Results 41 to 50 of about 35,141 (364)
Regulation of skeletal muscle development and homeostasis by gene imprinting, histone acetylation and microRNA [PDF]
, 2015 Epigenetics is defined as heritable information other that the DNA sequence itself. The concept implies that the regulation of gene expression is highly complex and epigenetics can control from fine tuning to permanent gene activation/deactivation ...
ADAMO, Sergio +3 more
core +2 more sources
Molecular Basis of KAT2A Selecting Acyl-CoA Cofactors for Histone Modifications
Research, 2023 Emerging discoveries about undocumented acyltransferase activities of known histone acetyltransferases (HATs) advance our understandings in the regulation of histone modifications. However, the molecular basis of HATs selecting acyl coenzyme A (acyl-CoA)
Sha Li +7 more
doaj +1 more source
Histone acetyltransferases: challenges in targeting bi-substrate enzymes. [PDF]
Clin Epigenetics, 2016 Histone acetyltransferases (HATs) are epigenetic enzymes that install acetyl groups onto lysine residues of cellular proteins such as histones, transcription factors, nuclear receptors, and enzymes. HATs have been shown to play a role in diseases ranging
Wapenaar H, Dekker FJ.
europepmc +5 more sources
Structure of the NuA4 histone acetyltransferase complex
Proceedings of the National Academy of Sciences, 2022 Nucleosome acetyltransferase of H4 (NuA4), one of two major histone acetyltransferase complexes in Saccharomyces cerevisiae specifically acetylates histone H2A and H4, resulting in increased transcriptional activity.
Liting Ji +6 more
openaire +2 more sources
Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC
Hepatology, EarlyView., 2022 Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu +11 more
wiley +1 more source
Nucleosome sliding can influence the spreading of histone modifications [PDF]
, 2021 Nucleosomes are the fundamental building blocks of chromatin that not only help in the folding of chromatin but also in carrying epigenetic information. It is known that nucleosome sliding is responsible for dynamically organizing chromatin structure and the resulting gene regulation.
arxiv +1 more source
Plant responses to abiotic stress: the chromatin context of transcriptional regulation [PDF]
, 2017 The ability of plants to cope with abiotic environmental stresses such as drought, salinity, heat, cold or flooding relies on flexible mechanisms for re-programming gene expression. Over recent years it has become apparent that transcriptional regulation
Amtmann, Anna +2 more
core +1 more source
Hepatology, EarlyView., 2022 KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou +15 more
wiley +1 more source
A length-dynamic Tonks gas theory of histone isotherms [PDF]
Europhysics Letters, 62, 753-759, (2003), 2002 We find exact solutions to a new one-dimensional (1D) interacting particle theory and apply the results to the adsorption and wrapping of polymers (such as DNA) around protein particles (such as histones). Each adsorbed protein is represented by a Tonks gas particle.
arxiv +1 more source
Downregulating ANP32A rescues synapse and memory loss via chromatin remodeling in Alzheimer model
Molecular Neurodegeneration, 2017 Background The impairment of histone acetylation is causally linked to the cognitive decline in Alzheimer’s disease (AD). In addition to histone acetyltransferases (HATs) and histone deacetylases (HDACs), inhibitor of acetyltransferases (INHAT) can also ...
Gao-Shang Chai +9 more
doaj +1 more source