Results 21 to 30 of about 35,141 (364)
Biological functions and therapeutic potential of acylation by histone acetyltransferases
Acta Materia Medica, 2023 Histone lysine acylation is a major class of histone post-translational modifications involved in essential biological activities, such as transcriptional regulation, DNA-damage repair, and cell-cycle progression.
Nan Li +6 more
doaj +1 more source
Autoacetylation of the Histone Acetyltransferase Rtt109 [PDF]
Journal of Biological Chemistry, 2011 Rtt109 is a yeast histone acetyltransferase (HAT) that associates with histone chaperones Asf1 and Vps75 to acetylate H3K56, H3K9, and H3K27 and is important in DNA replication and maintaining genomic integrity. Recently, mass spectrometry and structural studies of Rtt109 have shown that active site residue Lys-290 is acetylated.
Brittany N. Albaugh +3 more
openaire +3 more sources
Histone Acetylation and Modifiers in Renal Fibrosis
Frontiers in Pharmacology, 2022 Histones are the most abundant proteins bound to DNA in eukaryotic cells and frequently subjected to post-modifications such as acetylation, methylation, phosphorylation and ubiquitination.
Fengchen Shen +2 more
doaj +1 more source
Gcn5: The quintessential histone acetyltransferase
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2021 In this Special Issue, we bring together many of the original researchers involved in the initial studies to identify and characterize Gcn5, together with leaders from the field who have contributed to our understanding of this quintessential histone acetyltransferase.
openaire +5 more sources
Circadian Regulator CLOCK Is a Histone Acetyltransferase [PDF]
Cell, 2006 The molecular machinery that governs circadian rhythmicity comprises proteins whose interplay generates time-specific transcription of clock genes. The role of chromatin remodeling in a physiological setting such as the circadian clock is yet unclear.
Doi, Masao +2 more
openaire +5 more sources
Dynamic chromatin: concerted nucleosome remodelling and acetylation [PDF]
, 2005 The flexibility of chromatin that enables translation of environmental cues into changes in genome utilisation, relies on a battery of enzymes able to modulate chromatin structure in a highly targeted and regulated manner.
Becker, Peter +2 more
core +1 more source
The nature of the GRE influences the screening for GR-activity enhancing modulators [PDF]
, 2017 Glucocorticoid resistance (GCR), i.e. unresponsiveness to the beneficial anti-inflammatory activities of the glucocorticoid receptor (GR), poses a serious problem in the treatment of inflammatory diseases.
De Bosscher, Karolien +5 more
core +8 more sources
Temporal and spatial distribution of histone acetylation in mouse molar development. [PDF]
PeerJHistone acetylation is one of the most widely studied histone modification, regulating a variety of biological activities like organ development and tumorigenesis. However, the role of histone acetylation in tooth development is poorly understood.
Du W, Luo W, Zheng L, Zhou X, Du W.
europepmc +3 more sources
TGFβ impairs HNF1α functional activity in Epithelial-to-Mesenchymal Transition interfering with the recruitment of CBP/p300 acetyltransferases [PDF]
, 2019 The cytokine transforming growth factor β (TGFβ) plays a crucial role in the induction of both epithelial-to-mesenchymal transition (EMT) program and fibro-cirrhotic process in the liver, where it contributes also to organ inflammation following several ...
Amicone, Laura +8 more
core +1 more source
Stochastic epigenetic dynamics of gene switching [PDF]
Phys. Rev. E 102, 042408 (2020), 2020 Epigenetic modifications of histones crucially affect the eukaryotic gene activity, while the epigenetic histone state is largely determined by the binding of specific factors such as the transcription factors (TFs) to DNA. Here, the way how the TFs and the histone state are dynamically correlated is not obvious when the TF synthesis is regulated by ...
arxiv +1 more source