Results 271 to 280 of about 223,415 (361)

MOZ and HBO1 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98 -Rearranged Acute Myeloid Leukemia [PDF]

Charles G. Mullighan, Nicole L. Michmerhuizen, Emily Heikamp, Ilaria Iacobucci, Masayuki Umeda, Bright Arthur, Vibhor Mishra, Danika Di Giacomo, Ryan Hiltenbrand, Qingsong Gao, Sandi Radko-Juettner, Josi Lott, Cynthia Martucci, Varsha Subramanyam, Charlie Hatton, Pradyuamma Baviskar, Pablo Portola, Aurelie Claquin, Bappaditya Chandra, David W. Baggett, Ali Khalighifar, Hongling Huang, Peipei Zhou, Lingyun Long, Hao Shi, Yu Sun, Evangelia K. Papachristou, Chandra Chilamakuri, Francisca N. de Luna Vitorino, Joanna M. Gongora, Laura J. Janke, Alex Kentsis, Clive S. D’Santos, Benjamin A. Garcia, Richard W. Kriwacki, Hongbo Chi, Jeffery M. Klco, Scott A. Armstrong   +37 more
openalex   +1 more source

Developmental Impact of Maternal Immune Activation on the Fetal Immune System and Lung

European Journal of Immunology, Volume 56, Issue 1, January 2026.
Maternal immune activation triggers elevated cytokines (IL‐6 and IL‐17A), disrupting fetal immune system development. This not only alters hematopoietic stem cell balance but also leads to ILC2 hyperactivation in the lung, which could potentially affect susceptibility to allergic diseases in the offspring.
Walaa Jradi, Kira Duhm, Clarissa Prazeres da Costa   +2 more
wiley   +1 more source

Recognition of Unmodified Histone H3 by the First PHD Finger of Bromodomain-PHD Finger Protein 2 Provides Insights into the Regulation of Histone Acetyltransferases Monocytic Leukemic Zinc-finger Protein (MOZ) and MOZ-related factor (MORF)*

Journal of Biological Chemistry, 2011
S. Qin, Lei Jin, Jiahai Zhang, Lei Liu, P. Ji, Mian Wu, Jihui Wu, Yunyu Shi   +7 more
semanticscholar   +1 more source

Natural Dietary Compounds Targeting NF‐κB Signaling in Cancer: Implications for Nutrition‐Based Prevention and Therapy

Food Frontiers, Volume 7, Issue 1, January 2026.
ABSTRACT Dysregulation of the nuclear factor kappa B (NF‐κB) signaling pathway is closely associated with inflammation‐driven carcinogenesis, tumor progression and resistance to conventional therapies. Sustained NF‐κB activation enhances malignant cell survival, proliferation and immune evasion by promoting proinflammatory and antiapoptotic gene ...
Maria Sharif, Iqra Mutiullah, Kafila Kausar, Rashid Khan, Muhammad Irfan, Solomon Habtemariam, Khushbukhat Khan, Cristina Quispe, William C. Cho, Javad Sharifi‐Rad, Daniela Calina   +10 more
wiley   +1 more source

In Vitro Activity Assays for MYST Histone Acetyltransferases and Adaptation for High-Throughput Inhibitor Screening. [PDF]

Methods Enzymol, 2016
McCullough CE, Marmorstein R.
europepmc   +1 more source

Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases.

Molecules and Cells, 2001
N. Barlev, Lin Liu, N. Chehab, K. Mansfield, Kimberly G. Harris, T. Halazonetis, S. Berger   +6 more
semanticscholar   +1 more source

Highly effective combination of BRG1/BRM inhibitor with BET inhibitor or decitabine for high‐risk MECOM‐rearranged AML

HemaSphere, Volume 10, Issue 1, January 2026.
Abstract In AML with 3q26.2 rearrangements (r) the distal GATA2 hematopoietic enhancer becomes aberrantly relocated leading to activation of EVI1 expression. EVI1 is a transcriptional regulator that plays a role in proliferation and maintenance of a stem cell‐like phenotype in AML.
Warren Fiskus, Christopher P. Mill, Jessica Piel, Mike Collins, Murphy Hentemann, Branko Cuglievan, Christine E. Birdwell, Kaberi Das, John A. Davis, Hanxi Hou, Antrix Jain, Anna Malovannaya, Lauren B. Flores, Tapan M. Kadia, Naval Daver, Koji Sasaki, Koichi Takahashi, Danielle Hammond, Jian Wang, Sanam Loghavi, Xiaoping Su, Courtney D. DiNardo, Ruud Delwel, Kapil N. Bhalla   +23 more
wiley   +1 more source

Induction of NKG2D Ligands on Solid Tumors Requires Tumor-Specific CD8⁺ T Cells and Histone Acetyltransferases. [PDF]

Cancer Immunol Res, 2017
Hu J, Bernatchez C, Zhang L, Xia X, Kleinerman ES, Hung MC, Hwu P, Li S.   +7 more
europepmc   +1 more source

Inflammatory bowel disease and metabolic reprogramming: From pathological mechanisms to targeted interventions

Interdisciplinary Medicine, Volume 4, Issue 1, January 2026.
This review explores the role of metabolic reprogramming in inflammatory bowel disease (IBD) by focusing on immune and epithelial cell metabolism, microbial metabolites, and their impact on inflammation. It discusses emerging metabolic therapies and emphasizes the importance of personalized microbiota‐targeted approaches to improve clinical outcomes in
Zemin Tian, Yinde Huang, Ying Wang, Chenyu Zhao, Zhaokai Zhou, Hua Yang, Yuan Qiu   +6 more
wiley   +1 more source

Identification of the histone acetyltransferase gene family in the Platycodon grandiflorus genome [PDF]

Yang Xiang, Jingzhi Wan, Yong Ling Liao
openalex   +1 more source