Results 71 to 80 of about 5,487 (200)

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson–Gilford progeria syndrome

Cell Death and Disease, 2022
Hutchinson–Gilford progeria syndrome (HGPS) is a rare, fatal disease caused by Lamin A mutation, leading to altered nuclear architecture, loss of peripheral heterochromatin and deregulated gene expression.
Giorgia Catarinella, Chiara Nicoletti, Andrea Bracaglia, Paola Procopio, Illari Salvatori, Marilena Taggi, Cristiana Valle, Alberto Ferri, Rita Canipari, Pier Lorenzo Puri, Lucia Latella   +10 more
doaj   +1 more source

Delineating the molecular landscape of different histopathological growth patterns in colorectal cancer liver metastases

Frontiers in Immunology, 2022
BackgroundHistopathological growth patterns (HGPs) have shown important prognostic values for patients with colorectal cancer liver metastases, but the potential molecular mechanisms remain largely unknown.MethodsWe performed an exploratory analysis by ...
Mingtao Hu, Mingtao Hu, Zhigang Chen, Zhigang Chen, Dandan Hu, Dandan Hu, Shaoyan Xi, Shaoyan Xi, Deshen Wang, Deshen Wang, Xiaolong Zhang, William Pat Fong, William Pat Fong, Lei Wen, Lei Wen, Yanyu Cai, Yanyu Cai, Yunfei Yuan, Yunfei Yuan, Binkui Li, Binkui Li, Xiaojun Wu, Xiaojun Wu, Zhenhai Lu, Zhenhai Lu, Gong Chen, Gong Chen, Liren Li, Liren Li, Peirong Ding, Peirong Ding, Zhizhong Pan, Zhizhong Pan, Desen Wan, Desen Wan, Ziming Du, Ziming Du, Minshan Chen, Minshan Chen, Yuhong Li, Yuhong Li   +40 more
doaj   +1 more source

Genetics and Genomics in Sickle Cell Disease in Africa

American Journal of Hematology, Volume 101, Issue S1, Page 47-55, April 2026.
ABSTRACT Advanced genomic technologies are revolutionizing our ability to understand complex diseases. Large‐scale population studies are needed to realize the potential of using individual genetic information to personalize treatments for better patient outcomes for chronic non‐communicable diseases, such as sickle cell disease (SCD).
Siana Nkya, Julie Makani, Jonathan M. Flanagan   +2 more
wiley   +1 more source

DNA Methylation Signatures of Cellular Senescence Are Not Reversed by Senolytic Treatment

Aging Cell, Volume 25, Issue 3, March 2026.
We found very little overlap between CpGs that were correlated with in vitro senescence, chronological age, and mortality. While we were able to train epigenetic clocks with CpGs that accelerated with cellular senescence, these clocks did not decelerate with Senolytic treatment. ABSTRACT Epigenetic clocks are commonly used aging biomarkers based on DNA
Jessica Kasamoto, John González, Yaroslav Markov, Raghav Sehgal, Edwin Lee, Varun B. Dwaraka, Ryan Smith, Albert T. Higgins‐Chen   +7 more
wiley   +1 more source

Impact of Combined Baricitinib and FTI Treatment on Adipogenesis in Hutchinson–Gilford Progeria Syndrome and Other Lipodystrophic Laminopathies

Cells, 2023
Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disease that causes premature aging symptoms, such as vascular diseases, lipodystrophy, loss of bone mineral density, and alopecia. HGPS is mostly linked to a heterozygous and de novo mutation
Ramona Hartinger, Eva-Maria Lederer, Elisa Schena, Giovanna Lattanzi, Karima Djabali   +4 more
doaj   +1 more source

European Working Group on Sarcopenia in Older People Algorithm: Step‐by‐Step Relation With Length of Hospitalization

Journal of the American Geriatrics Society, Volume 74, Issue 3, Page 760-769, March 2026.
This study globally shows that the EWGSOP2 algorithm is a valid tool even in hospitalized older patients. In fact, every step enhances the predictive validity of the algorithm, suggesting, however, that SARC‐F and muscle strength can still be valuable tools for negative clinical outcomes when body composition data are not available.
Elena Zoico, Silvia Urbani, Anna Giani, Francesco Fantin, Alessandro Gavras, John A. Batsis, Rocco Micciolo, Mauro Zamboni   +7 more
wiley   +1 more source

Low levels of the reverse transactivator fail to induce target transgene expression in vascular smooth muscle cells. [PDF]

PLoS ONE, 2014
Hutchinson-Gilford progeria syndrome (HGPS) is a genetic disease with multiple features that are suggestive of premature aging. Most patients with HGPS carry a mutation on one of their copies of the LMNA gene.
Nikenza Viceconte, Tomás McKenna, Maria Eriksson   +2 more
doaj   +1 more source

Understanding Health and Disease with Multidimensional Single-Cell Methods

, 2013
Current efforts in the biomedical sciences and related interdisciplinary fields are focused on gaining a molecular understanding of health and disease, which is a problem of daunting complexity that spans many orders of magnitude in characteristic length
Banavar, Jayanth R., Candia, Julián, Losert, Wolfgang   +2 more
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, Volume 600, Issue 4, Page 392-417, February 2026.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source