Results 1 to 10 of about 35,141 (364)
The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis [PDF]
Frontiers in Oncology, 2015 Histone or non-histone protein acetylation plays important roles in all kinds of cellular events, including the normal and abnormal development of blood cells, through changing the epigenetic status of chromatin and regulating non-histone protein’s ...
Xiao-jian Sun, Stephen D Nimer, Lan Wang
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Histone Acetyltransferases and Stem Cell Identity. [PDF]
Cancers (Basel), 2021 Acetylation of histones is a key epigenetic modification involved in transcriptional regulation. The addition of acetyl groups to histone tails generally reduces histone-DNA interactions in the nucleosome leading to increased accessibility for transcription factors and core transcriptional machinery to bind their target sequences.
He R, Dantas A, Riabowol K.
europepmc +5 more sources
HAC1 and HAF1 Histone Acetyltransferases Have Different Roles in UV-B Responses in Arabidopsis [PDF]
Frontiers in Plant Science, 2017 Arabidopsis has 12 histone acetyltransferases grouped in four families: the GNAT/HAG, the MYST/HAM, the p300/CBP/HAC and the TAFII250/HAF families. We previously showed that ham1 and ham2 mutants accumulated higher damaged DNA after UV-B exposure than WT
Sebastián Rius, Paula Casati
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Regulating histone acetyltransferases and deacetylases [PDF]
EMBO reports, 2003 Histone acetyltransferases and histone deacetylases regulate the acetylation of histones and transcription factors, and in doing so have major roles in the control of cell fate. Many recent results have indicated that their function is strictly regulated in cells through the modulation of their levels, activity and availability for interaction with ...
Legube, G., Trouche, D.
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Histone acetyltransferases in plant development and plasticity. [PDF]
Curr Genomics, 2014 In eukaryotes, transcriptional regulation is determined by dynamic and reversible chromatin modifications, such as acetylation, methylation, phosphorylation, ubiquitination, glycosylation, that are essential for the processes of DNA replication, DNA-repair, recombination and gene transcription.
Boycheva I, Vassileva V, Iantcheva A.
europepmc +4 more sources
Histone Lysine and Genomic Targets of Histone Acetyltransferases in Mammals [PDF]
BioEssays, 2018 Histone acetylation has been recognized as an important post‐translational modification of core nucleosomal histones that changes access to the chromatin to allow gene transcription, DNA replication, and repair. Histone acetyltransferases were initially identified as co‐activators that link DNA‐binding transcription factors to the general ...
Anne K Voss, Tim Thomas
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The Role of Histone Acetyltransferases and Histone Deacetylases in Photoreceptor Differentiation and Degeneration. [PDF]
Int J Med Sci, 2020 Photoreceptors are critical components of the retina and play a role in the first step of the conversion of light to electrical signals. The differentiation and degeneration of photoreceptors are regulated by specific genes and proteins. With the development of epigenetic approaches, scientists have discovered that histone modifications, such as ...
Zhao M, Tao Y, Peng GH.
europepmc +5 more sources
The BRCA2 is a histone acetyltransferase [PDF]
Oncogene, 1998 Patients carrying mutations in BRCA1 or BRCA2 tumor suppressor genes have shown to have high risk in developing breast and ovarian cancers. Two potential functions of BRCA2 were proposed which includes role in the regulation of transcription and also in DNA repair.
J.-P. Zou +3 more
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Histone acetyltransferases: Rising ancient counterparts to protein kinases [PDF]
Biopolymers, 2013 Yuan H, Marmorstein R.
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Inhibition of histone acetyltransferase by glycosaminoglycans [PDF]
Journal of Cellular Biochemistry, 2008 AbstractHistone acetyltransferases (HATs) are a class of enzymes that participate in modulating chromatin structure and gene expression. Altered HAT activity has been implicated in a number of diseases, yet little is known about the regulation of HATs.
Edward Hsia +4 more
openaire +3 more sources