Results 251 to 260 of about 223,415 (361)

Influenza A virus nucleoprotein is acetylated by histone acetyltransferases PCAF and GCN5. [PDF]

open access: yesJ Biol Chem, 2018
Hatakeyama D   +14 more
europepmc   +1 more source

The Pivotal Role of GR‐CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood

open access: yesAdvanced Science, Volume 13, Issue 6, 30 January 2026.
Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun   +9 more
wiley   +1 more source

Intrinsic ubiquitin E3 ligase activity of histone acetyltransferase Hbo1 for estrogen receptor α

open access: diamond, 2017
Masayoshi Iizuka   +4 more
openalex   +2 more sources

Metabolism‐Regulating Nanomedicines for Cancer Therapy

open access: yesAdvanced NanoBiomed Research, Volume 6, Issue 1, January 2026.
This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley   +1 more source

License to Replicate: Mechanisms of Licensing Eukaryotic Origins for DNA Replication

open access: yesBioEssays, Volume 48, Issue 1, January 2026.
Origin licensing constitutes the first step in initiating eukaryotic genome replication. Licensed origins are marked by an MCM double hexamer complex. This article reviews the molecular mechanisms of MCM double hexamer loading in yeast and higher eukaryotes, based on insights gained from biochemical reconstitution and structural analyses.
Victoria Frisbie, Franziska Bleichert
wiley   +1 more source

Pioneer Factor FOXA1 Boosts CHO Cell Productivity

open access: yesBiotechnology Journal, Volume 21, Issue 1, January 2026.
Graphical Abstract and Lay Summary FOXA1 binds directly to the EF1α and CMV promoters that are widely used to drive transgene expression. It stimulates transcription by recruiting cofactors that manipulate the epigenetic environment, including TET1 that demethylates DNA, p300 that acetylates histones and SWI/SNF that remodels nucleosomes.
Sienna P. Butterfield   +2 more
wiley   +1 more source

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