Results 181 to 190 of about 31,898 (266)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, Volume 13, Issue 35, 24 June 2026.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

The conserved histone chaperone Spt6 is strongly required for DNA replication and genome stability. [PDF]

Cell Rep, 2023
Miller CLW, Winston F.
europepmc   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, Volume 13, Issue 33, 15 June 2026.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Histone chaperone-based stratification combined with two-sample Mendelian randomization identifies ADORA2B and SAPCD2 as prognostic biomarkers in esophageal cancer. [PDF]

Front Oncol
Xia B, Liu Y, Zhao R, Deng K.
europepmc   +1 more source

Histone chaperone Nap1 dismantles an H2A/H2B dimer from a partially unwrapped nucleosome. [PDF]

Nucleic Acids Res, 2023
Nagae F, Takada S, Terakawa T.
europepmc   +1 more source

Sex differences in brain glucose metabolism and Alzheimer's disease risk and progression

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Sex differences are increasingly recognized as central to the biology of Alzheimer's disease (AD), yet the mechanisms through which they shape brain metabolism and disease vulnerability remain incompletely understood. Brain glucose hypometabolism is a core hallmark of AD and emerges decades before clinical decline, but accumulating evidence ...
Marjan Ramezan, Aphrodite Demetriou, Sara Nicole Burke, Ivan Nalvarte, Andrew C. Shin   +4 more
wiley   +1 more source

Sp100A isoform promotes localization of the histone chaperone HIRA to PML nuclear bodies. [PDF]

J Biol Chem
Della Fera AN, Arman W, Powers ME, Cachau RE, Warburton A, McBride AA.   +5 more
europepmc   +1 more source

Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma

eFood, Volume 7, Issue 3, June 2026.
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie, Wei Fang, Zean Song, Zhang Yu, Ying Zhu, Shaoping Liu   +5 more
wiley   +1 more source

Structural and functional insights into the nuclear role of Parkinson's disease-associated α-synuclein as a histone chaperone. [PDF]

Commun Biol
Jos S, Kambaru A, Prasad TK, Parthasarathi S, Kamariah N, Nath S, Padmanabhan B, Padavattan S.   +7 more
europepmc   +1 more source

Structure of IMPORTIN-4 bound to the H3-H4-ASF1 histone-histone chaperone complex. [PDF]

Proc Natl Acad Sci U S A, 2022
Bernardes NE, Fung HYJ, Li Y, Chen Z, Chook YM.   +4 more
europepmc   +1 more source