Results 31 to 40 of about 35,141 (364)
Catalytic activation of histone acetyltransferase Rtt109 by a histone chaperone [PDF]
Proceedings of the National Academy of Sciences, 2010 Most histone acetyltransferases (HATs) function as multisubunit complexes in which accessory proteins regulate substrate specificity and catalytic efficiency. Rtt109 is a particularly interesting example of a HAT whose specificity and catalytic activity require association with either of two histone chaperones, Vps75 or Asf1.
Kolonko, Erin M. +8 more
openaire +4 more sources
Epigenetic Profiling Reveals a Developmental Decrease in Promoter Accessibility During Cortical Maturation in vivo [PDF]
, 2016 Axon regeneration in adult central nervous system (CNS) is limited in part by a developmental decline in the ability of injured neurons to re-express needed regeneration associated genes (RAGs).
Blackmore, Murray G. +3 more
core +2 more sources
Simulations Suggest Pharmacological Methods for Rescuing Long-Term Potentiation [PDF]
Journal of Theoretical Biology, 7 Nov 2014, pp. 243-250, 2014 Congenital cognitive dysfunctions are frequently due to deficits in molecular pathways that underlie synaptic plasticity. For example, Rubinstein-Taybi syndrome (RTS) is due to a mutation in cbp, encoding the histone acetyltransferase CREB-binding protein (CBP).
arxiv +1 more source
Characterization of yeast histone H3-specific type B histone acetyltransferases identifies an ADA2-independent Gcn5p activity [PDF]
, 2004 BACKGROUND: The acetylation of the core histone NH(2)-terminal tails is catalyzed by histone acetyltransferases. Histone acetyltransferases can be classified into two distinct groups (type A and B) on the basis of cellular localization and substrate ...
Parthun, Mark R, Sklenar, Amy R
core +3 more sources
Plant Responses to Abiotic Stress Regulated by Histone Deacetylases
Frontiers in Plant Science, 2017 In eukaryotic cells, histone acetylation and deacetylation play an important role in the regulation of gene expression. Histone acetylation levels are modulated by histone acetyltransferases and histone deacetylases (HDACs).
Ming Luo +5 more
doaj +1 more source
ACL and HAT1 form a nuclear module to acetylate histone H4K5 and promote cell proliferation
Nature Communications, 2023 Acetyl-CoA utilized by histone acetyltransferases (HAT) for chromatin modification is mainly generated by ATP-citrate lyase (ACL) from glucose sources. How ACL locally establishes acetyl-CoA production for histone acetylation remains unclear.
Qiutao Xu +7 more
doaj +1 more source
Roles and regulation of histone acetylation in hepatocellular carcinoma
Frontiers in Genetics, 2022 Hepatocellular Carcinoma (HCC) is the most frequent malignant tumor of the liver, but its prognosis is poor. Histone acetylation is an important epigenetic regulatory mode that modulates chromatin structure and transcriptional status to control gene ...
Jin-kun Xia +8 more
doaj +1 more source
Information Flow in Interaction Networks [PDF]
J. Comput. Biol., 14 (8): 1115-1143, 2007, 2011 Interaction networks, consisting of agents linked by their interactions, are ubiquitous across many disciplines of modern science. Many methods of analysis of interaction networks have been proposed, mainly concentrating on node degree distribution or aiming to discover clusters of agents that are very strongly connected between themselves.
arxiv +1 more source
Nature Communications, 2021 Mutations in histone acetyltransferases (HATs) CREBBP and EP300 are generally thought to lead to decreased function or absence of protein product.
Manish Kumar +22 more
doaj +1 more source
Peeling and Sliding in Nucleosome Repositioning [PDF]
Phys. Rev. Lett., 99, 058105, (2007), 2007 We investigate the mechanisms of histone sliding and detachment with a stochastic model that couples thermally-induced, passive histone sliding with active motor-driven histone unwrapping. Analysis of a passive loop or twist defect-mediated histone sliding mechanism shows that diffusional sliding is enhanced as larger portions of the DNA is peeled off ...
arxiv +1 more source