Results 151 to 160 of about 4,008 (211)

H3K14 lactylation exacerbates neuronal ferroptosis by inhibiting calcium efflux following intracerebral hemorrhagic stroke

Cell Death and Disease
Inhibiting neuronal ferroptosis is essential for mitigating neural damage and enhancing recovery in central nervous system (CNS) disorders, including intracerebral hemorrhagic stroke (ICH).
Tingting Sun, Jian-Nan Zhang, Ting Lan, Lei Shi, Liye Hu, Liyan Yan, Chao Wei, Lisha Hei, Weihua Wu, Zhaoli Luo, Meng Liu, Xingmei Ren, Yamei Wang, Yabin Lu, Peipei Wang, Chenguang Zhang, Liheng Bian, Xingquan Zhao, Fei Yang, Qian Li   +19 more
doaj   +1 more source

The lactylation-immunosuppression network in cancer: driving a metabolic-epigenetic axis

Frontiers in Immunology
The accumulation of lactate in the tumor microenvironment (TME), driven by the Warburg effect, is closely associated with immunosuppression. Lactate can contribute to this process through lysine lactylation, a novel post-translational modification.
Jinfeng Ye, Yunliang Lu, Wansu Huang, Shan Huang, Shan Huang, Zhe Zhang, Zhe Zhang, Xiaoying Zhou, Xiaoying Zhou, Xue Xiao, Tingting Huang   +10 more
doaj   +1 more source

The role of lactate-induced protein lactylation in gliomas: implications for preclinical research and the development of new treatments [PDF]

The most prevalent primary brain tumors in adults are gliomas. In addition to insufficient therapeutic alternatives, gliomas are fatal mostly due to the rapid proliferation and continuous infiltration of tumor cells into the surrounding healthy brain ...
Haichuan Wang, Xiaoying Liu, Yue Zhou
core   +1 more source

Lactate metabolism and histone lactylation in the central nervous system disorders: impacts and molecular mechanisms

Journal of Neuroinflammation
Brain takes up approximately 20% of the total body oxygen and glucose consumption due to its relatively high energy demand. Glucose is one of the major sources to generate ATP, the process of which can be realized via glycolysis, oxidative ...
Yao Wang, Ping Li, Yuan Xu, Linyu Feng, Yongkang Fang, Guini Song, Li Xu, Zhou Zhu, Wei Wang, Qi Mei, Minjie Xie   +10 more
doaj   +1 more source

H2BC9 lactylation modulates esophageal squamous cell carcinoma progression via the Wnt/β-catenin signaling pathway

Journal of Translational Medicine
Background Lactate, traditionally regarded as a metabolic waste product of glycolysis, has recently emerged as a critical signaling molecule and epigenetic modifier via protein lactylation.
Yuxiang Zhang, Ce Shi, Yun Zhou, Jing Zhu, Keke Xia, Lin Wang, Shuling Wang, Jie Mou, Lansheng Zhang, Dongsheng Pei   +9 more
doaj   +1 more source

Epigenetic Changes Associated With Obesity-related Metabolic Comorbidities [PDF]

Obesity arises from a complex interaction of genetic, hormonal, dietary, and behavioral factors that drive chronic energy imbalance, excessive fat accumulation, systemic inflammation, and insulin resistance, thus increasing the risk of metabolic diseases.

core   +1 more source

Histone lactylation modification and its role in cerebral ischemia-reperfusion injury (Review). [PDF]

Biomed Rep
Tao J, Xu J, Zhou L.
europepmc   +1 more source

ACSS2: Tumor-promoting lactyl-CoA synthetase that drives histone lactylation

hLife
Katherine L. Wang, Zhongsheng You
openaire   +2 more sources

Histone lactylation-derived TET2 enhanced Arg1-mediated MDSC immunosuppression. [PDF]

Front Immunol
Da W, Dai Y, Shen B, Zhang Y, Bao P, Zhu W, Wang D, Wang S, Ma J.   +8 more
europepmc   +1 more source

Histone Lactylation as an Epigenetic Regulator in Alzheimer's Disease Pathophysiology: A Narrative Review. [PDF]

J Inflamm Res
Tang J, Zhang Y, Wang Y, Fu Y, Qi J, Xiang A, Zhao R, Tan G, Deng H, Zhou X, Wu L.   +10 more
europepmc   +1 more source