The role of histone acetyltransferases in normal and malignant hematopoiesis [PDF]
Frontiers in Oncology, 2015 Histone or non-histone protein acetylation plays important roles in all kinds of cellular events, including the normal and abnormal development of blood cells, through changing the epigenetic status of chromatin and regulating non-histone protein’s ...
Xiao-Jian eSun +4 more
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The Role of Histone Acetyltransferases and Histone Deacetylases in Photoreceptor Differentiation and Degeneration. [PDF]
Int J Med Sci, 2020 Photoreceptors are critical components of the retina and play a role in the first step of the conversion of light to electrical signals. The differentiation and degeneration of photoreceptors are regulated by specific genes and proteins.
Zhao M, Tao Y, Peng GH.
europepmc +4 more sources
Histone Acetyltransferases and Stem Cell Identity. [PDF]
Cancers (Basel), 2021 Simple Summary Gene regulation is the major mechanism that allows us to develop from a single cell to a fully formed adult body containing numerous organs and tissues, >200 cell types and a total of about 50 trillion cells. One of the ways our cells turn
He R, Dantas A, Riabowol K.
europepmc +5 more sources
HAC1 and HAF1 Histone Acetyltransferases Have Different Roles in UV-B Responses in Arabidopsis [PDF]
Frontiers in Plant Science, 2017 Arabidopsis has 12 histone acetyltransferases grouped in four families: the GNAT/HAG, the MYST/HAM, the p300/CBP/HAC and the TAFII250/HAF families. We previously showed that ham1 and ham2 mutants accumulated higher damaged DNA after UV-B exposure than WT
Julieta P. Fina +4 more
doaj +3 more sources
Histone acetyltransferases CBP/p300 in tumorigenesis and CBP/p300 inhibitors as promising novel anticancer agents. [PDF]
Theranostics, 2022 The histone acetyltransferases CBP and p300, often referred to as CBP/p300 due to their sequence homology and functional overlap and co-operation, are emerging as critical drivers of oncogenesis in the past several years.
Chen Q +5 more
europepmc +2 more sources
Garcinol and Anacardic Acid, Natural Inhibitors of Histone Acetyltransferases, Inhibit Rhabdomyosarcoma Growth and Proliferation [PDF]
Molecules, 2023 Rhabdomyosarcoma (RMS) is a malignant tumour of the soft tissues. There are two main histopathological types: alveolar and embryonal. RMS occurs mainly in childhood and is a result of the deregulation of growth and differentiation of muscle cell ...
Patrycja Tomasiak +5 more
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Molecular characterization and modulated expression of histone acetyltransferases during cold response of the tick Dermacentor silvarum (Acari: Ixodidae) [PDF]
Parasites & Vectors, 2023 Background Histone acetylation is involved in the regulation of stress responses in multiple organisms. Dermacentor silvarum is an important vector tick species widely distributed in China, and low temperature is a crucial factor restricting the ...
Tingwei Pei +8 more
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The Fusarium graminearum Histone Acetyltransferases Are Important for Morphogenesis, DON Biosynthesis, and Pathogenicity. [PDF]
Front Microbiol, 2018 Post-translational modifications of chromatin structure by histone acetyltransferase (HATs) play a central role in the regulation of gene expression and various biological processes in eukaryotes.
Kong X +8 more
europepmc +2 more sources
Epigenetics in ovarian cancer: premise, properties, and perspectives [PDF]
Molecular Cancer, 2018 Malignant ovarian tumors bear the highest mortality rate among all gynecological cancers. Both late tumor diagnosis and tolerance to available chemical therapy increase patient mortality.
Qilian Yang +16 more
doaj +3 more sources
Roles of histone acetylation sites in cardiac hypertrophy and heart failure
Frontiers in Cardiovascular Medicine, 2023 Heart failure results from various physiological and pathological stimuli that lead to cardiac hypertrophy. This pathological process is common in several cardiovascular diseases and ultimately leads to heart failure.
Masafumi Funamoto +3 more
doaj +2 more sources