Epigenomes in Cardiovascular Disease. [PDF]
, 2018 If unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and ...
McKinsey TA +4 more
core +1 more source
Protein acetylation in archaea, bacteria, and eukaryotes [PDF]
, 2010 Proteins can be acetylated at the alpha-amino group of the N-terminal amino acid (methionine or the penultimate amino acid after methionine removal) or at the epsilon-amino group of internal lysines.
Lainio, Jarmo +1 more
core +1 more source
Epigenetic Modulation Using Small Molecules - Targeting Histone Acetyltransferases in Disease.
Current Medicinal Chemistry, 2017 Histone acetyltransferases (HATs) are epigenetic drivers that catalyze the acetyl transfer from acetyl-CoA to lysines of both histone and non-histone substrates and thereby induce transcription either by chromatin remodeling or direct transcription ...
A. Richters, A. Koehler
semanticscholar +1 more source
Downregulating ANP32A rescues synapse and memory loss via chromatin remodeling in Alzheimer model
Molecular Neurodegeneration, 2017 Background The impairment of histone acetylation is causally linked to the cognitive decline in Alzheimer’s disease (AD). In addition to histone acetyltransferases (HATs) and histone deacetylases (HDACs), inhibitor of acetyltransferases (INHAT) can also ...
Gao-Shang Chai +9 more
doaj +1 more source
A small molecule activator of p300/CBP histone acetyltransferase promotes survival and neurite growth in a cellular model of Parkinson’s disease [PDF]
, 2016 Parkinson’s disease (PD) is a progressive neurodegenerative disease characterised by motor and non-motor symptoms, resulting from the degeneration of nigrostriatal dopaminergic neurons and peripheral autonomic neurons.
Hegarty, Shane V. +5 more
core +1 more source
Inhibition of histone acetyltransferase by glycosaminoglycans [PDF]
Journal of Cellular Biochemistry, 2008 AbstractHistone acetyltransferases (HATs) are a class of enzymes that participate in modulating chromatin structure and gene expression. Altered HAT activity has been implicated in a number of diseases, yet little is known about the regulation of HATs.
Jo Ann, Buczek-Thomas +4 more
openaire +2 more sources
Identification of acetyltransferase genes (HAT1 and KAT8) regulating HBV replication by RNAi screening [PDF]
, 2015 Background: The initiation of hepatitis B virus (HBV) replication involves the formation of covalently closed circular DNA (cccDNA) and its transcription into pregenomic RNA (pgRNA) in hepatocyte nuclei.
Bernard A. M. Fang +10 more
core +3 more sources
Gcn5: The quintessential histone acetyltransferase
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2021 In this Special Issue, we bring together many of the original researchers involved in the initial studies to identify and characterize Gcn5, together with leaders from the field who have contributed to our understanding of this quintessential histone acetyltransferase.
openaire +4 more sources
The BRCA2 is a histone acetyltransferase [PDF]
Oncogene, 1998 Patients carrying mutations in BRCA1 or BRCA2 tumor suppressor genes have shown to have high risk in developing breast and ovarian cancers. Two potential functions of BRCA2 were proposed which includes role in the regulation of transcription and also in DNA repair.
H, Siddique +3 more
openaire +2 more sources
Molecular Basis of KAT2A Selecting Acyl-CoA Cofactors for Histone Modifications
Research, 2023 Emerging discoveries about undocumented acyltransferase activities of known histone acetyltransferases (HATs) advance our understandings in the regulation of histone modifications. However, the molecular basis of HATs selecting acyl coenzyme A (acyl-CoA)
Sha Li +7 more
doaj +1 more source