Results 11 to 20 of about 4,008 (211)

Research progress and prospect of histone lactylation in digestive system tumors [PDF]

Zhongguo aizheng zazhi
Histone lactylation is a novel type of post-translational modification, where a lactate molecule covalently binds to the lysine residues of histones. This modification plays a key role in cellular metabolic reprogramming, particularly in digestive system
ZENG Dandan, LUO Wenfeng, YE Jiazhou, LIN Yan, LIANG Rong
doaj   +3 more sources

Non-histone lactylation: unveiling its functional significance [PDF]

Frontiers in Cell and Developmental Biology
Lactylation, a newly discovered protein posttranslational modification (PTM) in 2019, primarily occurs on lysine residues. Lactylation of histones was initially identified, and subsequent studies have increasingly demonstrated its widespread presence on non-histone proteins. Recently, high-throughput proteomics studies have identified a large number of
Pusong Shi, Yongjie Ma, Yongjie Ma, Yongjie Ma, Yongjie Ma, Yongjie Ma, Shaolu Zhang, Shaolu Zhang, Shaolu Zhang, Shaolu Zhang, Shaolu Zhang   +10 more
openaire   +5 more sources

Histone lactylation in macrophages is predictive for gene expression changes during ischemia induced-muscle regeneration [PDF]

Molecular Metabolism
Objectives: We have previously shown that lactate is an essential metabolite for macrophage polarisation during ischemia-induced muscle regeneration. Recent in vitro work has implicated histone lactylation, a direct derivative of lactate, in macrophage ...
Thibaut Desgeorges, Eva Galle, Jing Zhang, Ferdinand von Meyenn, Katrien De Bock   +4 more
doaj   +3 more sources

H4K79 and H4K91 histone lactylation, newly identified lactylation sites enriched in breast cancer. [PDF]

J Exp Clin Cancer Res
Abstract Metabolic reprogramming and epigenetic modification are two hallmarks of cancer. Protein lysine lactylation (Kla) is a novel type of glycolysis lactate-triggered posttranslational modification. However, the role of Kla in breast cancer (BC) remains largely unknown.
Liu J, Zhao L, Yan M, Jin S, Shang L, Wang J, Wang Q, Zhao S, Shen Z, Liu T, Wu H, Pang D.   +11 more
europepmc   +3 more sources

Glycolysis‐Histone Lactylation Crosstalk Drives TXNIP‐NLRP3‐Mediated PANoptosome Assembly and PANoptosis Activation Underlying Diabetic Retinopathy Pathogenesis [PDF]

MedComm
Diabetic retinopathy (DR), a major cause of vision loss in adults, involves aberrant metabolism and inflammation. This study investigated the interplay between glycolysis, histone lactylation, and PANoptosis in DR using human retinal pigment epithelial ...
Xiaoting Xi, Qianbo Chen, Jia Ma, Xuewei Wang, Yuxin Zhang, Qiuxia Xiong, Xiaolei Liu, Yuan Xia, Yan Li   +8 more
doaj   +2 more sources

Histone lactylation: A new epigenetic mark in the malaria parasite Plasmodium. [PDF]

PLoS Genet
Epigenetic processes play important roles in the biology of the malaria parasite Plasmodium falciparum. Here, we characterised a new epigenetic mark, histone lactylation, for the first time in Plasmodium: it was found in two human malaria parasites, P ...
Jabre I, Andoh NE, Naldoni J, Gregory W, Mbye H, Yoon CE, Cunnington AJ, Georgiadou A, Blagborough AM, Merrick CJ.   +9 more
europepmc   +3 more sources

Histone lactylation drives METTL3 upregulation-mediated RNA m6A modification of CCT2 to hinder CD8+ T cell survival in gastric cancer [PDF]

Cellular and Molecular Life Sciences
Background Histone lactylation represents a novel epigenetic modification that can modulate gene expression, further boosting tumor proliferation, metastasis, and immune suppression.
Zhenyuan Qian, Xufan Cai, Fang Wu, Zaiyuan Ye, Jianzhang Wu   +4 more
doaj   +2 more sources

Lipopolysaccharide-induced histone lactylation mediates m6A RNA modification causing mitochondrial dysfunction and pulmonary fibroblasts activation to exacerbate sepsis-associated pulmonary fibrosis [PDF]

Respiratory Research
Background Histone lactylation and N6-methyladenosine (m6A) alteration are epigenetic modifications that have a crucial function in controlling gene expression throughout fibroblast activation and organ fibrosis. However, their roles in sepsis-associated
Ri Tang, Shaojie Qin, Qiaoyi Xu, Wenyu Lin, Shuyi Zhang, Yawen Peng, Jinhua Feng, Shunpeng Xing, Yuan Gao, Shuya Mei, Zhengyu He   +10 more
doaj   +2 more sources

Lactate and lactylation: molecular insights into histone and non-histone lactylation in tumor progression, tumor immune microenvironment, and therapeutic strategies. [PDF]

Biomark Res
Abstract Investigating cancer metabolism is of paramount importance for understanding tumor biology and developing novel therapeutic strategies. Lactylation, a posttranslational modification facilitated by the glycolytic product lactate, plays a crucial role in regulating oncogenic signalling pathways.
Xiao S, Zhang S, Sun K, Huang Q, Li Q, Hu C.   +5 more
europepmc   +3 more sources

Mechanical Pressure, Histone Lactylation, And Salivary Gland Fibrosis

International Dental Journal
Aim or purpose: To investigate the link between mechanical pressure and histone lactylation in salivary gland fibrosis. Materials and methods: An animal model of salivary gland fibrosis was constructed by anatomically isolating and ligating the ...
Yubin Cao, Wang Guanru, Li Chunjie
doaj   +2 more sources