Results 141 to 150 of about 4,008 (211)

Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3‐Regulated HIF1A/HMOX1 Signaling Pathway

Advanced Science
Endometriosis (EMs) is a chronic gynecologic condition characterized by the growth of endometrial stromal and glandular tissue outside the uterine cavity of unknown etiology.
Zongwen Liang, Jinming Liu, Yanling Gou, Honglin Wang, Zhi Li, Yingying Cao, Huiyan Zhang, Ruru Bai, Zongfeng Zhang   +8 more
doaj   +1 more source

Histone lactylation couples cellular metabolism with developmental gene regulatory networks

Nature Communications
AbstractEmbryonic cells exhibit diverse metabolic states. Recent studies have demonstrated that metabolic reprogramming drives changes in cell identity by affecting gene expression. However, the connection between cellular metabolism and gene expression remains poorly understood.
Fjodor Merkuri, Megan Rothstein, Marcos Simoes-Costa   +2 more
openaire   +3 more sources

Lactylation as a cross-regulatory node in tumor metabolism and epigenetics: insights and therapeutic implications [PDF]

Lactylation serves as a pivotal cross-regulatory mechanism linking tumor metabolic reprogramming and epigenetic regulation. This review comprehensively summarizes the mechanisms of lactylation writers, erasers, and readers, highlighting their tumor ...
Jinhua Wu, Junna Jiao, Junna Jiao, Lulu Liu, Ruihan Wang, Ruohao Yang, Xiaoyu Shi, Zhuangwei Lv   +7 more
core   +1 more source

Histone lactylation-driven B7-H3 expression promotes tumor immune evasion

Theranostics
Rationale: Tumor cells possess sophisticated strategies to circumvent immune detection, including the modulation of endogenous immune checkpoints, particularly those within the B7 family. Elucidating the mechanisms that govern the induction of B7 family molecules is crucial for the advancement of immunotherapy.
Ma, Zhibo, Yang, Jincui, Jia, Wenlong, Li, Le, Li, Yixin, Hu, Junjie, Luo, Wei, Li, Ronghui, Ye, Dawei, Lan, Peixiang   +9 more
openaire   +2 more sources

Functional impacts of lactylation in Hypoxia‒primed mesenchymal stromal cells [PDF]

Hypoxic culture (1–5% O2) significantly enhances the biological activity and therapeutic potential of mesenchymal stromal cells (MSCs) by activating the HIF-1α signaling pathway.
Fanyi Zhao, Fanyi Zhao, Jie Liu, Jie Liu, Qixing Tang   +4 more
core   +1 more source

Lactate metabolism and lactylation in cardiovascular disease: novel mechanisms and therapeutic targets [PDF]

Cardiovascular disease (CVD) is responsible for approximately 30% of annual global mortality rates, yet existing treatments for this condition are considered less than ideal. Despite being previously overlooked, lactate, a byproduct of glycolysis, is now
Cheng Zhou, Cheng Zhou, Han Zhang, Han Zhang, Jiahong Xia, Jiahong Xia, Jiahong Xia, Jie Wu, Jie Wu, Jie Wu, Jiulu Zhao, Jiulu Zhao, Jizhang Yu, Jizhang Yu, Junjie Zong, Junjie Zong, Kexiao Zheng, Kexiao Zheng, Longyong Lai, Longyong Lai, Pinyan Huang, Pinyan Huang, Ran Li, Ran Li, Shuan Ran, Shuan Ran, Song Wang, Song Wang, Weicong Ye, Weicong Ye, Xi Zhang, Xi Zhang, Xiaohan Li, Xiaohan Li, Yanglin Hao, Yanglin Hao, Yuan Li, Yuan Li, Yuan Li, Zilong Luo, Zilong Luo   +40 more
core   +1 more source

Dux activates metabolism-lactylation-MET network during early iPSC reprogramming with Brg1 as the histone lactylation reader

Nucleic Acids Research
Abstract The process of induced pluripotent stem cells (iPSCs) reprogramming involves several crucial events, including the mesenchymal-epithelial transition (MET), activation of pluripotent genes, metabolic reprogramming, and epigenetic rewiring.
Xinglin Hu, Xingwei Huang, Yue Yang, Yuchen Sun, Yanhua Zhao, Zhijing Zhang, Dan Qiu, Yanshuang Wu, Guangming Wu, Lei Lei   +9 more
openaire   +2 more sources

Lactylation in tumor: mechanisms and therapeutic potentials [PDF]

Lactate, a central product of glucose metabolism, plays a vital role in energy supply and signal transduction, and it also participates in gene transcription regulation through lactylation.
Dandan Wang, Hao Rong, Jun Peng, Ke Ma
core   +1 more source

The effect of lactate dehydrogenase B and its mediated histone lactylation on chondrocyte ferroptosis during osteoarthritis

Journal of Orthopaedic Surgery and Research
Background Histone lactylation is a novel epigenetic regulator that is reported to participate in gene expression. Ferroptosis is an oxidative form of cell death and chondrocyte ferroptosis crucially impacts the development of osteoarthritis (OA).
Yang Zhang, Chen-Yu Zhao, Zheng Zhou, Cheng-Cun Li, Qiang Wang   +4 more
doaj   +1 more source

Lactate signalling in chemoresistance: from a potential threat to a therapeutic opportunity. [PDF]

Cancer cells are characterized by high glucose consumption, leading to increased lactate production. Once considered a waste product, lactate was recently shown to take part in the epigenetic regulation of gene expression, in promoting the unlimited ...
Rossi, Valentina <1992>
core   +1 more source