Results 201 to 210 of about 35,141 (364)

Novel Approach to Overcome Osimertinib Resistance Using Bromodomain and Extra‐Terminal Domain Inhibitors

Cancer Science, Volume 116, Issue 5, Page 1392-1404, May 2025.
Our study found that epigenetic changes, particularly histone modifications regulating FGF1, contribute to osimertinib resistance. Targeting these modifications with BET inhibitors may offer new therapeutic strategies. ABSTRACT Osimertinib, a third‐generation EGFR‐tyrosine kinase inhibitor, is the first‐line therapy for lung cancer harboring EGFR ...
Yosuke Miyashita, Ken Tajima, Kenta Izumi, Naohisa Matsumoto, Daisuke Hayakawa, Ikuko Takeda Nakamura, Isana Katayama, Adityo Wibowo, Hironari Matsuda, Wira Winardi, Bagus Radityo Amien, Yoichiro Mitsuishi, Fumiyuki Takahashi, Kohta Nakamura, Ken Uchibori, Noriko Yanagitani, Takuo Hayashi, Kazuya Takamochi, Kenji Suzuki, Ryohei Katayama, Kazuhisa Takahashi   +20 more
wiley   +1 more source

Repression of GCN5 Histone Acetyltransferase Activity via Bromodomain-Mediated Binding and Phosphorylation by the Ku–DNA-Dependent Protein Kinase Complex

, 1998
Nickolai A. Barlev, Vladimir Poltoratsky, Tom Owen‐Hughes, Carol Y. Ying, Lin Liu, Jerry L. Workman, Shelley L. Berger   +6 more
openalex   +1 more source

Transcriptional adaptor and histone acetyltransferase proteins in Arabidopsis and their interactions with CBF1, a transcriptional activator involved in cold-regulated gene expression [PDF]

, 2001
Eric J. Stockinger
openalex   +1 more source

Characterization of a cytoplasmic histone—coenzyme A acetyltransferase [PDF]

FEBS Letters, 1971
Oscar Sudilovsky, Angel Pestana, Henry C. Pitot   +2 more
openaire   +2 more sources

Lnc‐TPT1‐AS1/CBP/ATIC Axis Mediated Purine Metabolism Activation Promotes Breast Cancer Progression

Cancer Science, EarlyView.
Overexpression of TPT1‐AS1 could suppress the malignant phenotype and purine synthesis activation of breast cancer through competitive interaction with CBP, subsequently reducing the promoter H3K27ac signal and transcription of ATIC. Therefore, targeting the TPT1‐AS1/CBP/ATIC axis may provide a useful strategy for the treatment of patients with breast ...
Yiyun Zhang, Hanyu Zhang, Mingcui Li, Yanling Li, Zhuo‐Ran Wang, Weilun Cheng, Yansong Liu, Zhengbo Fang, Ang Zheng, Jingxuan Wang, Fei Ma   +10 more
wiley   +1 more source

The TFIIIC90 Subunit of TFIIIC Interacts with Multiple Components of the RNA Polymerase III Machinery and Contains a Histone-Specific Acetyltransferase Activity

, 1999
Yng-Ju Hsieh, Tapas K. Kundu, Zhengxin Wang, Robert Kovelman, Robert G. Roeder   +4 more
openalex   +1 more source

The HOX Homeodomain Proteins Block CBP Histone Acetyltransferase Activity [PDF]

, 2001
Wei-Fang Shen, Keerthi Krishnan, H. Jeffrey Lawrence, Corey Largman   +3 more
openalex   +1 more source

Testis‐Specific PDHA2 Is Required for Proper Meiotic Recombination and Chromosome Organisation During Spermatogenesis

Cell Proliferation, EarlyView.
PDHA2, a testis‐specific subunit of pyruvate dehydrogenase, is required for the conversion of pyruvate to acetyl‐CoA. Its absence results in decreased acetyl‐CoA and precursors for metabolites and energy during spermatogenesis. This results in decreased histone acetylation, defective chromosome structure and moderately reduced crossovers, ultimately ...
Guoqiang Wang, Kailun Fang, Yongliang Shang, Xu Zhou, Qiqi Shao, Si Li, Ping Wang, Charlie Degui Chen, Liangran Zhang, Shunxin Wang   +9 more
wiley   +1 more source

Acetylation of MyoD by p300 Requires More Than Its Histone Acetyltransferase Domain [PDF]

, 2001
Anna Polesskaya, Annick Harel‐Bellan
openalex   +1 more source

Membraneless Organelles and Phase Separation in Tumours: Mechanisms and Prospects

Cell Proliferation, EarlyView.
The Salient and Novel Findings: This article summarises the latest research advancements in phase separation within tumours, with a particular focus on the role and molecular mechanisms of liquid–liquid phase separation (LLPS) in tumour progression.
Hao Yang, Zhong Chu, Shuwen Han, Yuefen Pan   +3 more
wiley   +1 more source