Results 61 to 70 of about 5,487 (200)

Transformation Resistance in a Premature Aging Disorder Identifies a Tumor-Protective Function of BRD4

Cell Reports, 2014
Summary: Advanced age and DNA damage accumulation are prominent risk factors for cancer. The premature aging disorder Hutchinson-Gilford progeria syndrome (HGPS) provides a unique opportunity for studying the interplay between DNA damage and aging ...
Patricia Fernandez, Paola Scaffidi, Elke Markert, Ji-Hyeon Lee, Sushil Rane, Tom Misteli   +5 more
doaj   +1 more source

Accurate detection of dysmorphic nuclei using dynamic programming and supervised classification [PDF]

, 2017
A vast array of pathologies is typified by the presence of nuclei with an abnormal morphology. Dysmorphic nuclear phenotypes feature dramatic size changes or foldings, but also entail much subtler deviations such as nuclear protrusions called blebs.
Catrysse, Hannes, De Vos, Winnok, De Vylder, Jonas, Philips, Wilfried, Robijns, Joke, Verschuuren, Marlies   +5 more
core   +3 more sources

HPoolGCL: Augmentation‐Free Cross‐Granularity Graph Contrastive Learning With Hierarchical Pooling

CAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT Graph contrastive learning (GCL) has emerged as a dominant paradigm for self‐supervised representation learning for attributed graph data. However, existing GCL methods heavily rely on empirical graph data augmentation, which may distort intrinsic graph semantics and produce poor generalisation without carefully chosen or designed augmentation
Fenglin Cen, Shijie Liu, Quan Feng, Tiantian He, Ji Xu   +4 more
wiley   +1 more source

PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes

British Journal of Pharmacology, EarlyView.
Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier, David Spähn, David Arturo Juarez Lopez, Judith L. Nono, Judith Seigner, Lisa Jacob, Siegfried Ussar, Robert Lukowski, Andreas L. Birkenfeld, Gencer Sancar   +9 more
wiley   +1 more source

Hutchinson–Gilford Progeria Syndrome: Clinical and Molecular Characterization

The Application of Clinical Genetics, 2020
Harry Pachajoa,1,2 Angelica Claros-Hulbert,3,4 Ximena García-Quintero,3,4 Lina Perafan,1 Andres Ramirez,5 Andres F Zea-Vera6 1Faculty of Health Sciences, Congenital Anomalies and Rare Diseases Investigation Center (CIACER), Universidad Icesi, Cali,
Pachajoa H, Claros-Hulbert A, García-Quintero X, Perafan L, Ramirez A, Zea-Vera AF   +5 more
doaj  

Large-scale Heteroscedastic Regression via Gaussian Process

, 2020
Heteroscedastic regression considering the varying noises among observations has many applications in the fields like machine learning and statistics.
Cai, Jianfei, Liu, Haitao, Ong, Yew-Soon
core   +1 more source

DNA methylation dynamics in aging: How far are we from understanding the mechanisms? [PDF]

, 2018
DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered.Here we discuss the current knowledge ...
Caiafa, Paola, Ciccarone, Fabio, Tagliatesta, Stefano, Zampieri, Michele   +3 more
core   +1 more source

High levels of serum cholesterol increase the risk of developing vessel co‐opting tumors in colorectal cancer liver metastases

The FEBS Journal, EarlyView.
High serum cholesterol is linked to colorectal cancer liver metastases (CRCLM) subtypes with poor survival (replacement pattern). Levels of cholesterol under 4 mmol·L−1 correlated with better survival and a desmoplastic pattern subtype. Furthermore, in vivo PCSK9 inhibitor evolocumab, which lowers cholesterol, reduced liver metastases.
Amatzia Gantz, Audrey Kapelanski‐Lamoureux, Miran Rada, Lucyna Krzywon, Migmar Tsamchoe, Anastasia Tsatoumas, Stephanie K. Petrillo, Nabil G. Seidah, Anthoula Lazaris, Peter Metrakos   +9 more
wiley   +1 more source

Hutchinson Gilford Progeria Syndrome: A Therapeutic Approach via Adenoviral Delivery of CRISPR/cas Genome Editing System [PDF]

, 2014
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare human genetic disease caused by mutations in the LMNA gene. LMNA codes for structural components of the nuclear lamina. Alterations of nuclear lamina lead to a very variable class of diseases known as
ARANCIO, Walter, Genovese, SI, GIORDANO, Carla, PIZZOLANTI, Giuseppe   +3 more
core   +1 more source

Behind the scenes of the HGP [PDF]

Nature Genetics, 2003
Future geneticists will probably reflect on the Human Genome Project (HGP) as a milestone in their field. Perhaps it will be recognized alongside the chromosome theory of inheritance, the transforming material as DNA, the double helical structure for the genetic material and the cracking of the genetic code.
openaire   +1 more source