Results 191 to 200 of about 4,008 (211)

PFKM-Driven Lactate Overproduction Promotes Atrial Fibrillation via Triggering Cardiac Fibroblasts Histone Lactylation. [PDF]

Adv Sci (Weinh)
Fang N, Zhang N, Jiang X, Yan S, Wang Z, Gao Q, Xu M, Mu L, Li X, Chen J, Zhang S, Duan Y, Yun F, Li L, Zhang Y, Gong Y.   +15 more
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Histone lactylation exacerbates acute lung injury in septic mice by promoting ferroptosis in pulmonary microvascular endothelial cells. [PDF]

Burns Trauma
Fang P, Li S, Lu ZQ, Xia DL, Xu MM, Pan JJ, Fu L, Sun GY, You QH.   +8 more
europepmc   +1 more source

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Lactate, histone lactylation and cancer hallmarks

Expert Reviews in Molecular Medicine, 2023
Abstract Histone lactylation, an indicator of lactate level and glycolysis, has intrinsic connections with cell metabolism that represents a novel epigenetic code affecting the fate of cells including carcinogenesis. Through delineating the relationship between histone lactylation and cancer hallmarks, we propose histone lactylation as a novel ...
Xinyu Lv, Yingying Lv, Xiaofeng Dai
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LDHA promotes osteoblast differentiation through histone lactylation

Biochemical and Biophysical Research Communications, 2022
Osteoblast cells tend to metabolize glucose to lactate via aerobic glycolysis during osteogenic differentiation. However, the function of lactate in this process is still elusive. As a newly discovered protein posttranslational modification, lactate-derived histone lactylation has been found to play important roles in gene regulation and have profound ...
Feige, Nian, Yezhou, Qian, Fangyan, Xu, Mingfeng, Yang, Hongzhi, Wang, Zhufeng, Zhang   +5 more
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The crosstalking of lactate‐Histone lactylation and tumor

PROTEOMICS – Clinical Applications, 2023
ABSTRACTLactate was once considered to be a by‐product of energy metabolism, but its unique biological value was only gradually explored with the advent of the Warburg effect. As an end product of glycolysis, lactate can act as a substrate for energy metabolism, a signal transduction molecule, a regulator of the tumor microenvironment and immune cells,
Yao Rong, Fengyuan Dong, Guiqian Zhang, Mingzheng Tang, Xiashuang Zhao, Yan Zhang, Pengxian Tao, Hui Cai   +7 more
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Histone Lactylation: A New Role for Glucose Metabolism

Trends in Biochemical Sciences, 2020
Lactate is an end product of glucose metabolism, which serves metabolic and nonmetabolic functions. A new study by Zhang et al. establishes a novel function for lactate whereby it is utilized in a new histone modification, histone lysine lactylation, to regulate gene expression in macrophages.
Maria V, Liberti, Jason W, Locasale
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Histone Lactylation Boosts Reparative Gene Activation Post–Myocardial Infarction

Circulation Research, 2022
Background: Inflammation resolution and cardiac repair initiation after myocardial infarction (MI) require timely activation of reparative signals. Histone lactylation confers macrophage homeostatic gene expression signatures via transcriptional regulation.
Naixin Wang, Weiwei Wang, Xiaoqi Wang, Ge Mang, Jianfeng Chen, Xiangyu Yan, Zhonghua Tong, Qiannan Yang, Mengdi Wang, Liangqi Chen, Ping Sun, Yupeng Yang, Jingxuan Cui, Mian Yang, Yafei Zhang, Dongni Wang, Jian Wu, Maomao Zhang, Bo Yu   +18 more
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The TRIM33 Bromodomain Recognizes Histone Lysine Lactylation

ACS Chemical Biology
Histone lysine lactylation (Kla) regulates inflammatory gene expression in activated macrophages and mediates the polarization of inflammatory (M1) to reparative (M2) macrophages. However, the molecular mechanisms and key protein players involved in Kla-mediated transcriptional changes are unknown.
Raymundo Nuñez, Paul F. W. Sidlowski, Erica A. Steen, Sarah L. Wynia-Smith, Daniel J. Sprague, Robert F. Keyes, Brian C. Smith   +6 more
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Histone Lactylation Drives CD8 T Cell Metabolism and Function

2023
SummaryThe activation and functional differentiation of CD8 T cells are linked to metabolic pathways that result in the production of lactate. Lactylation is a lactate-derived histone post-translational modification (hPTM); however, the relevance of histone lactylation in the context of CD8 T cell activation and function is not known. Here, we show the
Deblina, Raychaudhuri, Pratishtha, Singh, Mercedes, Hennessey, Bidisha, Chakraborty, Aminah J, Tannir, Abel, Trujillo-Ocampo, Jin Seon, Im, Sangeeta, Goswami   +7 more
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The Oncogenic Regulation of Histone Lysine Lactylation

2021
L-lactate is generated during glycolysis, a metabolic pathway that is widely associated with many physiological and disease related processes. We recently reported the discovery of lysine L-lactylation [K(L-la)] as a novel protein posttranslational modification occurring on histone proteins that can contribute to gene transcription.
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