Epigenetic reprogramming in multiple myeloma—Challenges and opportunities
International Journal of Cancer, EarlyView.Abstract In cancer, mutational processes act in concert with epigenetic reprogramming to endow malignant cells with hallmark properties that underpin tumorigenesis. Compared with the relatively rigid and slow processes of genetic evolution, the plastic nature of chromatin enables cells to adapt to a changing environment more rapidly.
Subhasree Kumar +2 more
wiley +1 more source
The entropic lock and key of the histone code [PDF]
arXiv, 2013 The intricate pattern of chemical modifications on DNA and histones, the "histone code", is considered to be a key gene regulation factor. Multivalency is seen by many as an essential instrument to transmit the "encoded" information to the transcription machinery via multi-domain effector proteins and chromatin-associated complexes.
arxiv
The TAFII250 Subunit of TFIID Has Histone Acetyltransferase Activity [PDF]
, 1996 Craig A. Mizzen +11 more
openalex +1 more source
Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity. [PDF]
Circulation, 2022 Chakraborty R +14 more
europepmc +1 more source
GCN5 potentiates Hepatocellular Carcinoma by Promoting SRC3 gene expression [PDF]
, 2015 摘要 组蛋白乙酰化在转录调节过程中起着重要的作用，它可以使染色体处于一种活化的状态。在细胞中，维持组蛋白的乙酰化和去乙酰化之间的平衡是通过组蛋白乙酰转移酶（HATs）和组蛋白去乙酰化酶（HDACs）这二者间的平衡实现的。如果这二者间的平衡被打破了，那么基因的乙酰化水平就改变了，从而可能诱发癌症。虽然HDACs抑制剂可以有效的预防和治疗癌症，但是一些抑制剂会激活一些非靶基因从而使人出现抗药性。为了确保乙酰化和去乙酰化之间的完全平衡以及掌握在癌症中HATs在组蛋白乙酰化过程中特定的功能 ...
SIDRA MAJAZ
core
iMeta, EarlyView.Prenatal prednisone therapy (PPT)/prenatal prednisone exposure (PPE) induces long bone dysplasia, reduced peak bone mass (PBM), and increased osteoporosis susceptibility in female offspring. Maternal gut microbiota metabolite daidzein (DAI) mediates PPE‐induced osteoporosis susceptibility in female adult offspring.
Chi Ma +13 more
wiley +1 more source
Transcriptional Regulation of the MDR1 Gene by Histone Acetyltransferase and Deacetylase Is Mediated by NF-Y [PDF]
, 1998 Shengkan Jin, Kathleen W. Scotto
openalex +1 more source
Histone acetyltransferases CBP/p300 in tumorigenesis and CBP/p300 inhibitors as promising novel anticancer agents. [PDF]
Theranostics, 2022 Chen Q +5 more
europepmc +1 more source
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.Despite lacking DNMT3, EM‐seq revealed CpG methylation in the Colorado potato beetle. CUT&Tag analysis showed an association of H3K36me3 and H3K27ac with transcription, with H3K36me3 mirroring CpG methylation, demonstrating epigenetic flexibility.
Zoe M. Länger +6 more
wiley +1 more source
The DNA Single-Strand Break Repair Machinery Facilitates CAF-1-Mediated Histone Deposition at Oxidative DNA Strand Breaks [PDF]
arXiv, 2009 Oxidative DNA single strand breaks arise continuously in cells and defects in their repair have been implicated in neurological disease. While much progress has been made in understanding how chromosomal single strand breaks are repaired little is known about the changes chromatin structure that accompany this process.
arxiv