Results 81 to 90 of about 5,487 (200)

Recent Advances in Animal and Human Pluripotent Stem Cell Modeling of Cardiac Laminopathy [PDF]

, 2016
published_or_final_versio
Jiang, Y, Lai, KWH, Lau, VYM, Lee, YK, Ng, KM, RAN, X, Siu, DCW, Tse, HF   +7 more
core   +1 more source

Personalized Models of Biological Barriers and Their Diseases: Recent Progress with Organs‐On‐Chips

Advanced Biology, Volume 10, Issue 2, February 2026.
Buck and Bugter et al. explore the architectural diversity and physiological functions of human barrier systems and reveal how organ‐on‐chip platforms, particularly those integrating patient‐derived cells, are advancing barrier disease modeling. They highlight how emerging biological and technological advances can be used to bridge the gap between ...
Franziska Buck, Jeroen Bugter, Gizem Yorukoglu, Mina Kazemzadeh Dastjerd, Thomas E. Winkler   +4 more
wiley   +1 more source

On the succinctness of query rewriting over shallow ontologies [PDF]

, 2014
We investigate the succinctness problem for conjunctive query rewritings over OWL2QL ontologies of depth 1 and 2 by means of hypergraph programs computing Boolean functions. Both positive and negative results are obtained.
Abiteboul S., Baget J.-F., Bienvenu M., Chortaras A., Eiter T., Gottlob G., Kikot S., Kikot S., Lutz C., Lutz C., Poggi A., Pérez-Urbina H., Pérez-Urbina H., Razborov A., Razborov A., Rodríguez-Muro M., Rosati R., Yannakakis M.   +17 more
core   +2 more sources

Quantifying Vein Network Permeability in Dehydrated Serpentinites Using Thermodynamics and Generative AI

Journal of Geophysical Research: Solid Earth, Volume 131, Issue 2, February 2026.
Abstract Fluids released from subducting hydrated rocks influence volcanism, tectonics, and geochemical cycling, but the mechanisms of fluid escape in subduction zones remain poorly understood. We address this issue by investigating the Erro‐Tobbio meta‐serpentinites (ET‐MS), Italy, exhumed serpentinite rocks that preserve extensive dehydration vein ...
Austin Arias, Lisa Eberhard, Andreas Beinlich, Timm John, Alissa Kotowski, Oliver Plümper   +5 more
wiley   +1 more source

Comparative transcriptome analysis of Parkinson’s disease and Hutchinson-Gilford progeria syndrome reveals shared susceptible cellular network processes

BMC Medical Genomics, 2020
Background Parkinson’s Disease (PD) and Hutchinson-Gilford Progeria Syndrome (HGPS) are two heterogeneous disorders, which both display molecular and clinical alterations associated with the aging process.
Diana M. Hendrickx, Enrico Glaab
doaj   +1 more source

Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive progeroid traits [PDF]

, 2018
Human AKTIP and mouse Ft1 are orthologous ubiquitin E2 variant proteins involved in telomere maintenance and DNA replication. AKTIP also interacts with A- and B-type lamins.
Ana, Cumano, Bartolazzi, Armando, Bucciarelli, Elisabetta, Burla, Romina, Carcuro, Mariateresa, DEL GIUDICE, Simona, Gatti, Maurizio, Giulia, Piaggio, Ilaria, Virdia, Isabella, Manni, LA TORRE, Mattia, Merigliano, Chiara, Mottini, Carla, RAMPIONI VINCIGUERRA, GIAN LUCA, Riminucci, Mara, Saggio, Isabella, Silvia, Soddu, Verni', Fiammetta, Zanetti, Giorgia   +18 more
core   +1 more source

Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging

Aging Cell, Volume 25, Issue 2, February 2026.
Mouse models revealed age‐associated increased circumferential stiffness of the proximal pulmonary artery that was associated with reorientation of collagen and decreased function of the lung and right ventricle. Age‐related transcriptional changes were indicative of senescence, ECM turnover, TGFβ signaling, and altered intercellular signaling among ...
Ruben De Man, Zhongyu Cai, Pramath Doddaballapur, Nicole Guerrera, Alexandria Regan, Liqin Lin, Erica Schwarz, Aurelien Justet, Nebal S. Abu Hussein, Jack Di Palo, Cristina Cavinato, Micha Sam B. Raredon, Paul M. Heerdt, Inderjit Singh, Xiting Yan, Min‐Jong Kang, Danielle R. Bruns, Patty J. Lee, George Tellides, Jay D. Humphrey, Naftali Kaminski, Abhay B. Ramachandra, Edward P. Manning   +22 more
wiley   +1 more source

HGP-write : après la lecture, l’écriture ? [PDF]

médecine/sciences, 2016
The recently proposed « HGP-write » project aims to synthetize a full human genome and to introduce it into cells. This ambitious endeavour is fraught with financial and technical uncertainties and, if successful, would make « synthetic humans » a definite possibility even though this is not part of its announced goals.
openaire   +2 more sources

Novel treatment strategies for chronic kidney disease: insights from the animal kingdom [PDF]

, 2018
Many of the >2 million animal species that inhabit Earth have developed survival mechanisms that aid in the prevention of obesity, kidney disease, starvation, dehydration and vascular ageing; however, some animals remain susceptible to these ...
Arnold, Walter, Johnson, Richard J., Kuro-o, Makoto, Lanaspa, Miguel, Painer, Johanna, Ruf, Thomas, Shiels, Paul G., Stenvinkel, Peter   +7 more
core   +1 more source

Informing Dose for Pediatric Rare Diseases—A Survey of Recent Orphan Drugs Approvals

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Collectively, pediatric rare diseases affect millions of children worldwide. Yet, treatment options are limited. Dose selection presents unique challenges in pediatric rare disease drug development. Traditional dose‐finding approaches are impractical for these populations, and conventional pediatric dosing methods like exposure matching face ...
Elimika Pfuma Fletcher, Chloe Kim, Hannah Mei, Bilal AbuAsal, Sherbet Samuels, Rajanikanth Madabushi, Anuradha Ramamoorthy   +6 more
wiley   +1 more source