Histone acetyltransferases: challenges in targeting bi-substrate enzymes. [PDF]
Clin Epigenetics, 2016 Histone acetyltransferases (HATs) are epigenetic enzymes that install acetyl groups onto lysine residues of cellular proteins such as histones, transcription factors, nuclear receptors, and enzymes. HATs have been shown to play a role in diseases ranging
Wapenaar H, Dekker FJ.
europepmc +7 more sources
Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases. [PDF]
ACS Med Chem Lett, 2018 p300 and its paralog CBP can acetylate histones and other proteins and have been implicated in a number of diseases characterized by aberrant gene activation, such as cancer.
Michaelides MR +20 more
europepmc +2 more sources
Epigenetic Regulation of Matrix Metalloproteinase-1 and -3 Expression in Mycobacterium tuberculosis Infection [PDF]
Frontiers in Immunology, 2017 In pulmonary tuberculosis (TB), the inflammatory immune response against Mycobacterium tuberculosis (Mtb) is associated with tissue destruction and cavitation, which drives disease transmission, chronic lung disease, and mortality.
Rachel C. Moores +6 more
doaj +4 more sources
Histone acetyltransferases in plant development and plasticity. [PDF]
Curr Genomics, 2014 In eukaryotes, transcriptional regulation is determined by dynamic and reversible chromatin modifications, such as acetylation, methylation, phosphorylation, ubiquitination, glycosylation, that are essential for the processes of DNA replication, DNA ...
Boycheva I, Vassileva V, Iantcheva A.
europepmc +2 more sources
Dysregulation of histone acetyltransferases and deacetylases in cardiovascular diseases. [PDF]
Oxid Med Cell Longev, 2014 Cardiovascular disease (CVD) remains a leading cause of mortality worldwide despite advances in its prevention and management. A comprehensive understanding of factors which contribute to CVD is required in order to develop more effective treatment ...
Wang Y +6 more
europepmc +2 more sources
Histone acetylation and histone acetyltransferases show significant alterations in human abdominal aortic aneurysm. [PDF]
Clin Epigenetics, 2016 BackgroundEpigenetic modifications may play a relevant role in the pathogenesis of human abdominal aortic aneurysm (AAA). The aim of the study was therefore to investigate histone acetylation and expression of corresponding lysine [K] histone ...
Han Y +7 more
europepmc +2 more sources
Histone Lysine and Genomic Targets of Histone Acetyltransferases in Mammals [PDF]
BioEssays, 2018 Histone acetylation has been recognized as an important post‐translational modification of core nucleosomal histones that changes access to the chromatin to allow gene transcription, DNA replication, and repair.
A. Voss, T. Thomas
semanticscholar +4 more sources
The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy
Frontiers in Cell and Developmental Biology, 2020 Genetic mutations and abnormal gene regulation are key mechanisms underlying tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores, represent the basic units of chromatin. The fifth amino group (Nε) of histone lysine residues is a
Guo Li +4 more
doaj +2 more sources
Dysregulation of the p300/CBP histone acetyltransferases in human cancer. [PDF]
EpigenomicsXu L, Xuan H, Shi X.
europepmc +3 more sources
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2017 BACKGROUND AND OBJECTIVE: Curcumin, a natural polyphenolic compound derived from the rhizome of turmeric, has a cardiovascular protective effects. Histone acetyltransferase (HAT) is a consequential enzyme in processes of cardiac hypertrophy (cardiomegaly)
E Habibi, H Esmaeeli
doaj +1 more source