Results 181 to 190 of about 57,051 (248)
Targeting Tumor Stroma: Current Challenges and Future Directions
MedComm, Volume 7, Issue 5, May 2026.Figure 1. Mechanism of ECM reprogramming. Cancer‐associated fibroblasts (CAFs), cancer‐associated macrophages (CAMs), and other mesenchymal cells alter the ECM composition and increase its stiffness by depositing matrix components such as collagen and hyaluronic acid, and secreting cross‐linking agents like lysyl oxidase homolog 2 (LOXL2).
Siwei Wang +7 more
wiley +1 more source
Protein Science, Volume 35, Issue 5, May 2026.Abstract TAR DNA‐binding protein 43 (TDP‐43) plays a critical role in RNA metabolism and is incorporated into biomolecular condensates called stress granules. In amyotrophic lateral sclerosis (ALS) and several other neurodegenerative disorders, TDP‐43 undergoes aberrant phase transitions, forming insoluble amyloid aggregates, including fibrils composed
Emily J. Byrd +4 more
wiley +1 more source
Insights into Spt6: a histone chaperone that functions in transcription, DNA replication, and genome stability. [PDF]
Trends Genet, 2023 Miller CLW, Warner JL, Winston F.
europepmc +1 more source
Protein Science, Volume 35, Issue 5, May 2026.Abstract The histone fold is one of the most ancient and versatile structural motifs in protein biology, best known for its role in chromatin organization. A remarkable variation of this motif is the double histone fold (DHF), in which two histone folds are encoded within a single polypeptide chain and assemble intramolecularly into a histone‐like ...
Anna Ranaudo +3 more
wiley +1 more source
Journal of Diabetes, Volume 18, Issue 5, May 2026.This review highlights mitochondrial dysfunction as a central driver of pancreatic β cell failure in diabetes, caused by disrupted mitochondrial quality control (MQC), oxidative stress, and impaired organelle communication. Emerging therapies, such as DRAK2 inhibitors and metabolic reprogramming agents, show promise in restoring β cell function by ...
Ruihan Li +5 more
wiley +1 more source
Characterization of histone chaperone MCM2 as a key regulator in arsenic-induced depletion of H3.3 at genomic loci. [PDF]
Toxicol Appl Pharmacol, 2023 Wu P, Lin SJ, Chen D, Jin C.
europepmc +1 more source
Aging Cell, Volume 25, Issue 5, May 2026.We developed a LASSO‐based approach to uncover a three‐layered “fan‐in fan‐out” network architecture for complex traits like yeast aging, showing that peripheral genes influence lifespan indirectly through master regulators, which converge on core functional modules (e.g., stress response, autophagy).
Meng Ma +12 more
wiley +1 more source
Long‐Term Stress Adaptation as a Highly‐Conserved Key Factor in Yeast Aging
Aging Cell, Volume 25, Issue 5, May 2026.This study shows that long‐term, but not short‐term, stress exposure triggers molecular changes in yeast that mirror established hallmarks of aging, including altered proteostasis, epigenetic shifts, and reduced lifespan. These changes are reversible upon stress removal, and the genes involved are conserved across all domains of life. ABSTRACT Aging is
Yanzhuo Kong +7 more
wiley +1 more source
Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication. [PDF]
Commun Biol, 2023 Cho C +4 more
europepmc +1 more source
Histone Density and Dynamics Shape Mitotic Chromatid Architecture in Xenopus Egg Extracts
Genes to Cells, Volume 31, Issue 3, May 2026.Histone chaperones and chromatin remodelers modulate histone density and dynamics. The resulting local chromatin properties are integrated with DNA reconfiguration activities mediated by condensins and topoisomerase IIα to shape the global architecture of mitotic chromosomes.
Keishi Shintomi +3 more
wiley +1 more source