Lysine lactylation in diseases: beyond histone lactylation. [PDF]
Cell Death DisAbstract Lactylation, a recently identified post-translational modification, was initially characterized as lysine residue modification in histone subunits that regulates gene transcription via epigenetic mechanisms. Elevated intracellular lactate has been shown to drive histone lysine lactylation (Kla), establishing its association ...
Liu Y +6 more
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Metabolic reprogramming regulates histone lactylation during zebrafish caudal fin regeneration [PDF]
iScienceSummary: Tissue regeneration relies on precise molecular mechanisms controlling cell-fate transitions, with metabolism emerging as a key regulator. Lactate-derived histone lactylation has recently been identified as an epigenetic modification regulating ...
Jorge Borbinha +6 more
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Lactate-induced histone lactylation by p300 promotes osteoblast differentiation.
PLoS ONE, 2023 Lactate, which is synthesized as an end product by lactate dehydrogenase A (LDHA) from pyruvate during anaerobic glycolysis, has attracted attention for its energy metabolism and oxidant effects.
Erika Minami +7 more
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Role of Histone Lactylation in Neurological Disorders. [PDF]
Int J Mol SciLactate is not only the end product of glycolysis but also plays a key role in epigenetic regulation. Recently, lactate-derived histone lactylation has been identified as a novel epigenetic modification that can directly influence gene transcription.
Zhang YM, Yang F, Li Q, Zhang JN.
europepmc +3 more sources
Histone Lactylation in Diseases: Regulation by Traditional Chinese Medicine and Therapeutic Implications [PDF]
Drug Design, Development and TherapyYuyue Qiu, Xiaoni Shao College of Pharmacy and Food, Southwest Minzu University, Chengdu, Sichuan, 610225, People’s Republic of ChinaCorrespondence: Xiaoni Shao, College of Pharmacy and Food, Southwest Minzu University, #168 Dajian Street ...
Qiu Y, Shao X
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Histone Lactylation Antagonizes Senescence and Skeletal Muscle Aging by Modulating Aging‐Related Pathways [PDF]
Advanced ScienceEpigenetic alterations are among the prominent drivers of cellular senescence and/or aging, intricately orchestrating gene expression programs during these processes.
Fanju Meng +16 more
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Women with polycystic ovary syndrome exhibit impaired endometrial receptivity with excessive ERα and histone lactylation [PDF]
Nature CommunicationsPolycystic ovary syndrome (PCOS) is one of the most common reproductive disorders in women and severely impairs fertility. Extant clinical studies can only provide indirect and plausible evidence to support endometrial dysfunction as an ovary-independent
Hongying Shan +14 more
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Lactate and lysine lactylation of histone regulate transcription in cancer
HeliyonHistone lysine modifications were well-established epigenetic markers, with many types identified and extensively studied. The discovery of histone lysine lactylation had revealed a new form of epigenetic modification.
Yunhao Yang +5 more
doaj +3 more sources
From metabolic reprogramming to epigenetic modification: association network and targeted treatment strategy between histone lactylation and tumor progression [PDF]
Frontiers in ImmunologyMetabolic reprogramming and epigenetic modification have been widely observed in cancer research. Based on accumulating experimental evidence in recent years, beginning with metabolic reprogramming driven by carcinogenic signals, the accumulation of key ...
Yi Li +8 more
doaj +2 more sources
Lactate-mediated histone lactylation promotes melanoma angiogenesis via IL-33/ST2 axis [PDF]
Cell Death and DiseaseThe pathogenesis of cancer is complicated, with metabolic reprogramming and angiogenesis as the hallmark characteristics. Recent reports have unveiled that the glycolytic metabolite lactate could modify histone lactylation to epigenetically regulate gene
Mao Zhao +26 more
doaj +2 more sources