pathways leading to inhibition of E2F transcription activity.
Bellamy, Christopher O +4 more
core +1 more source
Cytomorphological Changes in the Hepate of the White Sea Coastal Cod (Gadus morhua maris-albi Derjugin, 1920) during Parasitic Invasions [PDF]
Учёные записки Казанского университета: Серия Естественные науки, 2015 The cod Gadus morhua maris-albi is one of the most heavily infested fish species in the White Sea. The fish liver (hepate) is a convenient model to study the pathogenesis in parasitosis.
Shakurova N.V., Kudryavtseva E.V.
doaj
Poultry Science, 2020 In avian species, liver lipid metabolism plays an important role in egg laying performance. Previous studies indicate that betaine supplementation in laying hens improves egg production.
Nagmeldin A. Omer +7 more
doaj +1 more source
Signaling Nodes Associated with Endoplasmic Reticulum Stress during NAFLD Progression
Biomolecules, 2021 Excess and sustained endoplasmic reticulum (ER) stress, paired with a failure of initial adaptive responses, acts as a critical trigger of nonalcoholic fatty liver disease (NAFLD) progression.
Ja Hyun Koo, Chang Yeob Han
doaj +1 more source
Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte [PDF]
, 2014 The complex spatial and paracrine relationships between the various liver histotypes are essential for proper functioning of the hepatic parenchymal cells.
Fausto N +6 more
core +3 more sources
Разработка и регистрация лекарственных средств, 2023 Introduction. The high doses of vitamin D lead to undesirable side effects such as hypercalcemia. Paricalcitol (PC) is a biologically active synthetic substance that selectively binds to intracellular vitamin D receptors and does not cause hypercalcemia.
T. P. Sataieva +4 more
doaj +1 more source
IGFBP-5 as a biomarker of de-differentiation in hepatocytes [PDF]
, 2011 Describes IGFBP-5 as a biomarker of de-differentiation in hepatocytes presented at the 47th Congress of the European-Societies-of ...
Flint, David +3 more
core +1 more source