Results 31 to 40 of about 223,415 (361)
Regulating histone acetyltransferases and deacetylases [PDF]
EMBO reports, 2003 Histone acetyltransferases and histone deacetylases regulate the acetylation of histones and transcription factors, and in doing so have major roles in the control of cell fate. Many recent results have indicated that their function is strictly regulated in cells through the modulation of their levels, activity and availability for interaction with ...
Gaëlle, Legube, Didier, Trouche
openaire +2 more sources
Plant Responses to Abiotic Stress Regulated by Histone Deacetylases
Frontiers in Plant Science, 2017 In eukaryotic cells, histone acetylation and deacetylation play an important role in the regulation of gene expression. Histone acetylation levels are modulated by histone acetyltransferases and histone deacetylases (HDACs).
Ming Luo +5 more
doaj +1 more source
Epigenetic aberrations and cancer [PDF]
, 2006 The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms.
Brown, Mark A., Ducasse, Miryam
core +3 more sources
Activation of AMP-activated protein kinase by metformin induces protein acetylation in prostate and ovarian cancer cells [PDF]
, 2016 AMP-activated protein kinase (AMPK) is an energy sensor and master regulator of metabolism. AMPK functions as a fuel gauge monitoring systemic and cellular energy status.
Galdieri, Luciano +3 more
core +2 more sources
Temporal and spatial distribution of histone acetylation in mouse molar development [PDF]
PeerJHistone acetylation is one of the most widely studied histone modification, regulating a variety of biological activities like organ development and tumorigenesis. However, the role of histone acetylation in tooth development is poorly understood.
Wen Du +4 more
doaj +2 more sources
Roles and regulation of histone acetylation in hepatocellular carcinoma
Frontiers in Genetics, 2022 Hepatocellular Carcinoma (HCC) is the most frequent malignant tumor of the liver, but its prognosis is poor. Histone acetylation is an important epigenetic regulatory mode that modulates chromatin structure and transcriptional status to control gene ...
Jin-kun Xia +8 more
doaj +1 more source
Dynamic chromatin: concerted nucleosome remodelling and acetylation [PDF]
, 2005 The flexibility of chromatin that enables translation of environmental cues into changes in genome utilisation, relies on a battery of enzymes able to modulate chromatin structure in a highly targeted and regulated manner.
Becker, Peter +2 more
core +1 more source
ACL and HAT1 form a nuclear module to acetylate histone H4K5 and promote cell proliferation
Nature Communications, 2023 Acetyl-CoA utilized by histone acetyltransferases (HAT) for chromatin modification is mainly generated by ATP-citrate lyase (ACL) from glucose sources. How ACL locally establishes acetyl-CoA production for histone acetylation remains unclear.
Qiutao Xu +7 more
doaj +1 more source
Different adaptation strategies of two citrus scion/rootstock combinations in response to drought stress [PDF]
, 2017 Scion/rootstock interaction is important for plant development and for breeding programs. In this context, polyploid rootstocks presented several advantages, mainly in relation to biotic and abiotic stresses.
Bonatto, Diego +6 more
core +4 more sources
Nature Communications, 2021 Mutations in histone acetyltransferases (HATs) CREBBP and EP300 are generally thought to lead to decreased function or absence of protein product.
Manish Kumar +22 more
doaj +1 more source