Results 21 to 30 of about 628,453 (389)

The adipokine sFRP4 induces insulin resistance and lipogenesis in the liver [PDF]

, 2019
Secreted frizzled-related protein (sFRP) 4 is an adipokine with increased expression in white adipose tissue from obese subjects with type 2 diabetes and non-alcoholic fatty liver disease (NAFLD).
Al-Hasani, Hadi, Barbosa, David, Fahlbusch, Pia, Herzfeld de Wiza, Daniella, Hörbelt, Tina, Knebel, Birgit, Kotzka, Jorg, Lapauw, Bruno, Müller-Wieland, Dirk, Ouwens, Margriet, Thoresen, G Hege, Van de Velde, Frederique, Van Nieuwenhove, Yves   +12 more
core   +1 more source

Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes

Journal of Cell Biology, 2019
Lipolysis and lipophagy are thought to be distinct mechanisms for lipid droplet catabolism. In hepatocytes, Schott et al. report that these pathways may operate synergistically: the lipolysis enzyme ATGL targets large LDs upstream of lipophagy, which is ...
Micah B. Schott, S. Weller, Ryan J. Schulze, E. Krueger, Kristina Drizyte-Miller, C. Casey, M. McNiven   +6 more
semanticscholar   +1 more source

Role of hepatic stellate cells in liver ischemia-reperfusion injury

Frontiers in Immunology, 2022
Liver ischemia-reperfusion injury (IRI) is a major complication of liver trauma, resection, and transplantation. IRI may lead to liver dysfunction and failure, but effective approach to address it is still lacking.
Yuming Peng, Yuming Peng, Qiang Yin, Qiang Yin, Miaoxian Yuan, Miaoxian Yuan, Lijian Chen, Lijian Chen, Xinyi Shen, Xinyi Shen, Weixin Xie, Weixin Xie, Jinqiao Liu   +12 more
doaj   +1 more source

Development and characterization of a new human hepatic cell line [PDF]

, 2015
The increasing demand and hampered use of primary human hepatocytes for research purposes have urged scientists to search for alternative cell sources, such as immortalized hepatic cell lines.
Berx, Geert, De Craene, Bram, De Kock, Joey, Ramboer, Eva, Rogiers, Vera, Vanhaecke, Tamara, Vinken, Mathieu   +6 more
core   +3 more sources

Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo

Journal of Lipid Research, 2008
Scavenger receptor class B type I (SR-BI) functions as an HDL receptor that promotes the selective uptake of cholesteryl esters (CEs). The physiological role of SR-BI in VLDL metabolism, however, is largely unknown.
Miranda Van Eck, Menno Hoekstra, Ruud Out, I. Sophie T. Bos, J. Kar Kruijt, Reeni B. Hildebrand, Theo J.C. Van Berkel   +6 more
doaj   +1 more source

A fresh look at augmenter of liver regeneration in rats. [PDF]

, 1999
Augmenter of liver regeneration (ALR) is a hepatotrophic protein originally identified by bioassay in regenerating rat and canine livers following partial hepatectomy and in the hyperplastic livers of weanling rats, but not in resting adult livers.
Abyss, Armendariz-Borunda, Ascoli, Blomquist, Bucher, Bucher, Bucher, Dallman, Dallman, Davies, DeHemptinne, Earp, Evarts, Fausto, Fausto, Fausto, Francavilla, Francavilla, Francavilla, Francavilla, Francavilla, Francavilla, Francavilla, Francavilla, Francavilla, Gabriel, Gandhi, Gandhi, Geerts, Giorda, Grisham, Hagiya, Hagiya, Harding, Higgins, Hully, Itoh, Koch, LaBrecque, Lambotte, Leffert, Leffert, Makowka, Marchioro, Marchioro, Mars, Masumoto, Mazzaferro, McJunkin, Mead, Meyer, Michalopoulos, Michalopoulos, Naldini, Pause, Rilo, Rubin, Russell, Sakamoto, Sasaki, Schirmacher, Shaw, Siekierka, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Steer, Steiner, Steiner, Subbotin, Teir, Terblanche, Vujanovic, Wang, Wang, Webber, Webber, Yamate, Younger, Zindi   +86 more
core   +1 more source

ABCC6 is a basolateral plasma membrane protein [PDF]

, 2013
RATIONALE:: ABCC6 plays a crucial role in ectopic calcification; mutations of the gene cause pseudoxanthoma elasticum and general arterial calcification of infancy.
Apana, A., Brampton, C., Ilias, A., Le Saux, O., Martin, L., Monostory, K., Paku, S., Pomozi, V., Sarkadi, B., Szakacs, G., Szeri, F., Varadi, A.   +11 more
core   +4 more sources

Hepatocyte Differentiation [PDF]

, 2010
Increasingly, research suggests that for certain systems, animal models are insufficient for human toxicology testing. The development of robust, in vitro models of human toxicity is required to decrease our dependence on potentially misleading in vivo animal studies.
Katy M, Olsavsky Goyak, Elizabeth M, Laurenzana, Curtis J, Omiecinski   +2 more
openaire   +2 more sources

Mechanisms of transcriptional control of glucose metabolism in hepatocytes

Сахарный диабет, 2016
The hepatic tissue plays a key role in the regulation and maintenance of stable blood glucose levels. The liver is the main gluconeogenesis organ of the body and is under constant hormonal control to determine the metabolic activity of hepatocytes ...
Konstantin Y. Kulebyakin, Zhanna A. Akopyan, Tatiana N. Kochegura, Dmitry N. Penkov   +3 more
doaj   +1 more source

Intestinal Epithelial Cell-Derived Extracellular Vesicles Modulate Hepatic Injury via the Gut-Liver Axis During Acute Alcohol Injury

Frontiers in Pharmacology, 2020
Binge drinking, i.e., heavy episodic drinking in a short time, has recently become an alarming societal problem with negative health impact. However, the harmful effects of acute alcohol injury in the gut-liver axis remain elusive.
Arantza Lamas-Paz, Arantza Lamas-Paz, Laura Morán, Laura Morán, Jin Peng, Beatriz Salinas, Beatriz Salinas, Beatriz Salinas, Beatriz Salinas, Nuria López-Alcántara, Svenja Sydor, Ramiro Vilchez-Vargas, Iris Asensio, Iris Asensio, Fengjie Hao, Fengjie Hao, Fengjie Hao, Kang Zheng, Kang Zheng, Kang Zheng, Beatriz Martín-Adrados, Beatriz Martín-Adrados, Laura Moreno, Laura Moreno, Angel Cogolludo, Angel Cogolludo, Manuel Gómez del Moral, Manuel Gómez del Moral, Lars Bechmann, Eduardo Martínez-Naves, Eduardo Martínez-Naves, Javier Vaquero, Javier Vaquero, Rafael Bañares, Rafael Bañares, Yulia A. Nevzorova, Yulia A. Nevzorova, Yulia A. Nevzorova, Francisco Javier Cubero, Francisco Javier Cubero   +39 more
doaj   +1 more source