Results 191 to 200 of about 35,141 (364)

Reduction of DNA Topoisomerase Top2 Reprograms the Epigenetic Landscape and Extends Health and Life Span Across Species

Aging Cell, EarlyView.
This study demonstrates that reducing the enzyme topoisomerase Top2 or its mammalian homolog TOP2B promotes longevity across multiple species, including yeast, worms, and mice. At the cellular/molecular level, TOP2B reduction mitigates the major cellular aging hallmarks such as epigenetic alterations, cell senescence, lysosomal biogenesis, and ...
Man Zhu, Meng Ma, Lunan Luo, Feiyang Li, Jiashun Zheng, Yan Pan, Lu Yang, Ying Xiao, Ziyan Wang, Bo Xian, Yi Zheng, Hao Li, Jing Yang   +12 more
wiley   +1 more source

Histone H3 thiol reactivity and acetyltransferases in chicken erythrocyte nuclei.

, 1988
Shangfeng Chan, Liliana Attisano, Peter N. Lewis   +2 more
openalex   +1 more source

The Proprotein Convertase BLI‐4 Is Required for Axenic Dietary Restriction Mediated Longevity in Caenorhabditis elegans

Aging Cell, EarlyView.
In ADR‐induced longevity in C. elegans, neuronal BLI‐4 processes neuropeptides, which are then released with the assistance of UNC‐31 and GOLG‐2. ABSTRACT Dietary restriction (DR) is a well‐established method for extending lifespan across various species, including C. elegans.
Ping Wu, Lieselot Vandemeulebroucke, Huaihan Cai, Bart P. Braeckman   +3 more
wiley   +1 more source

Non-random acetylation of histone H4 by a cytoplasmic histone acetyltransferase as determined by novel methodology

, 1994
Richard Sobel, Richard G. Cook, C. David Allis   +2 more
openalex   +1 more source

Correction to “Alignment of Human KAT2A (GCN5) Histone Acetyltransferase and SARS‐CoV‐2 Orf8 Viral Proteins”

Chronic Diseases and Translational Medicine, EarlyView.
wiley   +1 more source

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

British Journal of Pharmacology, EarlyView.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

Changes in histone lysine acetylation, but not DNA methylation during facultative hibernation in Syrian hamster liver

Epigenetics Communications
Background Hibernation (torpor) is a strategy to survive extreme environmental conditions, associated with a significant decrease in metabolism and body temperature.
Marloes M. Oosterhof, Louis Coussement, Alienke van Pijkeren, Marcel Kwiatkowski, Martijn R. H. Zwinderman, Frank J. Dekker, Tim de Meyer, Vera A. Reitsema, Rainer Bischoff, Victor Guryev, Hjalmar R. Bouma, Rob H. Henning, Marianne G. Rots   +12 more
doaj   +1 more source

Purification and characterization of two porcine liver nuclear histone acetyltransferases.

, 1990
Liliana Attisano, Peter N. Lewis
openalex   +1 more source

E1A12S-mediated Activation of the Adenovirus Type 12 E2 Promoter Depends on the Histone Acetyltransferase Activity of p300/CBP [PDF]

, 2000
Peter Fax, Oliver Lehmkühler, Claudine Kühn, Helmut Esche, Dieter Brockmann   +4 more
openalex   +1 more source

CYP24A1 Binding to FUS Maintains Tumor Properties by Regulating the miR‐200c/ZEB1/EMT Axis

Cancer Science, Volume 116, Issue 4, Page 910-922, April 2025.
The active vitamin D‐degrading enzyme (CYP24A1) is a potential oncogene in ovarian and lung cancer. Mechanically, 87–297 amino acid motif of CYP24A1 bound specifically to FUS protein, consequentially reducing FUS affinity for miR‐200c. A reduction in miR‐200c levels resulted in a significant activation of its target gene ZEB1, thereby facilitating the ...
Ping Wang, Jiming Xu, Weijing You, Jie Li, Jing Yu, Fei Jiang, Zengli Zhang, Wentao Hu, Bingyan Li   +8 more
wiley   +1 more source